In Vitro Anti-Inflammatory Activity of Three Peptides Derived from the Byproduct of Rice Processing

Qu, Tingmin; He, Shuwen; Ni, Ce; Wu, Ying; Xu, Zhou; Chen, Mao-Long; Li, Honghui; Cheng, Yunhui; Wen, Li

doi:10.1007/s11130-022-00963-6

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…Wen et al ( 48 ) predicted four anti-inflammatory peptides using the computer prediction method of Net MHC II pan 4.0. However, almost all anti-inflammatory peptides screened by this method are peptides longer than 10, which may be because MCII has an open binding cleft and interacts mainly with long peptides of 13–25 lengths, which may be a defect of the model ( 49 ). The use of machine learning and docking of iNOS receptors in this work avoids the disadvantage of not being able to screen short peptides, which indicates that selecting appropriate targets will help screen more anti-inflammatory peptides.…”

Section: Resultsmentioning

confidence: 99%

Identification and virtual screening of novel anti-inflammatory peptides from broccoli fermented by Lactobacillus strains

Gao²,

Pan³

et al. 2023

Front. Nutr.

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Lactobacillus strains fermentation of broccoli as a good source of bioactive peptides has not been fully elucidated. In this work, the peptide composition of broccoli fermented by L. plantarum A3 and L. rhamnosus ATCC7469 was analyzed by peptidomics to study the protein digestion patterns after fermentation by different strains. Results showed that water-soluble proteins such as rubisco were abundant sources of peptides, which triggered the sustained release of peptides as the main target of hydrolysis. In addition, 17 novel anti-inflammatory peptides were identified by virtual screening. Among them, SIWYGPDRP had the strongest ability to inhibit the release of NO from inflammatory cells at a concentration of 25 μM with an inhibition rate of 52.32 ± 1.48%. RFR and KASFAFAGL had the strongest inhibitory effects on the secretion of TNF-α and IL-6, respectively. At a concentration of 25 μM, the corresponding inhibition rates were 74.61 ± 1.68% and 29.84 ± 0.63%, respectively. Molecular docking results showed that 17 peptides formed hydrogen bonds and hydrophobic interactions with inducible nitric oxide synthase (iNOS). This study is conducive to the high-value utilization of broccoli and reduction of the antibiotic use.

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Section: Resultsmentioning

confidence: 99%

Identification and virtual screening of novel anti-inflammatory peptides from broccoli fermented by Lactobacillus strains

Gao²,

Pan³

et al. 2023

Front. Nutr.

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“…Recent studies identified peptides from trypsin hydrolysates of rice protein with good anti-inflammatory activity in murine macrophages, such as peptide QRDFLLAGNKRNPQAY that was capable of reducing NO production and iNOS transcrition along with TNF-α, IL-6 and IL-1β transcription, or peptides IGVAMDYSASSKR, DNIQGITKPAIR and IAFKTNPNSMVSHIAGK that also showed inhibition of IL-1β, IL-6, and TNF-α gene expression but do not intervene in the regulation of NO production. 111,112…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies identified peptides from trypsin hydrolysates of rice protein with good antiinflammatory activity in murine macrophages, such as peptide QRDFLLAGNKRNPQAY that was capable of reducing NO production and iNOS transcrition along with TNF-α, IL-6 and IL-1β transcription, or peptides IGVAMDYSASSKR, DNIQGITKPAIR and IAFKTNPNSMVSHIAGK that also showed inhibition of IL-1β, IL-6, and TNF-α gene expression but do not intervene in the regulation of NO production. 111,112 Apart from enzymatic hydrolysis with trypsin, peptides PPYLSP, IIGGAL and FLPPVTSMG with strong anti-inflammatory activity have also been identified by hydrolyzing zein, a byproduct of corn starch, with an enzymatic mixture of Alcalase, neutral protease and thermolysin in combination with a subsequent simulated gastrointestinal digestion with gastric fluid and pancreatin. These three peptides exhibit their effect by decreasing TNF-α expression and inhibiting ICAM-1 by 36.5-28.6% along with VCAM-1 by 54-38.9%; and their action is believed to be due to their successful transport across Caco-2 cell monolayers without digestion by peptidases.…”

Section: Reviewmentioning

confidence: 99%

Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms

et al. 2022

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“…Papain and trypsin can specifically cleave alkaline amino acid side peptide bonds and enhance the anti-inflammatory activity of active peptides by exposing positively charged alkaline amino acids [ 73 , 74 ]. Udenigwe et al investigated the anti-inflammatory effects of flaxseed protein hydrolysates obtained using different proteases, and found that the proteolytic obtained using papain had the greatest ability to inhibit NO production in RAW264.7.…”

Section: Preparation Of Plant-derived Anti-inflammatory Peptidesmentioning

confidence: 99%

Anti-Inflammatory Function of Plant-Derived Bioactive Peptides: A Review

Liu

Chen

et al. 2022

Foods

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Inflammation is considered to be a crucial factor in the development of chronic diseases, eight of which were listed among the top ten causes of death worldwide in the World Health Organization’s World Health Statistics 2019. Moreover, traditional drugs for inflammation are often linked to undesirable side effects. As gentler alternatives to traditional anti-inflammatory drugs, plant-derived bioactive peptides have been shown to be effective interventions against various chronic diseases, including Alzheimer’s disease, cardiovascular disease and cancer. However, an adequate and systematic review of the structures and anti-inflammatory activities of plant-derived bioactive peptides has been lacking. This paper reviews the latest research on plant-derived anti-inflammatory peptides (PAPs), mainly including the specific regulatory mechanisms of PAPs; the structure–activity relationships of PAPs; and their enzymatic processing based on the structure–activity relationships. Moreover, current research problems for PAPs are discussed, such as the shallow exploration of mechanisms, enzymatic solution determination difficulty, low yield and unknown in vivo absorption and metabolism and proposed future research directions. This work aims to provide a reference for functional activity research, nutritional food development and the clinical applications of PAPs.

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In Vitro Anti-Inflammatory Activity of Three Peptides Derived from the Byproduct of Rice Processing

Cited by 16 publications

References 24 publications

Identification and virtual screening of novel anti-inflammatory peptides from broccoli fermented by Lactobacillus strains

Identification and virtual screening of novel anti-inflammatory peptides from broccoli fermented by Lactobacillus strains

Peptides and protein hydrolysates exhibiting anti-inflammatory activity: sources, structural features and modulation mechanisms

Anti-Inflammatory Function of Plant-Derived Bioactive Peptides: A Review

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