In vitro antibacterial activities of oral care products against ventilator-associated pneumonia pathogens

Şenol, Güneş; Kıraklı, Cenk; Halilçolar, Hüseyin

doi:10.1016/j.ajic.2006.10.016

Cited by 19 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The principal system components include a Y-connector that when placed on a suction cannister port provides the capability to attach 2 suctioning tubings, one for oral care and the other for the closed suction device; a universal handle that accommodates a variety of suctioning and cleansing devices; a covered Yankauer catheter to reduce the risk of contaminating the patient's environment; a suctioning dental brush with the antiseptic agent 0.05% cetylpyridinium chloride 17 designed for mechanical reduction of the quantity of dental plaque; a suction oral swab with 1.5% hydrogen peroxide 18 for cleansing the oral cavity and surrounding tissues; an applicator swab with moisturizers to promote mucosal integrity; and a suctioning catheter for removal of secretions that form in the oral cavity. The protocol for use of the system components included oropharyngeal suctioning every 6 hours, oral cleaning of the tissues and gums every 4 hours or as needed, and toothbrushing twice per day.…”

mentioning

confidence: 99%

Reducing Ventilator-Associated Pneumonia Through Advanced Oral-Dental Care: A 48-Month Study

Garcia¹,

Jendresky²,

Colbert³

et al. 2009

American Journal of Critical Care

View full text Add to dashboard Cite

Objective To determine the effect of implementing a comprehensive oral and dental care system and protocol on the rate of ventilator-associated pneumonia. Methods Patients more than 18 years old receiving mechanical ventilation for more than 48 hours in a medical intensive care unit at a university-affiliated medical center were studied in 2 consecutive 24-month periods. Patients in the group studied before the intervention (n = 779) had no oral assessments, no suctioning of the subglottic space, no toothbrushing, and suctioning of secretions in the oral cavity as needed. The group studied during the intervention (n = 759) included patients treated under a protocol whereby the oral cavity was assessed, deep suctioning was done every 6 hours, oral tissue cleansing was done every 4 hours or as needed, and toothbrushing was done twice daily. Results Compliance with protocol components exceeded 80%. The groups did not differ significantly in age, sex, or severity of illness. The rate of ventilator-associated pneumonia was 12.0 per 1000 ventilator days before the intervention and decreased to 8.0 per 1000 ventilator days during the intervention (P = .06). Duration of mechanical ventilation and length of stay in the intensive care unit differed significantly between groups, as did mortality. Conclusion Our findings suggest that use of advanced tools, a comprehensive oral care protocol, and staff compliance with the protocol can significantly reduce rates of ventilatorassociated pneumonia and associated costs. (American Journal of Critical Care.

show abstract

mentioning

confidence: 99%

Reducing Ventilator-Associated Pneumonia Through Advanced Oral-Dental Care: A 48-Month Study

Garcia¹,

Jendresky²,

Colbert³

et al. 2009

American Journal of Critical Care

View full text Add to dashboard Cite

show abstract

“…Test microorganism cultures were compared with the 0.5 McFarland turbidity standards for standardization prior to applying the disc diffusion method [9].…”

Section: Standardization Of Test Microorganismsmentioning

confidence: 99%

The antiproliferative and antimicrobial effects of cultivated <i>Anabaena circinalis</i> Rabenhorts ex Bornet and Flahault and <i>Nostoc entophytum</i> Bornet and Flahault

Yücer¹,

Beyatlı²,

Pabuçcu³

2018

Trop. J. Pharm Res

View full text Add to dashboard Cite

diffusion method in order to determine their antimicrobial effects. The anti-cancer activities of these two algae were tested against cancerous cell lines using BrdU cell proliferation ELISA method. The inhibition of these algae ethanol and butanol extracts were tested against Vero and HeLa carcinoma cells in concentrations of 100, 250 and 500 μg/mL. Results: Anabaena circinalis (AC) and Nostoc entophytum (NE) antimicrobial properties against the tes organisms. The buffer extract obtained from AC showed the highest level of antimicrobial activity against L. monocytogenes ATCC 7644 while the buffer extract from NE displayed the highest antimicrobial activity against E. coli O 157:H7. The anti-proliferative data indicate that NE has effective anti-cancer properties. Furthermore, the results showed that cyanobacteria species were superior to DMSO and control groups in terms of anti-cancer activity in tumor cells. NE exhibited significant (p < 0.05) anti-proliferative effects at all three concentrations (100, 250, 500 μg/mL), compared to DMSO while AC exhibited significant anti-proliferative activity only at 500 μg/mL concentration (p < 0.01). Conclusion: The results indicate that extracts possess antimicrobial and antiproliferative antivities. However, further studies are required to ascertain their clinical efficacy.

show abstract

“…A prevenção dessa contaminação é o principal desafio para o controle de infecção hospitalar. A mais importante via de aquisição da PAVM é pela colonização orofaríngea, pela microbiota endógena ou por patógenos exógenos adquiridos no ambiente da UTI, especialmente por meio das mãos dos profissionais de saúde, de equipamentos respiratórios contaminados ou da contaminação da água do hospital 20 .…”

Section: Etiopatogenia E Prevenção Da Pneumonia Nosocomialunclassified

A prevalência da pneumonia nosocomial e sua relação com a doença periodontal: revisão de literatura

Santi

Santos

2016

Rev. da Fac. de Odontologia, UPF

View full text Add to dashboard Cite

Objetivo: o presente trabalho pretende realizar uma revisão de literatura buscando estimar a prevalência da pneumonia nosocomial e verificar se há associação com a doença periodontal. Revisão da literatura: a pneumonia nosocomial é uma infecção do parênquima pulmonar causada por diferentes tipos de agentes etiológicos, resultando no desequilíbrio entre os mecanismos imunitários, especialmente em indivíduos internados em unidade de terapia intensiva. Sua ocorrência é reconhecida como um importante problema de saúde pública no Brasil e no mundo, com um aumento significativo de sua prevalência. A colonização do biofilme dental e a doença periodontal podem ter um papel muito importante como reservatório de microrganismos causadores dessa infecção, uma vez que a pneumonia nosocomial resulta da aspiração da flora da orofaringe para o trato respiratório inferior. Considerações finais: a literatura estudada sugere, seguramente, a relação da doença periodontal no estabelecimento da pneumonia nosocomial. Considerando que no Brasil essa infecção ocorre em um décimo dos pacientes internados na unidade de terapia intensiva, torna-se ainda mais importante o conhecimento da prevalência e de seus fatores associados para se pensar em estratégias eficazes de controle da doença.

show abstract

In vitro antibacterial activities of oral care products against ventilator-associated pneumonia pathogens

Cited by 19 publications

References 18 publications

Reducing Ventilator-Associated Pneumonia Through Advanced Oral-Dental Care: A 48-Month Study

Reducing Ventilator-Associated Pneumonia Through Advanced Oral-Dental Care: A 48-Month Study

The antiproliferative and antimicrobial effects of cultivated <i>Anabaena circinalis</i> Rabenhorts ex Bornet and Flahault and <i>Nostoc entophytum</i> Bornet and Flahault

A prevalência da pneumonia nosocomial e sua relação com a doença periodontal: revisão de literatura

Contact Info

Product

Resources

About