In-vitro antibacterial activity of the seed extract of three-member Artocarpus towards Methicillin-Resistant Staphylococcus aureus (MRSA)

Prastiyanto, Muhammad Evy; Azizah, Inas Hasna; Haqi, Hafizha Dara; Yulianto, Bagus; Agmala, Aulia Bella; Radipasari, Zhafira Dias; Astuti, Nita Ayu Dwi; Putri, Arifani Rahma

doi:10.29238/teknolabjournal.v9i2.237

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…The results of this study also showed better MIC value than some previous studies. Seed extracts of A. heterophyllus, A. champeden, and A. camansi against methicillin-resistant Staphylococcus aureus (MRSA) had MIC values of 15.62 mg/mL (Prastiyanto et al 2020a). A. heterophyllus seed extract had a MIC value of 125 mg/mL against MDR-Pseudomonas aeruginosa (Eve et al 2020).…”

Section: Determination Of Mic and Mbc Valuementioning

confidence: 99%

“…The MBC values of seed extracts of A. heterophyllus, A. champeden, and A. camansi against MRSA were 62.25 mg/ml, 31.25 mg/ml, and 250 mg/ml, respectively.) (Prastiyanto et al 2020a). Another study reported that A. heterophyllus leaf extracts did not have antibacterial activities against E. coli, as indicated by MIC and MBC values of 0 .…”

Section: Determination Of Mic and Mbc Valuementioning

confidence: 99%

“…Antibacterial agents derived from biological sources include mushrooms (Prastiyanto et al 2016;2020b), lactic acid bacteria (Lestari et al 2019), latex (Prastiyanto et al 2020c), fruits (Prastiyanto et al 2020d), and seeds (Prastiyanto et al 2020a). Many studies on antimicrobial agents report the importance of plants as alternative antimicrobial agents (Prastiyanto et al 2021a;Prastiyanto et al 2021b).…”

Section: Introductionmentioning

confidence: 99%

“…Many studies on antimicrobial agents report the importance of plants as alternative antimicrobial agents (Prastiyanto et al 2021a;Prastiyanto et al 2021b). It has been reported that seeds of three species of Artocarpus, namely jackfruit (A. heterophyllus), cempedak (A. champeden), and breadfruit (A. camansi) have the potential as antibacterial agents against Methicillin-Resistant Staphylococcus aureus (MRSA) (Prastiyanto et al 2020a). Aside from the three species of Artocarpus, other species of Artocarpus are found throughout Indonesia, namely A. lanceipolius, A. elasticus, and A. odoratissimus but no study has reported the antibacterial properties of the seeds of these species.…”

Section: Introductionmentioning

confidence: 99%

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Seeds extract of three Artocarpus species: Their in-vitro antibacterial activities against multidrug-resistant (MDR) Escherichia coli isolates from urinary tract infections (UTIs)

Prastiyanto

2021

Biodiversitas

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Abstract. Prastiyanto ME. 2021. Seeds extract of three Artocarpus species: Their in-vitro antibacterial activities against multidrug-resistant (MDR) Escherichia coli isolates from urinary tract infections (UTIs). Biodiversitas 22: 4362-4368. Multidrug-resistant (MDR)-E. coli is a major cause and has become a very serious problem in urinary tract infections (UTIs). As a result, it requires an antibacterial agent derived from biological materials. It has been reported that the seeds of three species of Artocarpus (A. heterophyllous, A. champeden, and A. camansi) have antibacterial properties against Methicillin-Resistant Staphylococcus aureus (MRSA). However, there are three other Artocarpus species in Indonesia, i.e., keledang (A. lanceipolius), tarra (A. elasticus), and terap (A. Odoratissimus) whose antibacterial property has not been investigated. To minimize the research gap, this study aims to determine the antibacterial activity of seed extracts of A. lanceipolius, A. elasticus, and A. odoratissimus against MDR-E. coli isolates of UTIs. Antibacterial activity was evaluated using the agar well diffusion assay. The microdilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. The results revealed that the seed extracts of A. lanceipolius, A. elasticus, and A. odoratissimus have the potential as antibacterial agents against MDR-E. coli isolate of UTIs. A. elasticus seed extract shows the widest zone of inhibition in the range of 7.0-13.3 mm and the smallest MIC and MBC values ??of 6.25-12.5 mg/mL and 12.5-25 mg/mL, respectively. In conclusion, A. lanceipolius, A. elasticus, and A. odoratissimus seed extracts have the potential to be developed as antibacterial agents against UTI-causing MDR-E. coli. Further in vivo research and determining the mode of action of antibacterial activity are needed.

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Section: Determination Of Mic and Mbc Valuementioning

confidence: 99%

Section: Determination Of Mic and Mbc Valuementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seeds extract of three Artocarpus species: Their in-vitro antibacterial activities against multidrug-resistant (MDR) Escherichia coli isolates from urinary tract infections (UTIs)

Prastiyanto

2021

Biodiversitas

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“…Thus, new antibacterial agents from natural biological sources are required. Biological antibacterial agents can be obtained from honey (Panjaitan et al 2018), mushrooms (Prastiyanto et al 2020b;, isolate bacteria from marine organisms (Asagabaldan et al 2019), bacteriocins (Lestari et al 2019), fruits (Prastiyanto et al 2020d;Wahyuni et al 2019), latex (Prastiyanto et al 2020c) and seeds (Ilvani et al 2019;Prastiyanto et al 2020a). Many studies in the medical field reported the importance of traditional medicinal plants as alternatives of antimicrobial agents (Akhtar and Mirza 2015;Aumeeruddy-elalfi et al 2015;Prastiyanto et al 2021).…”

Section: Introductionmentioning

confidence: 99%

In vitro antibacterial activities of crude extracts of nine plants on multidrug resistance bacterial isolates of wound infections

et al. 2021

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Abstract. Prastiyanto ME, Dewi NMBA, Pratiningtias TD, Pratiwi NMR, Windayani A, Wahyunengsih E, Astuti, Amir E, Wardoyo FA. 2021. In vitro antibacterial activities of crude extracts of nine plants on multidrug resistance bacterial isolates of wound infections. Biodiversitas 22: 2641-2647. Wound infections caused by bacteria is a become serious health problems, multidrug resistance bacteria (MDR) have increased this problem more severely, and therefore, antibacterial agents from natural biological sources are necessary to overcome these problems. This study examined the antibacterial activities of nine plants, i.e. garlic (Allium sativum), Solo garlic (Allium sativum), Java plum leaf (Syzygium cumini), Java plum fruit (Syzygium cumini), lime (Citrus aurantifolia), Kaffir lime (Citrus hystrix), Siamese weed (Chromolaena odorata), mangosteen (Garcinia mangostana) and bitter melon (Momordica charantia), against MDR bacteria isolated from wounds. The antibacterial activities were evaluated using agar well diffusion assay to determine the inhibition zones, and microdilution method to determine the value of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The best antibacterial activities were calculated as the most extensive inhibition zones with the smallest MIC and MBC values. Ethanol extracts from five plants (garlic, Solo garlic, Java plum (leaf), Kaffir lime and bitter melon) showed antibacterial activities against three MDR bacteria isolated from wounds. The bitter melon extract had the largest zones, 19.3 mm (methicillin-resistant Staphylococcus aureus [MRSA]), 10.6 mm (ESBL-producing Escherichia coli), and 13 mm (carbapenemase-resistant Pseudomonas aeruginosa [CRPA]) with the smallest MIC and MBC values against MRSA (3.12 and 25 mg/mL), ESBL- producing E. coli (12.25 and 50 mg/mL), and CRPA (6.25 and 25 mg/mL). This concludes that bitter melon has the potential to be developed as an antibacterial agent, particularly against MRSA strains, ESBL-producing E. coli, and CRPA that cause wound infections. Further in vivo research and the discovery of modes of action are needed to explain the antibacterial effects.

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Pemanfaatan Minyak Jelantah Dalam Pembuatan Sabun: Sebuah Enterpreunership Bagi Guru Kimia

Maharani

Fitria

Yusrin

et al. 2022

JIPMI

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Latar belakang: Limbah minyak jelantah dapat terjadi dari aktivitas rumah tangga maupun industri. Minyak jelantah adalah minyak goreng yang digunakan secara berulang sehingga bilangan peroksdanya tinggi dan menimbulkan bau tengik. Limbah minyak jelantah ini biasanya dibuang sembarangan di lingkungan, sehingga menimbulkan pencemaran air maupun tanah. Tujuan: meningkatkan pengetahuan guru kimia dalam menyampaikan materi berbasis lingkungan seperti pelatihan ketrampilan pemanfaatan limbah minyak jelantah untuk diolah menjadi sabun, dan peningkatan pengetahuan tentang manfaat sabun untuk kesehatan (sebagai antibakteri dengan penambahan antioksidan kulit kayu secang atau serbuk daun jambu). Permasalahan yang dihadapi para mitra adalah kurangnya pengetahuan guru dalam mengajarkan praktikum yang berbasis lingkungan. Metode: Mitra program ini adalah para guru SMA bidang studi kimia di Jawa Tengah yang merupakan alumni D3 Pendidikan Kimia IKIP Semarang Angkatan Tahun 1983 yang sedang reuni berjumlah 11 orang, tempat kegiatan di Hotel Mahima Semarang. Metode yang digunakan adalah ceramah dan pelatihan pembuatan sabun dari minyak jelantah. Hasil: Nilai rerata pre-test tentang materi kimia 4,72 dan post-test 8,18; sedangkan tentang manfaat sabun bagi kesehatan pre-test 7,00 dan post-test 9,09 sehingga terjadi peningkatan pengetahuan tentang materi kimia 91,60% dan tentang kesehatan 29,85%. Kesimpulan: Pelatihan pembuatan sabun dari limbah minyak jelantah dapat meningkatkan kompetensi guru kimia dalam mengajar materi yang berbasis lingkungan. Kegiatan ini disarankan untuk dilakukan secara berkelanjutan. Kata Kunci: minyak jelantah, peningkatan kompetensi, sabun, zat antibakteri __________________________________________________________________________________________ Background: Waste cooking oil can occur from household and industrial activities. Used cooking oil is cooking oil that is used repeatedly so that the peroxide value is high and causes a rancid odor. Waste cooking oil is usually disposed of carelessly in the environment, causing water and soil pollution. Objectives: to increase knowledge of chemistry teachers in delivering environmental-based materials such as skills training in the use of used cooking oil waste to be processed into soap, and increase knowledge about the benefits of soap for health as an antibacterial with the addition of antioxidants from secang bark or guava leaf powder. The problem faced by partners is the lack of knowledge of teachers in teaching environment-based practicum. Methods: Partners of the program are high school teachers in the field of chemistry in Central Java alumni of the D3 chemistry education IKIP Semarang Batch of 1983 who are having a reunion of 11 people, where the activity is at the Mahima Hotel Semarang. The method used lectures and training to make soap from used cooking oil. Results: The average value of the pre-test on chemistry is 4.72 and the post-test 8.18; while about the benefits of soap for health pre-test was 7.00 and post-test 9.09 so there is an increase in knowledge about chemistry material 91.60% and about health 29.85%. Conclusion: Training in making soap from used cooking oil waste from the environment can improve the competence of chemistry teachers in teaching environmentally-based materials. Keywords: waste cooking oil, competency improvement, soap, antibacterial agent

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In-vitro antibacterial activity of the seed extract of three-member Artocarpus towards Methicillin-Resistant Staphylococcus aureus (MRSA)

Cited by 5 publications

References 15 publications

Seeds extract of three Artocarpus species: Their in-vitro antibacterial activities against multidrug-resistant (MDR) Escherichia coli isolates from urinary tract infections (UTIs)

Seeds extract of three Artocarpus species: Their in-vitro antibacterial activities against multidrug-resistant (MDR) Escherichia coli isolates from urinary tract infections (UTIs)

In vitro antibacterial activities of crude extracts of nine plants on multidrug resistance bacterial isolates of wound infections

Pemanfaatan Minyak Jelantah Dalam Pembuatan Sabun: Sebuah Enterpreunership Bagi Guru Kimia

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