In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit

Balachandran, C.; Emi, Nobuhiko; Arun, Y.; Yamamoto, Yukiya; Ahilan, B.; Sangeetha, B.; Duraipandiyan, Veeramuthu; Inaguma, Yoko; Okamoto, Akinao; Ignacimuthu, S.; Al-Dhabi, N. A.; Perumal, Paramasivan T.

doi:10.1016/j.cbi.2015.09.023

Cited by 63 publications

(40 citation statements)

References 44 publications

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“…5‐Methoxyflavone showed a higher growth inhibitory activity than tagitinine C (its I 50 values on cress were 0.36–0.45 m mol L −1 ), the putative allelopathic substance of another invasive perennial weed, Tithonia diversifolia (Suzuki et al ). 5‐Methoxyflavone, 5,2′‐dimethoxyflavone and methyl caffeate have been reported regarding biological activity mostly concerning medicinal properties (Fotsis et al ; Liu & Nair ; Balachandran et al ), but this study's results indicated their plant growth inhibitory activity. This study, for the first time, indicates the plant growth inhibitory activity of 5‐methoxyflavone, 5,2′‐dimethoxyflavone and methyl caffeate and the presence of them as plant growth inhibitory substances in cogongrass rhizomes.…”

Section: Discussioncontrasting

confidence: 57%

Plant growth inhibitory activity and active substances with allelopathic potential of cogongrass (Imperata cylindrica) rhizome

Suzuki

Tominaga

Ohno

et al. 2018

Weed Biology and Management

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Cogongrass (Imperata cylindrica [L.] Raeusch.) is a perennial rhizomatous grass that belongs to the Poaceae and is widely distributed in tropical, subtropical and temperate regions over the world. The grass is strongly invasive and is suggested to have allelopathic potential. However, limited information is available on allelopathic substances in cogongrass rhizomes. Therefore, the allelopathic potential and substances in cogongrass rhizomes were investigated. The extracts of cogongrass rhizomes inhibited the root and shoot growth of barnyard grass, ryegrass, timothy, cress, lettuce and alfalfa. After bioassay-guided separations of the extracts, four growth inhibitory substances, 5-methoxyflavone, 5,2 0 -dimethoxyflavone, methyl caffeate and abscisic acid, were isolated. 5-Methoxyflavone, 5,2 0 -dimethoxyflavone and methyl caffeate significantly inhibited the root and shoot growth of cress at concentrations of ≥0.03-0.3 m mol L −1 and their concentrations required for 50% growth inhibition were 0.079-0.24, 0.23-1.1 and 0.59-0.88 m mol L −1 , respectively. The other isolated substance, abscisic acid, has been reported to have strong growth inhibitory activity. Its concentrations required for 50% growth inhibition on cress were 0.31-0.61 μ mol L −1 . The present study suggests that cogongrass rhizomes might have allelopathic potential and that those four substances might contribute to that potential.

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Section: Discussioncontrasting

confidence: 57%

Plant growth inhibitory activity and active substances with allelopathic potential of cogongrass (Imperata cylindrica) rhizome

Suzuki

Tominaga

Ohno

et al. 2018

Weed Biology and Management

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“…Interestingly, all compounds did not affect the viability of normal cells (monkey kidney VERO cell line) up to 30 μM. Methyl caffeate (2) has been reported as a promising anti-cancer agent by inducing apoptosis (Balachandran et al, 2015;Kim et al, 2019). In this study, compound 1 showed stronger cytotoxic effect than methyl caffeate.…”

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confidence: 59%

Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Kim

Nguyet

Anh

et al. 2019

Bangladesh J Pharmacol

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Cytotoxic phenolic constituents from the leaves of Ehretia asperula Sir, The genus Ehretia is mainly distributes in tropical areas of Asia, Africa, Northern America and exhibited valuable pharmacologial properties (Li et al., 2010; Shukla and Kaur, 2018). In Vietnam, Ehretia asperula Zoll. & Mort. has been used in traditional medicine for the treatment of ulcer, tumors, liver disease and inflammation (Nguyen et al., 2017). To date, there are few reports about the biological activities and chemical composition of this plant.

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“…The growth inhibitory effect of methyl caffeate may be a result of its quinone derivatives. Methyl caffeate has been isolated from several plants, such as Magnolia obavata [24], Polygonum amplexicaule [31] and Solanum torvum [7]. This compound has been reported to possess antihyperglycemic [13], antimicrobial [6], anticancer [8] and antioxidant activities [29].…”

Section: Discussionmentioning

confidence: 99%

Isolation and identification of a growth inhibitory substance from Heliotropium indicum L.

Chaipon

Suwitchayanon

Iwasaki

et al. 2018

Acta Biologica Hungarica

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Heliotropium indicum L. belongs to the family Boraginaceae. The plant has been used as a folk medicine because it contains substances of various biological activities. It is also identified as a common weed which grows wildly in crop fields in tropical and subtropical regions of the world. However, there is little information on the allelopathic effect in this plant. Therefore, this study was undertaken to investigate the growth inhibitory effect and to identify the growth inhibitory substances in H. indicum. An aqueous methanol extract of H. indicum inhibited shoot and root growth of barnyard grass, foxtail fescue, timothy, cress, lettuce and rapeseed at concentrations higher than 10 mg dry weight equivalent extract/mL. The concentrations required for 50% growth inhibition (I 50 ) of those test plants ranged from 3-282 mg dry weight equivalent extract/mL. The extract was then separated using a sequence of chromatographic fractionations and a growth inhibitory substance was isolated and identified by spectral analysis as methyl caffeate. Methyl caffeate inhibited the growth of lettuce and foxtail fescue at concentrations higher than 1.0 mM. The results suggest that methyl caffeate may contribute to the growth inhibitory effect of H. indicum and may play an important role in the allelopathic effect of H. indicum.

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In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit

Cited by 63 publications

References 44 publications

Plant growth inhibitory activity and active substances with allelopathic potential of cogongrass (Imperata cylindrica) rhizome

Plant growth inhibitory activity and active substances with allelopathic potential of cogongrass (Imperata cylindrica) rhizome

Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Isolation and identification of a growth inhibitory substance from Heliotropium indicum L.

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