In Vitro Antimicrobial Activity and Fungitoxicity of Syringic Acid, Caffeic Acid and 4-hydroxybenzoic Acid against Ganoderma Boninense

Chong, Khim Phin; Rossall, S.; Atong, Markus

doi:10.5539/jas.v1n2p15

Cited by 59 publications

(59 citation statements)

References 7 publications

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“…The parasiticidal effect more increased when adding (20, 25, 30 mg/ml) to reach a mean (38 9 10 4 , 44 9 10 4 , 53 9 10 4 promastigote/ml) respectively. These observations are in consistence with the study of Chong et al, reported that CA inhibits the radial growth of Ganoderma Boninense (Chong et al 2009). Another study by Ismaiel and Pierson investigated the effect of CA against Clostridium botulinum, they state that CA reduces the viability of Clostridium spores (Ismaiel and Pierson 1990).…”

Section: Discussionsupporting

confidence: 77%

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Herbal extract targets in Leishmania tropica

Mohammad

Shammary

Mageed³

et al. 2014

J Parasit Dis

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The present study aims to investigate the effect of some herbal extract such as phenolic compounds on the viability of Leishmania tropica promastigotes in vitro. Four tested chemical agents (caffeic acid (CA), ferulic acid (FA), syringic acid (SA) and 4-hydroxybenzoic acid (4-HBA)) were used in this study. The viability of Leishmania tropica promastigotes was investigated under five different concentrations (10, 15, 20, 25 and 30 mg/ml) of each agent after (72 h). CA was the most active agent on the promastigotes viability after 72 h exposure to 30 mg/ml concentration so that the parasiticidal effect reach (53 9 10 4 ) promastigote/ml. FA is the second agent in parasiticidal effect that parasiticidal effect reach to (50 9 10 4 promastigote/ml) at a concentration (30 mg/ml), 4-HBA is the third agent in parasiticidal effect that reach to (48 9 10 4 promastigote/ml) at a concentration (30 mg/ml), SA is the weakest agent in parasiticidal activity that reach to (44 9 10 4 promastigote/ml) at a concentration (30 mg/ml). It can be concluded that (CA, FA, SA and 4-HBA) possess acidal effect on the Leishmania tropica promastigotes in vitro.

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Section: Discussionsupporting

confidence: 77%

“…The solution of acetone (50 %) prepared by adding acetone: water (50:50 v/v). This solution was used as a solvent to the tested chemical agent (Chong et al 2009). …”

Section: Preparation Of the Tested Chemical Agentsmentioning

confidence: 99%

Herbal extract targets in Leishmania tropica

Mohammad

Shammary

Mageed³

et al. 2014

J Parasit Dis

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“…Hydroxybenzoic acids possess many other very important biological properties. pHydroxybenzoic acid exhibits antimicrobial, antifungal, antisickling and estrogenic activities (Chong et al 2009;Pugazhendhi et al 2005). o-Hydroxybenzoic acid (salicylic acid) has antiinflammatory, antiseptic, antifungal, antipyretic, analgesic and keratolitic properties (Lin and Nakatsui 1998).…”

Section: Introductionmentioning

confidence: 99%

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

Szopa

2013

Plant Growth Regul

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Phenolic acids, both benzoic and cinnamic acid derivatives, are plant metabolites with high therapeutic and cosmetic values. Methanolic extracts from the biomass of shoot and callus cultures of Aronia melanocarpa growing on seven variants of the Murashige and Skoog (MS) medium with different concentrations of plant growth regulators, BA and NAA, ranging from 0.1 to 3.0 mg l -1 , were examined for the production of free phenolic acids and cinnamic acid using the high-performance liquid chromatography (HPLC) method. The extracts from the shoot and callus cultures were confirmed to contain five of the twelve compounds tested for: caffeic, p-coumaric, p-hydroxybenzoic, syringic and vanillic acids. The shoot extracts contained additionally salicylic acid. Both the total amounts and the amounts of individual compounds in either the shoot or callus extracts were dependent on the concentration of cytokinin and auxin in the MS medium variants. The total amounts in the shoot and callus cultures were in the range from 93.52 to 217.00 mg 100 g -1 DW and from 47.11 to 83.83 mg 100 g -1 DW, respectively. The amounts of individual compounds showed wide variation, from 1.31 to 91.86 mg 100 g -1 DW in the shoot extracts, and from 2.58 to 40.16 mg 100 g -1 DW in the callus extracts. Salicylic acid (max. 91.86 mg 100 g -1 DW), p-coumaric acid (max. 62.39 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 50.66 mg 100 g -1 DW) dominated in the shoot extracts, while syringic acid (max. 40.16 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 23.59 mg 100 g -1 DW) were the main metabolites in the callus extracts. This is the first report on the quantitative analysis of benzoic and cinnamic acid derivatives in shoot and callus cultures of A. melanocarpa growing on MS-based media with different concentrations of selected plant growth regulators-BA and NAA. The obtained maximum amounts of some metabolites are of interest from a practical perspective.

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“…Hydroxybenzoic acids also possess many others very important biological properties. p-Hydroxybenzoic acid shows antimicrobial, antifungal, antisickling, and estrogenic activities (Pugazhendhi et al 2005;Chong et al 2009). o-Hydroxybenzoic acid (salicylic acid) has anti-inflammatory, antiseptic, antifungal, antipyretic, analgesic and keratolytic properties (Lin and Nakatsui 1998).…”

Section: Introductionmentioning

confidence: 99%

Accumulation of hydroxybenzoic acids and other biologically active phenolic acids in shoot and callus cultures of Aronia melanocarpa (Michx.) Elliott (black chokeberry)

Szopa

Muszyńska

2012

Plant Cell Tiss Organ Cult

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Phenolic acids are plant metabolites important in phytotherapy and also in cosmetology. In this study, proliferating shoot and callus cultures of Aronia melanocarpa were established and maintained on Linsmaier and Skoog (L-S) medium containing different levels of a-naphthaleneacetic acid (NAA) and 6-benzyladenine (BA), ranging from 0.1 to 3.0 mg l -1 . Methanolic extracts from the biomass of these cultures and from the fruits of soil-grown plants were used to determine the amounts of free phenolic acids and cinnamic acid using the high-performance liquid chromatography (HPLC) method. Out of a total of twelve analyzed compounds, all of the extracts contained four of them: caffeic acid, p-hydroxybenzoic acid, syringic acid, and vanillic acid. Moreover, shoot extracts also contained salicylic acid (o-hydroxybenzoic acid), while callus extracts contained p-coumaric acid. On the other hand, fruit extracts also contained both salicylic acid and p-coumaric acid. The total amount of the analyzed compounds in extracts from both shoot and callus cultures depended on the L-S medium used, and varied between 103.05 and 150.95 mg 100 g -1 dry weight (DW), and between 50.23 and 81.56 mg 100 g -1 DW, respectively. Both types of culture contained higher levels of phenolic acids than the fruit extracts (32.43 mg 100 g -1 DW). In shoot cultures, p-hydroxybenzoic acid and salicylic acid were the predominant metabolites (reaching 55.14 and 78.25 mg 100 g -1 DW, respectively), while in callus cultures, p-hydroxybenzoic acid (25.60 mg 100 g -1 DW) and syringic acid (41.20 mg 100 g -1 DW) were the main compounds. In fruit extracts, salicylic acid (15.60 mg 100 g -1 DW) and p-hydroxybenzoic acid (5.29 mg 100 g -1 DW) were predominant.

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In Vitro Antimicrobial Activity and Fungitoxicity of Syringic Acid, Caffeic Acid and 4-hydroxybenzoic Acid against Ganoderma Boninense

Cited by 59 publications

References 7 publications

Herbal extract targets in Leishmania tropica

Herbal extract targets in Leishmania tropica

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

Accumulation of hydroxybenzoic acids and other biologically active phenolic acids in shoot and callus cultures of Aronia melanocarpa (Michx.) Elliott (black chokeberry)

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