In vitro antioxidant activities of the polysaccharides from Tricholoma lobayense

Wang, Cui; Yan, Chen; Hu, Meili; Ding, Jingna; Xu, Cunji; Wang, Ruijun

doi:10.1016/j.ijbiomac.2012.01.005

Cited by 36 publications

(15 citation statements)

References 31 publications

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“…Polysaccharides from different mushrooms showed free radical scavenging activity [92], superoxide radical scavenging activity, reducing properties, lipid peroxidation inhibition, suppression of proliferation and oxidative stress, etc. [93] The activity not only depended on the fungal species but also on the chemical structure and arrangement of the active polysaccharide [75,[94][95][96]. Similarly, mixed carbohydrates, such as polysaccharide-peptide complexes, have also shown a potent antioxidant activity [97].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

2012

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Abstract:Polysaccharides from mushrooms have attracted a great deal of attention due to the many healthy benefits they have demonstrated, such as immunomodulation, anticancer activity, prevention and treatment of cardiovascular diseases, antiviral and antimicrobial effects, among others. Isolation and purification of polysaccharides commonly involve several steps, and different techniques are actually available in order to increase extraction yield and purity. Studies have demonstrated that the molecular structure and arrangement significantly influence the biological activity; therefore, there is a wide range of analytical techniques for the elucidation of chemical structures. Different polysaccharides have been isolated from mushrooms, most of them consisting of β-linked glucans, such as lentinan from Lentinus edodes, pleuran from Pleurotus species, schizophyllan from Schizophyllum commune, calocyban from Calocybe indica, or ganoderan and ganopoly from Ganoderma lucidum. This article reviews the main methods of polysaccharide isolation and structural characterization, as well as some of the most important polysaccharides isolated from mushrooms and the healthy benefits they provide.

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Section: Antioxidant Activitymentioning

confidence: 99%

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

2012

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“…Interestingly a number of hydroxyl rich polysaccharides, such as HA, have also antioxidant properties and are themselves inhibitors of oxygen free radical − O 2 * pointing the role of HA concentration [26,27]. The purpose of the present study was to investigate the ability of mannitol to reduce the degradation of HA by oxygen free radicals, using two different validated models of oxidative stress, firstly induced by xanthine (X) + xanthine oxidase (XO) (X/XO model), then by adding hydrogen peroxide (H 2 O 2 model).…”

Section: Introductionmentioning

confidence: 99%

Effect of Mannitol on Hyaluronic Acid Stability in Two in Vitro Models of Oxidative Stress

Rinaudo¹,

Lardy

Grange

et al. 2014

Polymers

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Abstract:In this paper, we propose the evaluation of the mannitol's ability to reduce hyaluronic acid (HA) degradation using two different models of oxidative stress. Firstly, a solution of hyaluronan and a solution of the same HA including mannitol in PBS buffer were submitted to an oxidative stress generated by the addition of xanthine + xanthine oxidase generating oxygen free radicals. Different enzyme concentrations were used and the HA properties were studied after 24 h of contact at ambient temperature. Decreases of the viscosity of the solution were assessed by rheometry (viscous and elastic module) and that of HA molecular weight was determined by steric exclusion chromatography. Rheologic behavior was assessed on identical HA solutions subjected to another model of oxidative stress imposed by addition of hydrogen peroxide. The influence of mannitol concentration on HA degradation was also demonstrated. Whatever the stress applied, it appears very clearly that mannitol protects hyaluronic acid from mediated oxygen free radicals degradation. These in vitro results suggest that mannitol could be a simple way to significantly increase the intra-articular residence time of the injected hyaluronic acid and therefore might improve viscosupplementation effectiveness.

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“…[5]. Our previous study of in vitro antioxidant activities revealed that TLH-3 had the strongest antioxidant activity amongst the T. lobayense polysaccharides, with an IC 50 value of 126 g/mL which is comparable to that of ascorbic acid [6]. TLH-3 has shown great potential for applications in various fields such as natural non-toxic anti-oxidants, foods, pharmaceuticals and cosmetics.…”

Section: Introductionmentioning

confidence: 91%

“…Superoxide radical scavenging was measured according to the method of Wang et al [6] with minor modifications. Briefly, 4.0 mL of Tris-HCl buffer (50 mM, PH 8.2), 4.2 mL of H 2 O and 1 mL of sample at different concentrations (50 g/mL-500 g/mL) were incubated at 25 • C for 20 min.…”

Section: Assay Of Superoxide Radical (O 2 − ) Scavengingmentioning

confidence: 99%

In vitro antioxidant activities of the polysaccharides from Tricholoma lobayense

Cited by 36 publications

References 31 publications

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

Effect of Mannitol on Hyaluronic Acid Stability in Two in Vitro Models of Oxidative Stress

A novel process for isolation and purification of the bioactive polysaccharide TLH-3′ from Tricholoma lobayense

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