In vitro antioxidant, antidiabetic, antiacetylcholine esterase, anticancer activities and RP-HPLC analysis of phenolics from the wild bottle gourd (Lagenaria siceraria (Molina) Standl.)

Attar, U. A.; Ghane, Savaliram G.

doi:10.1016/j.sajb.2019.08.004

Cited by 49 publications

(51 citation statements)

References 43 publications

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“…The leaves and fruits are rich sources of bio-active compounds such as cucurbitacins Ghane, 2018, 2019;Chanda et al, 2019) which have various health benefits such as antioxidant, antidiabetic, anti-tumor, anti-proliferrative and antimicrobial properties (Marzouk et al, 2012;Ma et al, 2014;Ku et al, 2017;Attar and Ghane, 2019). The contents of cucubitacins type E and I have been quantified in leaves (Mashilo et al, 2018;Chanda et al, 2019).…”

Section: Nutritional and Anti-nutritional Compositionsmentioning

confidence: 99%

Progress on Genetic Improvement and Analysis of Bottle Gourd [Lagenaria siceraria (Molina) Standl.] for Agronomic Traits, Nutrient Compositions, and Stress Tolerance: A Review

Mkhize

Mashilo

Shimelis

2021

Front. Sustain. Food Syst.

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Bottle gourd [Lagenaria siceraria (Molina) Standl.] is an important multi-purpose cucurbit crop grown for its leaf, fruit, and seed. It is widely cultivated and used for human consumption in sub-Saharan Africa (SSA) providing vital human nutrition and serving as food security crop. There is wide genetic variation among bottle gourd genetic resources in Africa for diverse qualitative and quantitative attributes for effective variety design, product development, and marketing. However, the crop is under- researched and -utilized, and improved varieties are yet to be developed and commercialized in the region. Therefore, the objective of this review is to provide the progress on bottle gourd genetic improvement and genetic analysis targeting agronomic and horticultural attributes, nutritional composition, biotic, and abiotic stress tolerance to guide current and future cultivar development, germplasm access, and conservation in SSA. The first section of the paper presents progress on breeding of bottle gourd for horticultural traits, agronomic performance, nutritional and anti-nutritional composition, and biotic and abiotic stress tolerance. This is followed by important highlights on key genetic resources of cultivated and wild bottle gourd for demand driven breeding. Lastly, the review summaries advances in bottle gourd genomics, genetic engineering and genome editing. Information presented in this paper should aid bottle gourd breeders and agronomists to develop and deploy new generation and promising varieties with farmer- and market -preferred attributes.

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Section: Nutritional and Anti-nutritional Compositionsmentioning

confidence: 99%

Progress on Genetic Improvement and Analysis of Bottle Gourd [Lagenaria siceraria (Molina) Standl.] for Agronomic Traits, Nutrient Compositions, and Stress Tolerance: A Review

Mkhize

Mashilo

Shimelis

2021

Front. Sustain. Food Syst.

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“…It is acknowledged that the chelating capacity of the metal will be involved in antioxidant activity, it might, at the same time, be affecting other functionalities that contribute to the activities of anti-oxidation [ 47 ]. Hence, possibly, the polysaccharides chelating impact on Fe 2+ might partly influence other activities of scavenging free radicals to safeguard the host organism against oxidative mutilation.…”

Section: Resultsmentioning

confidence: 99%

Characterization of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg Roots and their effects on antioxidant activity and H2O2-induced oxidative damage in RAW 264.7 cells

Huang

Khudoyberdiev

et al. 2021

BMC Chemistry

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This work presents an investigation on the composition and structure of polysaccharides from the roots of Tetrastigma hemsleyanum (THP) and its associated antioxidant activity. It further explores the protective effect of THP on RAW264.7 cells against cytotoxicity induced by H2O2. Ion chromatography (IC) revealed that THP contained glucose, arabinose, mannose, glucuronic acid, galactose and galacturonic acid, in different molar ratios. Furthermore, gel permeation chromatography-refractive index-multiangle laser light scattering (GPC-RI-MALS) was employed to deduce the relative molecular mass (Mw) of the polysaccharide, which was 177.1 ± 1.8 kDa. Fourier transform infrared spectroscopy (FT-IR) and Congo red binding assay highlighted that the THP had a steady α-triple helix conformation. Similarly, assays of antioxidant activity disclosed that THP had reasonable concentration-dependent hydroxyl radical and superoxide radical scavenging activities, peroxidation inhibition ability and ferrous ion chelating potency, in addition to a significant 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity. Moreover, THP could protect RAW264.7 cells against H2O2-induced cytotoxicity by decreasing intracellular ROS levels, reducing catalase (CAT) and superoxide dismutase (SOD) activities, increasing lactate dehydrogenase (LDH) activity and increment in malondialdehyde (MDA) level. Data retrieved from the in vitro models explicitly established the antioxidant capability of polysaccharides from T. hemsleyanum root extracts.

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“…Many biologically active compounds have been identified in Cucurbitaceae family including phenolics, steroidal glucosides, alkaloids [9], conjugated linolenic acid isomers [10], lysophosphatidylcholines [11], organosulfur compounds, and cucurbitane-type triterpenoids [12,13]. Certain common diseases such as diabetic mellitus, hypoglycemia, heart disease, HIV (human immunodeficiency virus), cancer, and microbial infections have been investigated to treat with phytochemical fractions and compounds isolated from gourd family [14,15]. e aim of presented study was to investigate the antioxidant, antibacterial, and anticancer activities of BG fruit extracts at three different cultivation stages for taking the maximum advantage of BG in functional food and phytomedicine practice.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages

Naqvi

Ali

Sherazi

et al. 2020

Journal of Chemistry

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In this study, we are presenting the effect of three ripening stages of air-dried bitter gourd fruit extracts on phenolic acid composition, antioxidant, antibacterial, and anticancer activities. The results showed mature bitter gourd fruit extract in 100% methanol showing 78% DPPHº scavenging activity. Immature dried fruit extract in 80% and 100% methanol showed promising antibacterial activities, i.e., >18.5 ± 0.21 mm zone-of-inhibition against Staphylococcus aureus, while mature dried fruit extract in 80% methanol showed 18.4 ± 0.17 mm zone-of-inhibition against Escherichia coli. Anticancer activity results of 100% methanol extracts of ripened fruit possess showed 6.72 ± 1.81 and 3.55 ± 0.51 mg/mL IC50 values with HeLa and MDBK cancer cell lines, respectively. The overall results indicate that the immature and ripen fruits of BG could be extracted in pure methanol as an antibacterial and anticancer phytomedicine.

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In vitro antioxidant, antidiabetic, antiacetylcholine esterase, anticancer activities and RP-HPLC analysis of phenolics from the wild bottle gourd (Lagenaria siceraria (Molina) Standl.)

Cited by 49 publications

References 43 publications

Progress on Genetic Improvement and Analysis of Bottle Gourd [Lagenaria siceraria (Molina) Standl.] for Agronomic Traits, Nutrient Compositions, and Stress Tolerance: A Review

Progress on Genetic Improvement and Analysis of Bottle Gourd [Lagenaria siceraria (Molina) Standl.] for Agronomic Traits, Nutrient Compositions, and Stress Tolerance: A Review

Characterization of polysaccharides from Tetrastigma hemsleyanum Diels et Gilg Roots and their effects on antioxidant activity and H2O2-induced oxidative damage in RAW 264.7 cells

Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages

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