In vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract of Quercus brantii L. acorn and subsequent fractions

Moradi, Mohammad-Taghi; Karimi, Ali; Alidadi, Somayeh

doi:10.1016/s1875-5364(16)30016-4

Cited by 24 publications

(18 citation statements)

References 27 publications

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“…In addition, Quercus species have been reported to have antibacterial (Güllüce and others ; Basri and Fan, ; Jamil and others ), antiviral (Muliawan and others ; Karimi and others ), as well as gastroprotective effects (Gharzouli and others ; Sánchez‐Burgos and others ). More recently, acorns have also been highlighted for their antiproliferative and apoptosis‐inducing activities (Moradi and others ), and also for their neuroprotective activity (Custódio and others ).…”

Section: Acorns As An Alternative Foodmentioning

confidence: 99%

A New Age forQuercusspp. Fruits: Review on Nutritional and Phytochemical Composition and Related Biological Activities of Acorns

Vinha

Barreira

Costa

et al. 2016

Comp Rev Food Sci Food Safe

107

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Abstract:The current global food system must adapt to the expected growth of world population (about 9 billion individuals by 2050). This adaptation will probably include an increased consumption of edible wild foods, due to their richness in micronutrients and bioactive compounds, besides providing a cost-effective and sustainable way of improving caloric food security. A striking example of such natural matrices is the Quercus genus, which has the additional advantage of being widespread throughout the Northern Hemisphere. In a traditional sense, Quercus fruits (acorns) were mainly used in animal feeding, despite their potentially important role on the rural economy. But this preconception is changing. In fact, their nutritional value, high contents in phytochemical compounds, biological activity (such as antioxidant, anticarcinogenic, and cardioprotective properties) and use in the treatment of specific diseases (such as atherosclerosis, diabetes, or Alzheimer's disease) have raised the interest in integrating acorns into the human diet. Accordingly, this comprehensive overview was designed to provide an evidence-based review of the literature, with the objective to achieve useful conclusions regarding the nutritional properties, methodologies of extraction, identification, and characterization of a wide variety of bioactive compounds and scientifically validated bioactivities in Quercus species worldwide. The industrial by-products from acorn oil extraction or flour production are also included. Data regarding the analytical techniques, individual compounds, and their bioactivities, are organized in tables. The reported data are discussed and directions for further investigations are suggested, highlighting the use of acorns in food, nutraceutical, and pharmaceutical applications.

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Section: Acorns As An Alternative Foodmentioning

confidence: 99%

A New Age forQuercusspp. Fruits: Review on Nutritional and Phytochemical Composition and Related Biological Activities of Acorns

Vinha

Barreira

Costa

et al. 2016

Comp Rev Food Sci Food Safe

107

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show abstract

“…Today the medications and nutritional supplements factories pay a special attention to natural resources, and tend to use a large amount of local flora into the production. Besides that, efforts have been gradually more to use herbal drugs as substitute medicine [9][10][11][12][13][14][15]. In this aspect, different recent studies have sought after to assess conventional uses and in vitro detection to identify and isolate their active compound for developing drugs from herbal origion [16,17].…”

Section: Discussionmentioning

confidence: 99%

Biochemical, Enzymatic, and Immunological Study on Antimutagenic Achillea millefolium Methanolic Extract in vivo

Hussein¹,

Al-Ezzy²,

Abdallah³

2019

JPP

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Traditionally medicinal plants are used for its potential chemotherapeutic action and for safety upon the continued use of these plants. Achillea millefolium (AM) is an ancient herb which is used to treat wounds, headaches, disorder in gastrointestinal and hepatobiliary, pain, and inflammation. This study was aimed to investigate the biochemical parameter of antimutagenic methanolic extract for AM in vivo. Plant extract together with MTX decreased the damage caused by the drug on the concentrations of total cholesterol and triglycerides (160.3±2.26 and 108.7±2.71), significant increase in total protein concentration (8.51±0.17, 9.46±0.19 and 10.8±2.71 g\dL) for 100 and 200 mg\kg was observed. Also plant extracts counteract the damage caused by drug through the reduction for both creatinin and albumin concentrations to 1.57±0.03 mg\dL and 4.56±0.09 g\dL, respectively. On enzymatic level, the results of interactions indicated the ability of plant to modulating harmful effects of the drug (57.1±1.3, 130±3.1 and 111.1±2.1 U\L) for GOT, GPT and ALP, respectively. On the other hand, the plant possesses the ability to enhance the concentrations of all immunoglobulin (IgM, IgA and IgG) in the two doses tested. Therefore, the results of this study indicate the antimutagenic potential of AM extract and encouraging its consumption with MTX as one of the promising therapies.

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“…Therefore, in order to identify the probable sources of herbal medicines several plants are being gathered and examined [6][7][8][9][10][11]. Besides, different screening experiments have been performed on these plants to isolate the agents with antiviral activity [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

In vitro anti influenza virus activity, antioxidant potential and total phenolic content of twelve Iranian medicinal plants

Moradi¹,

Karimi²,

Lorigooini³

et al. 2017

mpj

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The emergence of medicine resistance strains of influenza A viruses to the chemical drogs lead to the development of alternative herbal compounds that inhibit the virus replication. Therefore, the aim of this research was to investigate in vitro anti-influenza A viruses activity, antioxidant potential, total phenolic, and flavonoid content of a total of 12 hydro alcoholic crude extracts obtained from 8 kinds of medicinal plants. Antiinfluenza A viruses activity of the extracts was investigated by the using of MDCK cell line and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) method. Both 50% inhibitory concentration (IC 50 ) and 50% cytotoxicity concentration (CC 50 ) of the extracts were identified using regression analysis. The antioxidant activity, total phenol, and flavonoid content of the extracts were determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, Folin-Ciocalteu method, and aluminum chloride colorimetric method, respectively. The results demonstrated that there was high activity against influenza virus for Peganum harmala L., Equisetum arvense L., and Punica granatum L, extracts with IC 50 value of 9.1 (CI95%:7.3-11.3), 6.45 (CI95%: 4.5-9.23), and 104.5 (CI95%: 82.8-131.8), respectively. DPPH radical scavenging activity showed that both Equisetum arvense L. and Punica granatum L. demonstrated the highest antioxidant activity with IC 50 value of 6.5, 6.8 and 7.7 μg/mL, respectively. According to the results, some of these extracts might be further analyzed to develop effective anti-influenza factors.

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In vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract of Quercus brantii L. acorn and subsequent fractions

Cited by 24 publications

References 27 publications

A New Age forQuercusspp. Fruits: Review on Nutritional and Phytochemical Composition and Related Biological Activities of Acorns

A New Age forQuercusspp. Fruits: Review on Nutritional and Phytochemical Composition and Related Biological Activities of Acorns

Biochemical, Enzymatic, and Immunological Study on Antimutagenic Achillea millefolium Methanolic Extract in vivo

In vitro anti influenza virus activity, antioxidant potential and total phenolic content of twelve Iranian medicinal plants

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