In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)

Tellez, Mayra A.; Téllez, Alba N.; Velez, Fernando; Ulloa, Juan Carlos

doi:10.1186/s12906-015-0949-0

Cited by 20 publications

(13 citation statements)

References 37 publications

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“…Several recent studies demonstrate that plant extracts are deeply explored for their antiviral potential against HRoV [9–14, 27–29]. …”

Section: Discussionmentioning

confidence: 99%

“…One strategy is to explore plants as a source of novel active compounds due to the large structural diversity of natural products. Indeed, several studies reported on anti-HRoV activity by plant extracts [9–14]. In this context, we performed an antiviral screening of three plants endemic to Turkey flora and here we report on the anti-HRoV activity of Rindera lanata (Boraginaceae).…”

Section: Introductionmentioning

confidence: 92%

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In vitro screening for antiviral activity of Turkish plants revealing methanolic extract of Rindera lanata var. lanata active against human rotavirus

Civra

Francese

Sinato

et al. 2017

BMC Complement Altern Med

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BackgroundHuman rotavirus (HRoV) is the leading cause of severe gastroenteritis in infants and children under the age of five years. No specific antiviral drug is available for HRoV infections and the treatment of viral diarrhea is mainly based on rehydration and zinc treatment. In this study, we explored medicinal plants endemic to Turkey flora as a source of anti-HRoV compunds.MethodsWe performed an antiviral screening on Ballota macrodonta, Salvia cryptantha and Rindera lanata extracts by focus reduction assay. The extract with the highest selectivity index (SI) was selected; its antiviral activity was further confirmed against other HRoV strains and by virus yield reduction assay. The step of viral replicative cycle putatively inhibited was investigated by in vitro assays.ResultsThe methanolic extract of R. lanata (Boraginaceae) showed the most favourable selectivity index. This extract exhibited a dose-dependent inhibitory activity against three different HRoV strains (EC50 values ranging from 5.8 μg/ml to 25.5 μg/ml), but was inactive or barely active against other RNA viruses, namely human rhinovirus and respiratory syncytial virus. The R. lanata extract targets the early steps of HRoV infection, likely by hampering virus penetration into the cells.ConclusionThese results make the R. lanata methanolic extract a promising starting material for a bioguided-fractionation aimed at identifying anti-HRoV compounds. Further work is required to isolate the active principle and assess its clinical potential.

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“…Several recent studies demonstrate that plant extracts are deeply explored for their antiviral potential against HRoV [9–14, 27–29]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

In vitro screening for antiviral activity of Turkish plants revealing methanolic extract of Rindera lanata var. lanata active against human rotavirus

Civra

Francese

Sinato

et al. 2017

BMC Complement Altern Med

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“…Water treatments with chlorine and synthetic flavonoids have been proven to impair the multiplication of human astroviruses [ 121 , 151 ]; the effect of natural extracts from the plant Achyrocline bogotensis [ 152 ] on astrovirus replication has also been demonstrated, but none of these compounds have been tested in vivo.…”

Section: Control and Preventionmentioning

confidence: 99%

Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond

Bosch

Pintó

et al. 2017

Viruses

166

173

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Since they were identified in 1975, human astroviruses have been considered one of the most important agents of viral acute gastroenteritis in children. However, highly divergent astroviruses infecting humans have been recently discovered and associated with extra-intestinal infections. The report of cases of fatal meningitis and encephalitis, especially in immunocompromised individuals, has broadened their disease spectrum. Although zoonotic transmission among animal and human astroviruses has not been clearly recognized, the genetic similarity between some human and animal viruses makes it likely to occur. This review provides an update on the epidemiology of both classic and novel human astroviruses, and a comprehensive view on confirmed or potential association between astrovirus and human disease.

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“…In a Brazilian study, 4 species of medicinal plants were found to exhibit in vitro activity against rotaviruses [ 214 ]. In another in vitro study, fractions obtained from Achyrocline bogotensis were shown to exert a virucidal effect on rotaviruses and astroviruses, resulting in reduction of infectious viral particles [ 215 ]. Nutritional extracts of plants, such as Nelumbo nucifera Gaertn, Aspalathus linearis (Burm.f.)…”

Section: Rotavirus Therapeutics and Immunoprophylaxismentioning

confidence: 99%

Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future

Ghosh

Malik

Kobayashi

2018

CDM

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Background: Noroviruses and rotaviruses are important viral etiologies of severe gastroenteritis. Noroviruses are the primary cause of nonbacterial diarrheal outbreaks in humans, whilst rotaviruses are a major cause of childhood diarrhea. Although both enteric pathogens substantially impact human health and economies, there are no approved drugs against noroviruses and rotaviruses so far. On the other hand, whilst the currently licensed rotavirus vaccines have been successfully implemented in over 100 countries, the most advanced norovirus vaccine has recently completed phase-I and II trials.Methods: We performed a structured search of bibliographic databases for peer-reviewed research litera-ture on advances in the fields of norovirus and rotavirus therapeutics and immunoprophylaxis.Results: Technological advances coupled with a proper understanding of viral morphology and replication over the past decade has facilitated pioneering research on therapeutics and immunoprophylaxis against noroviruses and rotaviruses, with promising outcomes in human clinical trials of some of the drugs and vaccines. This review focuses on the various developments in the fields of norovirus and rotavirus thera-peutics and immunoprophylaxis, such as potential antiviral drug molecules, passive immunotherapies (oral human immunoglobulins, egg yolk and bovine colostral antibodies, llama-derived nanobodies, and anti-bodies expressed in probiotics, plants, rice grains and insect larvae), immune system modulators, probiot-ics, phytochemicals and other biological substances such as bovine milk proteins, therapeutic nanoparti-cles, hydrogels and viscogens, conventional viral vaccines (live and inactivated whole virus vaccines), and genetically engineered viral vaccines (reassortant viral particles, virus-like particles (VLPs) and other sub-unit recombinant vaccines including multi-valent viral vaccines, edible plant vaccines, and encapsulated viral particles).Conclusions: This review provides important insights into the various approaches to therapeutics and im-munoprophylaxis against noroviruses and rotaviruses..

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In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)

Cited by 20 publications

References 37 publications

In vitro screening for antiviral activity of Turkish plants revealing methanolic extract of Rindera lanata var. lanata active against human rotavirus

In vitro screening for antiviral activity of Turkish plants revealing methanolic extract of Rindera lanata var. lanata active against human rotavirus

Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond

Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future

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