In vitro Antiviral Activity of Nigella sativa against Peste des Petits Ruminants (PPR) Virus

Aqil, Kiran; Khan, Muti-ur-Rehman; Aslam, Asim; Javeed, Aqeel; Qayyum, Rizwan; Yousaf, Farooq; Yasmeen, Farkhanda; Sohail, Muhammad; Umar, Sajid

doi:10.17582/journal.pjz/2018.50.6.2223.2228

Cited by 14 publications

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“…The in vitro and in vivo studies of N.sativa has also shown antiviral efficacy against some other viruses like Murine cytomegalovirus (MCMV) [ 22 ], Papaya Ring Spot Virus [ 23 ], Hepatitis C Virus (HCV) [ 24 ], Avian influenza (H9N2) [ 25 ], Newcastle disease virus (NDV) [ 26 ] and Peste des Petits Ruminants (PPR) Virus [ 27 ]. It has been proposed that antiviral efficacy of N.sativa might be due to raised serum levels of interferon-gamma, increased CD4 count, augmented suppressor function and enhanced numbers of macrophages [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Maideen

2020

J Pharmacopuncture

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Section: Resultsmentioning

confidence: 99%

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Maideen

2020

J Pharmacopuncture

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“…[22][23][24] None of these studies, the antiviral activities for saffron extract and its main components affected, and Crocin and picrocrocin could be promising anti-HSV and anti-HIV agents for herbal treatment against vira infections. [25] In this study, the saffron plant with proven antiviral activity did not show antiviral effects against SARS-CoV-2. In our study, the cold press essential oil obtained from these ed of the Nigella plant (Nigella sativa L.) was ineffective in vitro conditions against SARS-CoV-2 at all concentrations following the initial concentration (Table 2).…”

Section: Discussionmentioning

confidence: 55%

Altı Tıbbi Bitkinin Sitotoksik Etkileri ve SARS-CoV-2'ye Karşı Antiviral Etkinliğinin Araştırılması

ISİK

Asil

ALP

et al. 2022

Journal of Contemporary Medicine

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Aim: Today, the COVID-19 pandemic, which causes deaths in 224 countries around the world, continues to show its effect all over the world. However, unfortunately, there are few studies that determine the effect of natural products derived from plants on COVID-19. However, as it is known, the source of most drugs is plants and medicinal aromatic plants have been used frequently for therapeutic purposes since the existence of humanity. The aim of this study is to investigate the cytotoxic effects of six medicinal plants such as Licorice (Glycyrrhiza glabra), Saffron (Crocus sativus L.), Black Cumin (Nigella sativa L.), Laurel (Lauris nobilis), Buckwheat (Lavandula stoechas) and Zahter (Thymbra spicata L. var. spicata) and their antiviral activities against SARS-CoV-2 in vitro conditions. Material and Method: This study was carried out in two stages. In the first stage, plants were collected and extracts were obtained. At the beginning of the second stage, cytotoxic effects on vero cells at non-cytotoxic broad-spectrum concentrations against SARS-CoV-2 in cell culture of six medicinal plants were investigated. In this step, the concentration of six ethnobotanically important medicinal plants that were not cytotoxic to SARS-CoV-2 was determined. In the continuation of the second stage, the plants were evaluated for the determination of viral replication inhibition and their antiviral effectiveness against SARS-CoV-2. In this step, in vitro antiviral effects of plants against SARS-CoV-2 were determined at a concentration that did not show cytotoxic effects.. Results: The concentration of six plants used in the study without cytotoxic effects was determined.. Among the plants examined, it was determined that the only plant that was effective against SARS-CoV-2 in vitro conditions was the licorice plant (Glycyrrhiza glabra). The licorice plant was found to inhibit SARS-CoV-2 in vitro at the 2nd dilution (1:4) after the initial concentration. Conclusion: According to the findings obtained from our study, it was determined that the licorice plant was effective against the SARS-CoV-2 in vitro conditions. Supported by further studies, it can be thought that our findings may contribute to the fight against the COVID-19 pandemic. Keywords: SARS-CoV-2, Antiviral Efficacy, Plant Extract, Licorice (Glycyrrhiza glabra), Saffron (Crocus sativus L.), Black Cumin (Nigella sativa L.), Laurel (Lauris nobilis), Buckwheat (Lavandula stoechas), Zahter (Thymbra spicata L. var. spicata).

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“…Hepatosit yang mengalami nekrosis akan melepaskan berbagai mediator yang akan memulai proses inflamasi dan menarik datangnya sel-sel radang. Adanya sel radang tersebut dapat diamati pada kelompok hewan coba yang diberi paparan organofosfat secara terus menerus (Aqil et al, 2018). Kerusakan hepatosit akibat pemberian organofosfat secara terus-menerus diduga akibat stres oksidatif.…”

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The Effect of Black Cumin (Nigella sativa) on Histopathology of Liver and Kidney in Albino Rats with Organophosphate Exposure

et al. 2023

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This study aimed to determine the effect of black cumin extract (Nigella sativa) on the histopathological of the liver and kidneys in albino rats exposed to organophosphates. This study used 20 male mice divided into five treatment groups, i.e. (K-) without organophosphate and black cumin, (K+) induced by organophosphate 40 mg/kg BW, treatment group induced by organophosphate 40 mg/kg BW and black cumin extract as therapy (P1 ) 200 mg/kg BW, (P2) 400 mg/kg BW, and (P3) 600 mg/kg BW. Organophosphate administration for eight weeks and black seed extract therapy was given for three weeks then the mice were euthanized, the liver and kidney organs were taken for histopathological observation using Haematoxylin-Eosin (HE). Data were analyzed using OneWay ANOVA test followed by Tukey test. The results showed that there were significant differences between the treatment groups for liver and kidney damage (p<0,05). Hepatic degeneration and necrosis in the P2 and P3 groups differed from K+ with an average of 2,24±0,9, in the kidneys with an average of 2,52±0,8. It can be concluded that black cumin extract has a significant effect on improving the liver and kidneys in groups P3 (600 mg/kgBW).

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In vitro Antiviral Activity of Nigella sativa against Peste des Petits Ruminants (PPR) Virus

Cited by 14 publications

References 0 publications

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Altı Tıbbi Bitkinin Sitotoksik Etkileri ve SARS-CoV-2'ye Karşı Antiviral Etkinliğinin Araştırılması

The Effect of Black Cumin (Nigella sativa) on Histopathology of Liver and Kidney in Albino Rats with Organophosphate Exposure

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