In vitro cytotoxicity, α-glucosidase inhibition, antioxidant, and free radical scavenging activities of Illicium griffithii Hook. f. &amp; Thoms fruits

Vijayakumar, Arunkumar; Jeyaraj, B.; Raj, M. Karunai; Christhudas, I.V.S. Nimal; Balachandran, C.; Agastian, Paul; Ignacimuthu, S.

doi:10.1007/s00044-013-0868-x

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…However, the inhibitors may possess various side effects such as flatulence, diarrhea, abdominal discomfort, and cell toxicities. [28][29][30] Therefore, there is considerable interest in the development of new and safer enzyme inhibitory agents. In this direction, many compounds have been reported as potential and safe enzyme inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin)

et al. 2015

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Objective: The aim of this work was to investigate the cytotoxic, antioxidative, and enzyme inhibition effects of alizarin, quinizarin, and purpurin, which are anthraquinones (AQ). Methods: Cytotoxic effects were evaluated with cell inhibition rate by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide assay. Different chemical assays, including free radical scavenging activity (1,1-diphenyl-2-picrylhydrazyl and 2,2-azino-bis(3-ethylbenzothiazloine-6-sulfonic acid)), phosphomolybdenum and reducing power (ferric reducing antioxidant power and cupric ion reducing activity), were used to evaluate the antioxidant properties. Moreover, enzyme inhibitory activities were analyzed against acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase. Results: These components have antioxidant and enzyme inhibition activity. Especially, purpurin showed the strongest antioxidant and good enzyme inhibitory effects. According to our cytotoxicity results, alizarin, purpurin, and quinizarin induced dose- and time-dependent cell proliferation. Furthermore, when we applied AQs with mitomycin C (MC) on L929 cell line, we demonstrated that cell proliferation in MC-AQ groups compared with MC group was increased. The most effective component was alizarin at 100 µM concentration. These AQs showed positive effects on L929 cell lines with high half-maximal inhibitory concentration values. Conclusion: Our results demonstrate that AQs may be used as antioxidative compounds in food and medicinal applications.

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Section: Discussionmentioning

confidence: 99%

Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin)

et al. 2015

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“…Many of them have several biological activities including enhanced choline acetyltransferase, anticancer, antiviral, antiinflammatory, and anti-HIV activities [ 5 – 8 ]. A literature survey depicts that, the fruit of I. griffithii has been shown to have anticancer [ 9 ], antimicrobial [ 10 ], and antioxidant [ 11 ] activities. In our earlier study, we have identified the fruit of I. griffithii as a rich source of Shikimic acid which is a raw material for the production of oseltavir (Tamiflu), the only drug available for swine flu and avian flu [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities

DUTTA¹,

NARZARY²,

SAIKIA³

et al. 2022

Turkish Journal of Chemistry

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Illicium griffithii Hook. f. & Thoms is an endemic medicinal plant of North East India found in the Eastern Himalayan region of biodiversity mega centre. Herein, chemical investigation of I. griffithii , afforded five compounds and their structures were determined through extensive use of NMR, HRMS, and FT-IR spectroscopy. The complete proton-proton, proton-carbon coupling network of compound 1 was determined using 1 H- 1 H COSY, HSQC and NOESY NMR experiments. All the compounds were evaluated for their cytotoxic activity by MTT assay and antimicrobial activity by Agar well diffusion method. Compound 1 exhibited significant cytotoxicity activity against Lung cancer (A549) and pancreatic cancer (MIAPaCa2) cell lines with IC 50 values of 15.01 ± 2.69 μg/mL and 47.77 ± 2.38 μg/mL, respectively. Further, the compound 1 exhibited good antimicrobial activities against Escherichia coli and Candida albicans with MIC 7.50 ± 0.28 μg/mL and 7.50 ± 0.86 μg/mL, respectively. The other isolated compounds along with the extracts of I. griffithii also displayed moderate anticancer and antimicrobial activities against respective strains. To the best of our knowledge, this is the first study of isolation of compounds from bark, wood, and leaf along with cytotoxicity and antimicrobial activities of I. griffithii from the North Eastern region of India and could be a potential herbal medicine in near future.

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“…Illicium griffithii is an important traditional medicinal plant, mainly found in Arunachal Pradesh, a Northeastern state of India. [13][14][15][16][17][18][19] Shikimic acid, isolated from the fruits of I. griffithii which is a starting material for the production of oseltamivir (Tamiflu) used against Avian Flu. 20 Therefore, it is a growing demand for I. griffithii species as a source of shikimic acid for the manufacture of anti-viral drugs.…”

Section: Introductionmentioning

confidence: 99%

The Valuable Medicinal Plants of Northeast India: Illicium griffithii Hook. f., Pothos scandens L. and Sarcostemma acidum (Roxb.) Voigt

2021

TJNPR

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In vitro cytotoxicity, α-glucosidase inhibition, antioxidant, and free radical scavenging activities of Illicium griffithii Hook. f. & Thoms fruits

Cited by 4 publications

References 38 publications

Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin)

Evaluation of antioxidant, enzyme inhibition, and cytotoxic activity of three anthraquinones (alizarin, purpurin, and quinizarin)

Major chemical constituents from Illicium griffithii Hook. f. & Thoms of North East India and their cytotoxicity and antimicrobial activities

The Valuable Medicinal Plants of Northeast India: Illicium griffithii Hook. f., Pothos scandens L. and Sarcostemma acidum (Roxb.) Voigt

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