In vitro degradation characteristics of photocrosslinked anhydride systems for bone augmentation applications

Weiner, Ashley A.; Shuck, Danielle M.; Bush, Jordan R.; Shastri, V. Prasad

doi:10.1016/j.biomaterials.2007.08.022

Cited by 40 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[41][42][43][44][45][46]. Most importantly, as we were searching for a candidate for the inorganic material for drug loading, drugs can be trapped within these hollow nano-CaCO 3 particles to effectively and efficiently deliver them to the tumors and cancer cells with some modifications [19,[47][48][49][50][51]. In the future, methods will be developed to synthesize featured hollow nano-CaCO 3 particles for drug loading and cancer therapy.…”

Section: Resultsmentioning

confidence: 99%

Rice-like hollow nano-CaCO 3 synthesis

Ulkeryildiz¹,

Kilic²,

Ozdemir³

2016

Journal of Crystal Growth

View full text Add to dashboard Cite

a b s t r a c tWe have shown that Ca(OH) 2 solution is a natural stabilizer for CaCO 3 particles. We designed a CO 2 bubbling crystallization reactor to produce nano-CaCO 3 particles in homogenous size distribution without aggregation. In the experimental set-up, the crystallization region was separated from the stabilization region. The produced nanoparticles were removed from the crystallization region into the stabilization region before aggregation or crystal growth. It was shown that rice-like hollow nano-CaCO 3 particles in about 250 nm in size were produced with almost monodispersed size distribution. The particles started to dissolve through their edges as CO 2 bubbles were injected, which opened-up the pores inside the particles. At the late stages of crystallization, the open pores were closed as a result of dissolution-recrystallization of the newly synthesized CaCO 3 particles. These particles were stable in Ca(OH) 2 solution and no aggregation was detected. The present methodology can be used in drug encapsulation into inorganic CaCO 3 particles for cancer treatment with some modifications.

show abstract

Section: Resultsmentioning

confidence: 99%

Rice-like hollow nano-CaCO 3 synthesis

Ulkeryildiz¹,

Kilic²,

Ozdemir³

2016

Journal of Crystal Growth

View full text Add to dashboard Cite

show abstract

“…Similarly, the Hubbell group's visible light-induced photopolymerizable glue, based on hydrolytically degradable poly(ethylene glycol) diacrylate derivatives and a visible light-induced photoradical generator (eosin Y), is now commercially available [3]. Other types of polymerizable biomacromolecule derivatives have also been reported [4][5][6][7][8][9][10][11][12][13][14][15][16]. However, these systems usually utilize synthetic polymerizable monomers as their major component.…”

Section: Introductionmentioning

confidence: 96%

Visible light-induced crosslinkable gelatin

et al. 2010

View full text Add to dashboard Cite

“…Patel et al 22 compared the viscosity, elastic, and viscous moduli of PEGDA hydrogel with human abdominal adipose tissue, finding that the PEGDA hydrogel was an appropriate candidate for initial implantation into the soft tissue defect. In the research of Weiner et al, 23 PEGDA (MW575 and MW700) as a reactive additive in the photocrosslinked polyanhydride (PA) networks improved the system properties for a bone replacement. Additionally, PEGDA-based products have also been successfully used for injectable drug delivery systems [24][25][26] and cell culture mediums.…”

mentioning

confidence: 99%

Controllable properties and microstructure of hydrogels based on crosslinked poly(ethylene glycol) diacrylates with different molecular weights

Zhang

Wang

Song

et al. 2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

This work describes a comprehensive study of hydrogels based on polyethylene glycol diacrylates (PEGDAs) with the molecular weight (MW) range of 400-2000. The blends of low-and high-molecular weight PEGDA macromers with different ratios were photopolymerized under visible light irradiation, using a blue light sensitive photoinitiator Irgacure819, at the total polymer concentration of 60 wt %. Swelling ratios, wetting property, elastic moduli, transparency, and the microstructure of the resulting hydrogels were investigated. Among them, equilibrium water contents, hydrophilicity, and mesh size of the hydrogels increased while the elastic moduli decreased when increased the PEGDA MW or the content of higher MW PEGDA in the blends. Most of the hydrogels possessed excellent transparency in visible region. The viability of L929 cells on the surface of hydrogel was also estimated. All the selected hydrogels exhibited a relatively high proliferation rate, which demonstrated this hydrogel system with photoinitiator Irgacure819 had good biocompatibility. These results show the properties of PEGDA hydrogel could be easily adjusted by varying PEGDA MW or the ratios of low-and high-MW macromers in the composites. It could be helpful for the design of proper PEGDA hydrogels in the applications as tissue engineering or drug delivery system.

show abstract

In vitro degradation characteristics of photocrosslinked anhydride systems for bone augmentation applications

Cited by 40 publications

References 25 publications

Rice-like hollow nano-CaCO 3 synthesis

Rice-like hollow nano-CaCO 3 synthesis

Visible light-induced crosslinkable gelatin

Controllable properties and microstructure of hydrogels based on crosslinked poly(ethylene glycol) diacrylates with different molecular weights

Contact Info

Product

Resources

About