In vitro degradation study of novel HEC/PVA/collagen nanofibrous scaffold for skin tissue engineering applications

Zulkifli, Farah Hanani; Hussain, Fathima Shahitha Jahir; Rasad, Mohammad Syaiful Bahari Abdull; Yusoff, Mashitah M.

doi:10.1016/j.polymdegradstab.2014.10.017

Cited by 68 publications

(30 citation statements)

References 31 publications

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“…Zulkifli et al [24] focused on the degradation behavior of nanofibrous scaffolds composed of HEC/PVAL (alcohol hydroxyethyl cellulose/polyvinyl alcohol) and HEC/PVAL/COL as potential substrates for the engineering of cutaneous tissues in two media (PBS) and Dulbecco's modified Eagle's medium (DMEM) for a period of 12 weeks of incubation. Once the scaffolds were characterized, the HEC/PVAL/COL scaffolds showed a slower degradation rate in both media compared to the HEC/PVAL blend nanofibers.…”

Section: Collagen Electrospinningmentioning

confidence: 99%

Gelatin and Collagen Nanofiber Scaffolds for Tissue Engineering

Monroy¹,

Bravo²,

Mercado³

et al. 2018

Tissue Regeneration

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One of the main complications that can present a person with second and third degree burns is the possibility of being infected by opportunistic bacteria or viruses that are present in the environment. Nowadays, the majority of the burn injuries are treated with conventional gauze, which involves a high probability of infection and pain for the patient being treated with this method. In order to obtain low-cost scaffolds, natural and abundant polymers were used such as gelatin (GEL) and collagen (COL). The GEL functions as a base scaffold, stable and flexible, and also biocompatible because it is a byproduct of the partial hydrolysis of COL, which is an indispensable component for the stability of the cell membrane and it is present in great extent in the human epithelium.

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Section: Collagen Electrospinningmentioning

confidence: 99%

Gelatin and Collagen Nanofiber Scaffolds for Tissue Engineering

Monroy¹,

Bravo²,

Mercado³

et al. 2018

Tissue Regeneration

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“…Additional concentration levels below the upper limit were selected at equal intervals. Two recent studies assessed the potential for coating tissue engineered scaffolds using PCL/chloroform solutions (Zulkifli et al, 2014;Shao et al, 2016). In these studies, 2.5 min and 10 min were used as the immersion times.…”

Section: Manufacturing Processmentioning

confidence: 99%

“…In these studies, 2.5 min and 10 min were used as the immersion times. To investigate the optimum immersion period for scaffolds to be coated with PCL -an extended range of immersion times was selected, which ranged from a relatively short period (30 s) to a prolonged period (30 min) compared to the previous studies (Zulkifli et al, 2014;Shao et al, 2016). The second PCL layer was applied onto each porous structure by repeating the same procedure as described for the first layer.…”

Section: Manufacturing Processmentioning

confidence: 99%

Effects of poly (ε-caprolactone) coating on the properties of three-dimensional printed porous structures

Zhou

Cunningham

Lennon

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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Powder-based inkjet three-dimensional printing (3DP) to fabricate pre-designed 3D structures has drawn increasing attention. However there are intrinsic limitations associated with 3DP technology due to the weak bonding within the printed structure, which significantly compromises its mechanical integrity. In this study, calcium sulphate ceramic structures demonstrating a porous architecture were manufactured using 3DP technology and subsequently post-processed with a poly (ε-caprolactone) (PCL) coating. PCL concentration, immersion time, and number of coating layers were the principal parameters investigated and improvement in compressive properties was the measure of success. Interparticle spacing within the 3DP structures were successfully filled with PCL material. Consequently the compressive properties, wettability, morphology, and in vitro resorption behaviour of 3DP components were significantly augmented. The average compressive strength, Young's modulus, and toughness increased 217%, 250%, and 315%, following PCL coating. Addition of a PCL surface coating provided long-term structural support to the host ceramic material, extending the resorption period from less than 7 days to a minimum of 56 days. This study has demonstrated that application of a PCL coating onto a ceramic 3DP structure was a highly effective approach to addressing some of the limitations of 3DP manufacturing and allows this advanced technology to be potentially used in a wider range of applications.

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“…At predetermined time intervals (1, 3, 5, 7, 14 days), the remaining sample was carefully removed from the well, rinsed using deionized water, dried at 60°C until the mass remained unchanged, and then weighed. The mass loss % was plotted vs. time to get the degradation profile of the membrane [13,14].…”

Section: Preparation Of Carbon Nano Fibers (Cnfs)mentioning

confidence: 99%

Study of In vitro Bioactivity and Biodegradability of the Hydrothermally Prepared Carbon Nanofibrous/Hydroxyapatite (Cnf/Ha) Membranes.

A¹,

Maghraby²,

Kandil³

2017

J Bone Res

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Critical size bone defects are orthopedic defects that will not heal without intervention or that will not completely heal over the natural life time of the animal. Although bone generally has the ability to regenerate completely however, critical defects need sort of scaffold to do so. In the current study, we proposed a method to get a Carbon NanoFibrous (CNFs) / Hydroxyapatite (HA) bioactive scaffold. The CNF nonwoven fabrics were obtained by the use of the electrospinning process of the polymeric solution of Poly Acrylonitrile (PAN) and next thermal treatment of both stabilization and carbonization processes, then the CNFs membranes were functionalized by (6.8 wt.%) HA by the hydrothermal process (130ºC for 90 min). The prepared membranes were in-vitro tested for bioactivity in Simulated Body Fluid (SBF) solution and for biodegradability in Phosphate Buffer Saline (PBS) solution. We have successfully prepared a bioactive and biodegradable membrane by immersing it in SBF and PBS solutions respectively for 14 days, where a bioactive layer of Hydroxy-Carbonated Apatite (HCA) was found on its surface. The formed layer of HCA has been characterized by XRD, FTIR, and SEM. The biodegradability of the membranes has been characterized by FTIR, SEM, and ICP for the PBS solution after different time intervals (1, 3, 5, 7 and 14) days. The membrane of (CNF/6%HA) is more biodegradable than other membranes of (CNF, and CNF/8%HA) (Figure 1).

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In vitro degradation study of novel HEC/PVA/collagen nanofibrous scaffold for skin tissue engineering applications

Cited by 68 publications

References 31 publications

Gelatin and Collagen Nanofiber Scaffolds for Tissue Engineering

Gelatin and Collagen Nanofiber Scaffolds for Tissue Engineering

Effects of poly (ε-caprolactone) coating on the properties of three-dimensional printed porous structures

Study of In vitro Bioactivity and Biodegradability of the Hydrothermally Prepared Carbon Nanofibrous/Hydroxyapatite (Cnf/Ha) Membranes.

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