In Vitro Dissolution of Metronidazole (400 Mg) Tablets: Effects of Lubricants on The Dissolution of Tablets

Perveen, Sajida; Hamid, Shaista; Usman, Shahnaz; Hassan, Sohail

doi:10.46624/ajptr.2018.v8.i1.015

Cited by 2 publications

(2 citation statements)

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“…The other formulations showed slight or minimum increases for their DTs, except for one notable formulation containing 0.5% MGS, in which the DT was significantly prolonged. This is a well-known phenomenon when MGS is used as a lubricant due to the formation of MGS films on other components in the formulation [ 7 , 8 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, some of these conventional lubricants possess disadvantages. MGS, for example, can negatively affect the tensile strength, disintegration, and dissolution of tablets, thus compromising the bioavailability and efficacy of the drugs [ 6 , 7 , 8 ]. Stearic acid can cause the tablets to become sticky and difficult to handle during the manufacturing process.…”

Section: Introductionmentioning

confidence: 99%

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Utilization and Evaluation of Rice Bran and Rice Bran Wax as a Tablet Lubricant

Kittipongpatana,

Trisopon,

Wattanaarsakit

et al. 2024

Pharmaceutics

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The rice bran and rice bran wax of the KJ CMU107 rice strain were investigated as potential tablet lubricants in a directly compressed tablet formulation. Stabilized full-fatted rice bran (sFFRB), stabilized defatted rice bran (sDFRB), and rice bran wax (RBW) extracted and purified from crude rice bran oil (cRBO) were tested. Two commercial lubricants, including magnesium stearate (MGS) and hydrogenated cottonseed oil (HVO), were employed as the standards in the formulated mixtures, which contained spray-dried rice starch (SDRS) as a diluent. The tableting was carried out for each formulation, and the obtained tablets were physically and mechanically evaluated. Among the parameters investigated were the general appearance, ejection force, weight variation, hardness, friability, and disintegration time. The powder flow was also determined for each formulation. The results showed that the tablet ejection forces for all the lubricated formulations (58–259 N) were significantly lower than that of the non-lubricated control formulation (349 N). The use of sFFRB as a lubricant at 0.5–2.0% w/w could lower the ejection force up to 78%, but the hardness reduced so drastically that the formulations failed the friability test due to the chipping of the tablets’ edges. Moreover, sDFRB performed significantly better as the use at 0.5–1.0% w/w in the formulation helped to lower the ejection forces by up to 80% while maintaining the changes in the tablet hardness within 10%. RBW functioned effectively as a tablet lubricant at a concentration of 0.5% w/w, yielding tablets with good strength comparable to standard HVO lubricant while helping to reduce the ejection force by 82%. In formulations with good lubrication, i.e., friability < 1%, the powder flow was improved, and the tablet disintegration times were within the same range as the control and HVO formulations. In conclusion, sDFRB displayed a lubricant property at concentrations between 0.5 and 1.0% w/w, with slightly negative effects on the tablet hardness. RBW from KJ CMU107 rice was an effective tablet lubricant at 0.5% w/w, with no effect on tablet hardness. Both materials can be further developed for use as commercial lubricants in direct compression.

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Section: Resultsmentioning

confidence: 99%