In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability

Dey, Baishakhi; Katakam, Prakash; Assaleh, Fathi H.; Chandu, Babu Rao; Adiki, Shanta Kumari; Mitra, Analava

doi:10.1016/j.jpha.2015.02.003

Cited by 11 publications

(6 citation statements)

References 26 publications

(54 reference statements)

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“…Also ciprofloxacin graded doses alone showed antibacterial activity against all the test organisms. However, (22). The antagonistic action in our study may be also due to variation in the composition of camel milk which depends on the season, lactation period, feeding conditions, and water availability when compared to synergistic finding reported by Yassin 2015 (6).…”

Section: Discussionsupporting

confidence: 42%

Influence of Camel Milk on the Antibacterial Activity of Ciprofloxacin

Tanko¹,

Jimoh²,

Umar³

et al. 2021

ABMS

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Background: Despite the availability of more researched and formulated orthodox medicines, traditional medicines remain the main source of therapy for the majority of people worldwide with some patrons concurrently using both forms unaware of the unwanted effects that may occur. Camel milk is often used alone or in combination with other orthodox medications to treat diseases. The study aimed to investigate the influence of camel milk on the antibacterial activity of ciprofloxacin. Materials and methods: The in vitro antibacterial activity of camel milk escalating doses (30μL, 100μL and 300μL) alone and in combination with Ciprofloxacin escalating doses (2mcg, 5mcg, 15mcg) against some clinical bacterial isolates (Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Serratia marcescens) was determined using the Agar-well diffusion method. Result: Camel milk escalating doses alone showed dose-dependent antibacterial effect against all the test bacteria. However, combinations of the camel milk escalating doses and ciprofloxacin escalating doses respectively produced an antagonistic effect against all the test organisms. Conclusion: Fresh camel milk possesses antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens and Staphylococcus aureus but is not recommended for combination with ciprofloxacin to treat infections caused by the above organisms.

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Section: Discussionsupporting

confidence: 42%

Influence of Camel Milk on the Antibacterial Activity of Ciprofloxacin

Tanko¹,

Jimoh²,

Umar³

et al. 2021

ABMS

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“…Data analysis was performed by calculating percent release of sitagliptin when treated alone and in presence of different antacids using following formula (Dey et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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Hyperglycemia is a long-lasting syndrome that occurs either when the pancreas cannot produce enough insulin, or the body cannot effectively utilize that insulin to regulate blood sugar levels. Non-insulin-dependent hyperglycemia, also known as type II diabetes, causes a common consequence of severe damage to many of the body's organs mainly the blood vessels and nerves. The majority of people around the world are suffering from non-insulindependent diabetes. The present work showed a great effort to investigate any possible interaction between antacids and sitagliptin (anti-diabetic drug) in the treatment of type II diabetes with gastrointestinal tract problems. The in vitro studies were carried out in simulated gastric juice pH 2.0 and intestinal pH 7.4 at 37C. MgCO 3 , NaHCO 3 , Mg(OH) 2 , Al(OH) 3 and CaCO 3 were used as antacids in these studies. It has been observed that % release of sitagliptin was significantly enhanced in the presence of calcium carbonate and magnesium carbonates.

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“…High-protein meals can enhance presystemic metabolism by inducing catabolic enzymes, which degrade oral-administrated bioactive compounds. 36,37 The solubility of lipophilic drugs is enhanced by fats contained in milk. 38 In this study, milk significantly reduced the AUC values of Cur-NE but showed no remarkable effects on the AUC values of Cur-SS, Cur-SWNT, and Cur-NLC.…”

Section: Discussionmentioning

confidence: 99%

Effects of food matrix and probiotics on the bioavailability of curcumin in different nanoformulations

et al. 2021

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BACKGROUND: Nanoparticles can improve the bioavailability of bioactive compounds. Concomitant intake of food can affect pharmacokinetic profiles by altering dissolution, absorption, metabolism, and elimination behavior. Studies on the effects of food and its supplements on the bioavailability of bioactives in nanoformulations are few. In this study, the effects of typical food (milk, sugar, high-fat diet, and regular kibble) and a widely consumed probiotic [Bifidobacterium lactis Bb-12® (Bb-12)] on the bioavailability of curcumin in four formulations [simply suspended curcumin (Cur-SS) and curcumin in nanoemulsions (Cur-NEs), in single-walled carbon nanotubes (Cur-SWNTs), and in nanostructured lipid carriers (Cur-NLCs)] were investigated.RESULTS: Fasting treatment and sugar co-ingestion can significantly enhance the bioavailability of curcumin in Cur-NEs and Cur-SWNTs, respectively. Compared with the fasting treatment, co-ingestion with regular kibble reduced the absorption of curcumin in Cur-NEs and Cur-SWNTs. Ingesting milk along with Cur-NE is also not recommended. The mechanisms behind these phenomena were briefly discussed. This study revealed for the first time that the intestinal colonization of Bb-12 reduces the bioavailability of curcumin and this reduction can be attenuated by nanoformulations SWNTs and NLCs, but not NEs. The reason for this difference was the protective effects of the former two nanoformulations against curcumin degradation by Bb-12 according to in vitro experiments. CONCLUSION: Dietary status (including supplementary probiotics) can dramatically influence the bioavailability of curcumin in nanoformulations.

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In vitro–in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability

Cited by 11 publications

References 26 publications

Influence of Camel Milk on the Antibacterial Activity of Ciprofloxacin

Influence of Camel Milk on the Antibacterial Activity of Ciprofloxacin

Untitled

Effects of food matrix and probiotics on the bioavailability of curcumin in different nanoformulations

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