Background and Objective: Camel milk, a dairy product different from other ruminant milk is commonly consumed in Nigeria and other parts of Africa, Asia and the Middle East not only for its nutritional value but also for its potential therapeutic effects including antidiabetics, anticarcinogenic, amongst other indications. In Northern Nigeria, camel milk is used alone or in combination with orthodox medicine for treating diabetes mellitus. This study was carried out to investigate the influence of concurrent administration of fresh camel milk with Metformin in alloxan-induced diabetic Wister rats. Synergistic activity between the Metformin-camel milk combination was also assessed using internationally accepted synergy analysis models (loewe additivity, bliss independence and highest single agent). Materials and Methods: Eleven groups of Wistar rats (n = 6) were formed for the study. Out of the eleven groups, ten were rendered diabetic by intraperitoneal injection of alloxan 150 mg kgG 1 stat and one left as control. Six groups were administered with either the camel milk or the Metformin at 3 different doses each (0.5, 1 and 1.5 mL kgG 1 for the camel milk and 50, 100 and 300 mg kgG 1 for Metformin), while another 3 groups were co-administered with the camel milk and Metformin at 3 different ratios each (0.5 mL kgG 1 :50 mg kgG 1 , 1 mL kgG 1 :100 mg kgG 1 and 1.5 mL kgG 1 :300 mg kgG 1 ) fasting blood glucose was carried out on day 14. Results: Synergistic activity of the camel milk and Metformin combination in reducing fasting blood glucose (based on Loewe, HSA and Bliss model). Conclusion: The combination therapy of camel milk and Metformin was synergistic in reducing hyperglycemia.

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Background: Despite the availability of more researched and formulated orthodox medicines, traditional medicines remain the main source of therapy for the majority of people worldwide with some patrons concurrently using both forms unaware of the unwanted effects that may occur. Camel milk is often used alone or in combination with other orthodox medications to treat diseases. The study aimed to investigate the influence of camel milk on the antibacterial activity of ciprofloxacin. Materials and methods: The in vitro antibacterial activity of camel milk escalating doses (30μL, 100μL and 300μL) alone and in combination with Ciprofloxacin escalating doses (2mcg, 5mcg, 15mcg) against some clinical bacterial isolates (Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Serratia marcescens) was determined using the Agar-well diffusion method. Result: Camel milk escalating doses alone showed dose-dependent antibacterial effect against all the test bacteria. However, combinations of the camel milk escalating doses and ciprofloxacin escalating doses respectively produced an antagonistic effect against all the test organisms. Conclusion: Fresh camel milk possesses antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens and Staphylococcus aureus but is not recommended for combination with ciprofloxacin to treat infections caused by the above organisms.