Influence of Camel Milk on the Hypoglycemic Effect of Metformin in Diabetic Rats

Abstract

Background and Objective: Camel milk, a dairy product different from other ruminant milk is commonly consumed in Nigeria and other parts of Africa, Asia and the Middle East not only for its nutritional value but also for its potential therapeutic effects including antidiabetics, anticarcinogenic, amongst other indications. In Northern Nigeria, camel milk is used alone or in combination with orthodox medicine for treating diabetes mellitus. This study was carried out to investigate the influence of concurrent administration of fresh camel milk with Metformin in alloxan-induced diabetic Wister rats. Synergistic activity between the Metformin-camel milk combination was also assessed using internationally accepted synergy analysis models (loewe additivity, bliss independence and highest single agent). Materials and Methods: Eleven groups of Wistar rats (n = 6) were formed for the study. Out of the eleven groups, ten were rendered diabetic by intraperitoneal injection of alloxan 150 mg kgG 1 stat and one left as control. Six groups were administered with either the camel milk or the Metformin at 3 different doses each (0.5, 1 and 1.5 mL kgG 1 for the camel milk and 50, 100 and 300 mg kgG 1 for Metformin), while another 3 groups were co-administered with the camel milk and Metformin at 3 different ratios each (0.5 mL kgG 1 :50 mg kgG 1 , 1 mL kgG 1 :100 mg kgG 1 and 1.5 mL kgG 1 :300 mg kgG 1 ) fasting blood glucose was carried out on day 14. Results: Synergistic activity of the camel milk and Metformin combination in reducing fasting blood glucose (based on Loewe, HSA and Bliss model). Conclusion: The combination therapy of camel milk and Metformin was synergistic in reducing hyperglycemia.

Antioxidant potential of resveratrol on plasmodium berghei-induced malaria in diabetic male Wistar rats

“…The counts of the parasitemia in the resveratrol groups were reasonably decrease when compared to those of the diabetic controls and HFD by the 6 th day. The observed decrease may be due to the anti-diabetic activities of resveratrol on parasitemia rats as described by [31], who demonstrated the effect of resveratrol on parasitaemia in Plasmodium bergheiinduced malaria in diabetic male Wistar rats. The result shows that parasitemia counts were remarkably higher across the groups when the effect of time and treatment were assessed, and the results for HFD, vitamin C and resveratrol groups agreed with the ndings of [2,18,27], respectively.…”