In Vitro Interactions between DMSA-Coated Maghemite Nanoparticles and Human Fibroblasts:  A Physicochemical and Cyto-Genotoxical Study

Auffan, Mélanie; Decome, Laetitia; Rose, Jérôme; Orsière, Thierry; Méo, Michel De; Briois, Valérie; Chanéac, Corinne; Olivi, Luca; Bergé-Lefranc, Jean-Louis; Botta, A.; Wiesner, Mark R.; Bottero, Jean‐Yves

doi:10.1021/es060691k

Cited by 192 publications

(128 citation statements)

References 32 publications

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“…If, however, the surface of the particles is totally covered, the dispersion may be stabilized, which will reduce the aggregation induced by both electrochemical and steric interactions [34]. Electrostatic modifications of colloidal stability can also occur after chemisorption of small inorganic or organic molecules [35]. Furthermore, the particle may adsorb contaminants or small biological entities and act as a vector for their transport in the environment [36][37][38][39][40].…”

Section: Nanoparticle Releasementioning

confidence: 99%

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Nowack¹,

Ranville²,

Diamond³

et al. 2011

Enviro Toxic and Chemistry

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533

353

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Abstract-The risks associated with exposure to engineered nanomaterials (ENM) will be determined in part by the processes that control their environmental fate and transformation. These processes act not only on ENM that might be released directly into the environment, but more importantly also on ENM in consumer products and those that have been released from the product. The environmental fate and transformation are likely to differ significantly for each of these cases. The ENM released from actual direct use or from nanomaterial-containing products are much more relevant for ecotoxicological studies and risk assessment than pristine ENM. Released ENM may have a greater or lesser environmental impact than the starting materials, depending on the transformation reactions and the material. Almost nothing is known about the environmental behavior and the effects of released and transformed ENM, although these are the materials that are actually present in the environment. Further research is needed to determine whether the release and transformation processes result in a similar or more diverse set of ENM and ultimately how this affects environmental behavior. This article addresses these questions, using four hypothetical case studies that cover a wide range of ENM, their direct use or product applications, and their likely fate in the environment. Furthermore, a more definitive classification scheme for ENM should be adopted that reflects their surface condition, which is a result of both industrial and environmental processes acting on the ENM. The authors conclude that it is not possible to assess the risks associated with the use of ENM by investigating only the pristine form of the ENM, without considering alterations and transformation processes. Environ. Toxicol. Chem. 2012;31:50-59. # 2011 SETAC

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Section: Nanoparticle Releasementioning

confidence: 99%

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Nowack¹,

Ranville²,

Diamond³

et al. 2011

Enviro Toxic and Chemistry

Self Cite

533

353

View full text Add to dashboard Cite

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“…Several previous studies examined the effects of DMSA-MNP on different cell types, and showed little reduction in cell viability [11,16,40]. These studies used low MNP doses, however, or incubation times too short to permit analysis of all possible toxic effects of iron oxide nanoparticles.…”

Section: In Vitro Dmsa-mnp Cytotoxicitymentioning

confidence: 99%

“…Previous studies analyzed in vitro toxicity of several kinds of iron oxide MNP on different cell types, with variable results. Whereas some showed that MNP can reduce cell viability, affect cell morphology or adhesion, or impair cell metabolism [6,[11][12][13], others found no significant cytotoxic effects [14][15][16]. These contradictory results are closely related to a concept known as "cell vision", refering to the contact point between nanoparticles and cells.…”

Section: Introductionmentioning

confidence: 99%

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Mejías

Gutiérrez

Salas

et al. 2013

Journal of Controlled Release

122

106

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Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little is known about their biotransformation and long-term toxicity in the body. Dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles have been proven efficient for in vivo drug delivery, but these results must nonetheless be sustained by comprehensive studies of long-term distribution, degradation and toxicity. We studied DMSA-coated magnetic nanoparticles effects in vitro on NCTC 1469 nonparenchymal hepatocytes, and analyzed their biodistribution and biotransformation in vivo in C57BL/6 mice. Our results indicate that DMSA-coated magnetic nanoparticles have little effect on cell viability, oxidative stress, cell cycle or apoptosis on NCTC 1469 cells in vitro. In vivo distribution and transformation was studied by alternating current magnetic susceptibility measurements, a technique that permits distinction of MNP from other iron species. Our results show that DMSA-coated MNP accumulate in spleen, liver and lung tissues for extended periods of time, in which nanoparticles undergo a process of conversion from superparamagnetic iron oxide nanoparticles to other nonsuperparamagnetic iron forms, with no significant signs of toxicity.

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“…412 We summarize the characterization of nanoparticles and the cell models used in all of these studies in Table 5. The genotoxic potential of other nanoparticles, such as QD, 414 nanodiamonds, 413 aluminum oxide, 172 cobalt, 400 cobalt chrome alloy, 415 and maghemite nanoparticles, 416 have also been investigated. However, comparison of these results is difficult because of the great differences in the experimental protocols used.…”

mentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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In Vitro Interactions between DMSA-Coated Maghemite Nanoparticles and Human Fibroblasts: A Physicochemical and Cyto-Genotoxical Study

Cited by 192 publications

References 32 publications

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Perturbation of physiological systems by nanoparticles

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