In vitro PAMAM, phosphorus and viologen-phosphorus dendrimers prevent rotenone-induced cell damage

Miłowska, Katarzyna; Szwed, Aleksandra; Zabłocka, Maria; Caminade, Anne‐Marie; Majoral, Jean‐Pierre; Mignani, Serge; Gabryelak, Teresa; Bryszewska, Maria

doi:10.1016/j.ijpharm.2014.08.010

Cited by 25 publications

(14 citation statements)

References 35 publications

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“…All dendrimers reduced cell death compared with untreated controls. A lower level of ROS and a favorable effect on mitochondrial system were also observed [89]. dendrimers inhibited the activities of both cholinesterases, showing their potential as new drugs for treating neurodegenerative diseases [85].…”

Section: Functions As Constituents Of the Branches At One Or Several mentioning

confidence: 84%

“…All dendrimers reduced cell death compared with untreated controls. A lower level of ROS and a favorable effect on mitochondrial system were also observed [89]. Other types of dendrimers incorporating viologen units in their structure have been recently obtained, as new examples of the synthetic "onion peel" [90] approach, i.e., dendritic compounds having different types of layers.…”

Section: Functions As Constituents Of the Branches At One Or Several mentioning

confidence: 93%

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Bifunctional Phosphorus Dendrimers and Their Properties

Caminade

Majoral

2016

Molecules

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Dendrimers are hyperbranched and monodisperse macromolecules, generally considered as a special class of polymers, but synthesized step-by-step. Most dendrimers have a uniform structure, with a single type of terminal function. However, it is often desirable to have at least two different functional groups. This review will discuss the case of bifunctional phosphorus-containing dendrimers, and the consequences for their properties. Besides the terminal functions, dendritic structures may have also a function at the core, or linked off-center to the core, or at the core of dendrons (dendritic wedges). Association of two dendrons having different terminal functions leads to Janus dendrimers (two faces). The internal structure can also possess functional groups on one layer, or linked to one layer, or on several layers. Finally, there are several ways to have two types of terminal functions, besides the case of Janus dendrimers: either each terminal function bears two functions sequentially, or two different functions are linked to each terminal branching point. Examples of each type of structure will be given in this review, as well as practical uses of such sophisticated structures in the fields of fluorescence, catalysis, nanomaterials and biology.

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Section: Functions As Constituents Of the Branches At One Or Several mentioning

confidence: 84%

Section: Functions As Constituents Of the Branches At One Or Several mentioning

confidence: 93%

Bifunctional Phosphorus Dendrimers and Their Properties

Caminade

Majoral

2016

Molecules

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“…The dendrimers tested here were PAMAM dendrimers, PPH dendrimers, and small viologen-phosphorus dendrimers [ 42 , 43 ]. These dendrimers increased cell viability, decreased ROS production, and preserved the mitochondrial function [ 44 ].…”

Section: Phosphorhydrazone Dendrimers Compared To Other Types Of Dmentioning

confidence: 99%

Which Dendrimer to Attain the Desired Properties? Focus on Phosphorhydrazone Dendrimers

Caminade

Majoral

2018

Molecules

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Among the six Critical Nanoscale Design Parameters (CNDPs) proposed by Prof. Donald A. Tomalia, this review illustrates the influence of the sixth one, which concerns the elemental composition, on the properties of dendrimers. After a large introduction that summarizes different types of dendrimers that have been compared with PolyAMidoAMine (PAMAM) dendrimers, this review will focus on the properties of positively and negatively charged phosphorhydrazone (PPH) dendrimers, especially in the field of biology, compared with other types of dendrimers, in particular PAMAM dendrimers, as well as polypropyleneimine (PPI), carbosilane, and p-Lysine dendrimers.

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“…On the other hand, viologen derivatives are often used in wet‐type solar cells and biomimetic systems such as electron‐transfer receptor sites in zinc‐reconstituted myoglobin . Furthermore, methyl viologen (MV) is a well‐known causative agent for Parkinson's disease; even a small amount (0.23 mmol) of MV can significantly affect the human body .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Condensation of Methylviologen on Specifically‐adsorbed Anion Layers

et al. 2019

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The adsorption of methylviologen dications (MV2+) on single‐crystalline Au electrodes in both H2SO4 and HClO4 was examined. MV2+ strongly interacted with sulfate and bisulfate anions adsorbed on the Au(111) electrode surface in 0.05 M H2SO4 under a controlled potential of 1.25 V vs. the reversible hydrogen electrode (RHE). A characteristic non‐Faradaic current was observed at 1.10 V vs. RHE. When adsorption of MV2+ was carried out in 0.1 M HClO4, the electrochemical response of MV2+ was less than that obtained in H2SO4. The results show that the formation of a highly ordered sulfate/bisulfate adlayer plays an important role in the formation of condensed MV2+ layers. Examination of polycrystalline Au and Au(100) electrodes revealed a poor electrochemical response due to the surface roughness of the Au substrate, but the electrochemical detection was applicable to polycrystalline Au electrodes. A systematic investigation of the structural dependency of viologen derivatives showed that molecular size is important for electrostatic interactions with a highly ordered sulfate/bisulfate adlayer. The findings of the present study demonstrate successful detection of MV2+ at a concentration of ≤1 pM with a non‐Faradaic current.

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In vitro PAMAM, phosphorus and viologen-phosphorus dendrimers prevent rotenone-induced cell damage

Cited by 25 publications

References 35 publications

Bifunctional Phosphorus Dendrimers and Their Properties

Bifunctional Phosphorus Dendrimers and Their Properties

Which Dendrimer to Attain the Desired Properties? Focus on Phosphorhydrazone Dendrimers

Electrochemical Condensation of Methylviologen on Specifically‐adsorbed Anion Layers

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