In vitro studies of closed-loop feedback and electrosensory processing in Apteronotus leptorhynchus

Mileva, Gerri; Zysman, Daniel; Groothuis, Sally; Lewis, John E.

doi:10.1016/j.jphysparis.2008.10.012

Cited by 4 publications

(1 citation statement)

References 66 publications

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“…Stimuli delivered to the fish are typically pre-recorded from other animals, which means that changes in the response of the fish to the stimuli are not considered in these experiments. Closed-loop experiments in weakly electric fish have been mostly used to address navigation [ 24 ], jamming avoidance response models [ 26 ], in dynamic clamp in vitro studies [ 27 ] and to characterize the echo response [ 10 , 14 , 16 ]. The pioneering experiments with echo response were typically studied using artificial EOD timings with square pulses and fish confined in narrow cages.…”

Section: Discussionmentioning

confidence: 99%

Delay-Dependent Response in Weakly Electric Fish under Closed-Loop Pulse Stimulation

et al. 2015

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In this paper, we apply a real time activity-dependent protocol to study how freely swimming weakly electric fish produce and process the timing of their own electric signals. Specifically, we address this study in the elephant fish, Gnathonemus petersii, an animal that uses weak discharges to locate obstacles or food while navigating, as well as for electro-communication with conspecifics. To investigate how the inter pulse intervals vary in response to external stimuli, we compare the response to a simple closed-loop stimulation protocol and the signals generated without electrical stimulation. The activity-dependent stimulation protocol explores different stimulus delivery delays relative to the fish’s own electric discharges. We show that there is a critical time delay in this closed-loop interaction, as the largest changes in inter pulse intervals occur when the stimulation delay is below 100 ms. We also discuss the implications of these findings in the context of information processing in weakly electric fish.

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Section: Discussionmentioning

confidence: 99%

Delay-Dependent Response in Weakly Electric Fish under Closed-Loop Pulse Stimulation

et al. 2015

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Short-term synaptic plasticity across topographic maps in the electrosensory system

2016

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Neural population densities shape network correlations

Lefebvre

Perkins

2012

Phys. Rev. E

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The way sensory microcircuits manage cellular response correlations is a crucial question in understanding how such systems integrate external stimuli and encode information. Most sensory systems exhibit heterogeneities in terms of population sizes and features, which all impact their dynamics. This work addresses how correlations between the dynamics of neural ensembles depend on the relative size or density of excitatory and inhibitory populations. To do so, we study an apparently symmetric system of coupled stochastic differential equations that model the evolution of the populations' activities. Excitatory and inhibitory populations are connected by reciprocal recurrent connections, and both receive different stimuli exhibiting a certain level of correlation with each other. A stability analysis is performed, which reveals an intrinsic asymmetry in the distribution of the fixed points with respect to the threshold of the nonlinearities. Based on this, we show how the cross correlation between the population responses depends on the density of the inhibitory population, and that a specific ratio between both population sizes leads to a state of zero correlation. We show that this so-called asynchronous state subsists, despite the presence of stimulus correlation, and most importantly, that it occurs only in asymmetrical systems where one population outnumbers the other. Using linear approximations, we derive analytical expressions for the root of the cross-correlation function and study how the asynchronous state is impacted by the model's parameters. This work suggests a possible explanation for why inhibitory cells outnumber excitatory cells in the visual system.

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In vitro studies of closed-loop feedback and electrosensory processing in Apteronotus leptorhynchus

Cited by 4 publications

References 66 publications

Delay-Dependent Response in Weakly Electric Fish under Closed-Loop Pulse Stimulation

Delay-Dependent Response in Weakly Electric Fish under Closed-Loop Pulse Stimulation

Short-term synaptic plasticity across topographic maps in the electrosensory system

Neural population densities shape network correlations

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