In Vitro Susceptibilities of the Bacteroides fragilis Group Species: Change in Isolation Rates Significantly Affects Overall Susceptibility Data

Abstract

A comparison of antimicrobial susceptibility data of species of the Bacteroides fragilis group for 1989-1990 and 1998-1999 studies showed statistically significant increases or decreases in in vitro activity. Overall significant increases in resistance were noted for ampicillin-sulbactam and clindamycin, while significant decreases in resistance were noted for ertapenem and cefoxitin. Susceptibilities to piperacillin-tazobactam, imipenem, meropenem, and trovafloxacin remained virtually the same for the two studies. Importantly, a change in the rates of isolation of the various species showed the B. fragilis species comprised 58% of the isolates in 1989 to 1990 and 45% of the isolates in 1998 to 1999. This change in rates of isolation of B. fragilis versus non-B. fragilis species had an overall effect on susceptibility data.

Antimicrobial Therapy for Acute Colonic Diverticulitis

“…Traditionally, these agents were considered equally efficacious, a concept supported by data from older prospective trials. However, more recent in vitro data have demonstrated increasing resistance of B. fragilis and other anaerobic bacteria to clindamycin [66,67]. Although there have been no studies demonstrating that these changes in resistance have led to poorer clinical outcomes, this possibility remains a concern for some practitioners.…”

Seleção e uso de antibióticos em infecções intra-abdominais

“…Porém, para outras infecções, como as de cólon, há maior chance de falha se a antibioticoterapia não for dirigida contra os germes isolados (3,11) . Com relação a bactérias anaeróbias, há maior e crescente resistência para a clindamicina, cefoxitina, piperacilina e quinolonas (1,11) . Nas infecções após cirurgias eletivas ou de emergência, a fl ora encontrada é geralmente mais resistente.…”

Identification of Bacteroides thetaiotaomicron on the Basis of an Unexpected Specific Amplicon of Universal 16S Ribosomal DNA PCR

“…They are opportunistic pathogens commonly associated with peritonitis, septicemia, and wound infections (3,8). Although B. thetaiotaomicron is part of the indigenous microflora of the gastrointestinal tract, it may cause serious infections such as intra-abdominal sepsis and bacteremia (1,3,8). B. thetaiotaomicron is resistant to many antimicrobial agents; for example, it has been reported to be more resistant than B. fragilis to cephalosporins and clindamycin (1,9,10,12).…”

“…Although B. thetaiotaomicron is part of the indigenous microflora of the gastrointestinal tract, it may cause serious infections such as intra-abdominal sepsis and bacteremia (1,3,8). B. thetaiotaomicron is resistant to many antimicrobial agents; for example, it has been reported to be more resistant than B. fragilis to cephalosporins and clindamycin (1,9,10,12). Therefore, rapid and accurate identification of B. thetaiotaomicron in clinical specimens is important, and it may help physicians make rational, rapid choices with respect to antibiotic therapy.…”

“…fragilis and B. thetaiotaomicron are clinically important because they are the first and second most common agents of infections caused by anaerobic gram-negative bacilli, respectively (1,3,8). They are opportunistic pathogens commonly associated with peritonitis, septicemia, and wound infections (3,8).…”