In vitro tests and ethnopharmacological investigations: Wound healing as an example

Houghton, Peter J.; Hylands, Peter J.; Mensah, Abraham Yeboah; Hensel, Andreas; Deters, Alexandra

doi:10.1016/j.jep.2005.07.001

Cited by 286 publications

(220 citation statements)

References 21 publications

(28 reference statements)

Supporting

Mentioning

210

Contrasting

Unclassified

Order By: Relevance

“…Flavonoids has played as important role as wound healing due to its anti-inflammatory potential through NFκB synthesis inhibition. 11,12 The literature review suggest that Clinacanthus nutans and Elephantopus scaber has antioxidant properties, which may be responsible and constructive for faster wound healing. [13][14][15] Further investigation on new poly herbal formulation in the treatment of wound and isolation of bioactive compounds is currently in progress.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Evaluation of Polyherbal Formulation of Clinacanthus nutans and Elephantopus scaber to Identify Flavonoids

Aslam¹,

Ahmad²,

Mamat³

2016

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Phytochemical Evaluation of Polyherbal Formulation of Clinacanthus nutans and Elephantopus scaber to Identify Flavonoids

Aslam¹,

Ahmad²,

Mamat³

2016

View full text Add to dashboard Cite

“…More than 80% of the world's population utilizes traditional medicines for various skin diseases [11]. Recently, the traditional usage of plants has received considerable attention for wound healing by the scientific community [11,12]. Approximately, one-third of all using traditional medicines are for the treatment of wounds and skin disorders, compared to only 1-3% of modern drugs [13,14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Amygdalus eburnea on third degree burns in rats and comparison with silver sulfadiazine ointment

Rezaeifar

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Amygdalus eburnea is a perennial herb that has been valued for its important biological perspectives and it has been used to treat the burn. This study aims to evaluate wound healing activity of A. eburnea extract compared with silver sulfadiazine (a synthetic burn ointment) for treating the induced third-degree burn in rat. Methods:In this study, a deep, third-degree burn wound was induced by a hot plate warmed 5 minutes within boiling water and placed for 3 seconds on the skin. The shell root of A. eburnea an Iranian medicinal herb is investigated on its wound healing activity in comparison with silver sulfadiazine ointment as the standard treatment for burn wound in rats. Results:Our results demonstrated that A. eburnea can be an effective treatment for third-degree burns. Advanced clinical and pharmaceutical studies are recommended to the production of novel natural drugs for burn wound treatment. Conclusion:A. eburnea can be an effective treatment for third-degree burns. Advanced clinical and pharmaceutical studies are recommended to the production of novel natural drugs for burn wound treatment.

show abstract

“…[2] However, the process of wound healing may be hindered or delayed due to high free radicals generation with proven CONTACT Sunday O. Oyedemi Sunday@mut.ac.za; sillvanusdemi@gmail.com detrimental effects to wound-surrounding cells or by the invasion of multidrug-resistant bacteria resulting in chronic wounds. [3,4] This type of wound affects a large number of patients and at the same time reduces their quality of life. The current estimate shows that about 6 million people are suffering from chronic wounds worldwide.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and ciprofloxacin modulating activity of Ptaeroxylon obliquum (Thunb.) Radlk leaf used by the Xhosa people of South Africa for the treatment of wound infections

Oyedemi

Falowo

et al. 2016

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

The present work investigated the antibacterial activity of Ptaeroxylon obliquum leaves (POL) extracts in the presence or absence of ciprofloxacin by the broth microdilution method and timeÀkill assay against bacterial strains associated with wound infections. Free-radicalÀscavenging activity (FRSA) was determined using the stable 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) bioassay method. The chemical composition of the most active antioxidant extract was analysed using a gas chromatograph interfaced with a mass spectrometer (GC-MS). All POL extracts showed good antibacterial activity against the bacterial strains, with a minimum inhibitory concentration (MIC) ranging from 4 to 128 mg/mL. The exposure of bacterial strains to POL extracts resulted in 2À64-fold reductions in the MIC of ciprofloxacin. Correspondingly, the timeÀkill curves showed that combined POL extracts and ciprofloxacin treatment inhibited bacterial growth below the lowest detectable limit after 24 h of incubation. Furthermore, the ethanol extract from P. obliquum (POE) had the highest total flavonoids content (TFC: 62.7 mg/quercetin equivalent/g), while the methanol extract of P. obliquum (POM) had the best total phenolic content (TPC: 275 mg/quercetin equivalent/g) and DPPH Ã -scavenging activity having 50% inhibitory concentration (IC 50 ) of 0.125 mg/mL. The chemical composition indicated the presence of aromatic and aliphatic compounds that are known to have a wide biological effect. The findings from this study suggest that POL extracts could be a source of pharmaceutical agents for treatment of skin diseases, wound infections and as putative candidates to modulate the multidrug resistance mechanism. KEYWORDSAntibacterial activity; modulation of resistance; Ptaeroxylon obliquum; timeÀkill kinetics; wound infection Abbreviations CFU colony-forming unit DPPH 2,2-diphenyl-2-picrylhydrazyl hydrate DMSO dimethyl suphuroxide FCR FolinÀCiocalteu reagent FRSA free-radicalÀscavenging activity GAE gallic acid equivalents GC-MS gas chromatographyÀmass spectrometry IC inhibitory concentration MHB MuellerÀHinton broth MIC minimum inhibitory concentration MTT 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide MW molecular weight POA Ptaeroxylum obliquum acetone POC Ptaeroxylum obliquum chloroform POL Ptaeroxylum obliquum leaf POM Ptaeroxylum obliquum methanol ROS reactive oxygen species SIC sub-inhibitory concentration TFC total flavonoids content TPC total phenolic content

show abstract

In vitro tests and ethnopharmacological investigations: Wound healing as an example

Cited by 286 publications

References 21 publications

Phytochemical Evaluation of Polyherbal Formulation of Clinacanthus nutans and Elephantopus scaber to Identify Flavonoids

Phytochemical Evaluation of Polyherbal Formulation of Clinacanthus nutans and Elephantopus scaber to Identify Flavonoids

Effect of Amygdalus eburnea on third degree burns in rats and comparison with silver sulfadiazine ointment

Antibacterial and ciprofloxacin modulating activity of Ptaeroxylon obliquum (Thunb.) Radlk leaf used by the Xhosa people of South Africa for the treatment of wound infections

Contact Info

Product

Resources

About