In vivo action of phosphatidylserine, amitryptiline and stress on the binding of [3H]imipramine to membranes of the rat cerebral cortex

Stockert, Marta; Buscaglia, Virginia Luisa; Robertis, E. De

doi:10.1016/0014-2999(89)90648-1

Cited by 12 publications

(2 citation statements)

References 15 publications

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“…Several lines of evidence reveal an important role for omega-3 fatty acids in mental health . Omega-3 fatty acids are important for neuronal and REVIEW brain development, function, and health (125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135)(136)(137)(138), but see Simmer (139), and are only available from dietary intake such as fish. Lower levels of fish consumption and omega-3 fatty acids have been linked to increased rates of depression and possibly suicide .…”

Section: Diet and Mental Healthmentioning

confidence: 99%

Diet and mental health in the Arctic: is diet an important risk factor for mental health in circumpolar peoples? - a review

McGrath-Hanna¹,

Greene

Tavernier

et al. 2003

International Journal of Circumpolar Health

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Background. The people living in Arctic and Subarctic environments have adapted to cold temperatures, short growing seasons, and low precipitation, but their traditional ways are now changing due to increased contact with Western society. The rapid alteration of circumpolar cultures has led to generational changes in diet from traditional foods to the processed groceries common in modern stores. Objectives. Develop a link between changing traditional diets and mental health that may have substantial consequences for circumpolar peoples. Methods. Review of English language literature pertaining to the northern circumpolar environments of the world that consist of the Arctic and Subarctic areas. Electronic resources such as ISI Web of Science and PubMed were utilized, using keywords such as arctic, circumpolar, diet, omega-3 fatty acids, mental health, seasonal affective disorder, and suicide. In addition, we used the cited references of obtained articles and the extensive University of Alaska Fairbanks library collections to identify additional publications that were not available from the electronic resources. The years covered were not restricted to any particular period, although 83% of the sources were published in the last 16 years. Conclusion. The change in traditional diets has already led to increased health problems, such as obesity, cardiovascular disease, and diabetes, while the mental health of circumpolar peoples has also declined substantially during the same time period. The decline in mental health is characterized by increased rates of depression, seasonal affective disorder, anxiety, and suicide, that now often occur at higher rates than in lower-latitude populations. Studies in non-circumpolar peoples have shown that diet can have profound effects on neuronal and brain development, function, and health. Therefore, we hypothesize that diet is an important risk factor for mental health in circumpolar peoples.

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Section: Diet and Mental Healthmentioning

confidence: 99%

Diet and mental health in the Arctic: is diet an important risk factor for mental health in circumpolar peoples? - a review

McGrath-Hanna¹,

Greene

Tavernier

et al. 2003

International Journal of Circumpolar Health

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“…When it is administered in vivo, phosphatidylserine also displays a broad spectrum of acute and chronic pharamacological actions (Bruni et al, 1976(Bruni et al, , 1985(Bruni et al, , 1986Loeb et al, 1988;Stockert et al, 1989). Some of these effects, such as the enhancement of acetylcholine output from the cerebral cortex (Casamenti et al, 1979), the reversion of the scopolamineinduced amnesia , and the antagonism of scopolamine effects of EEG activity (Aporti et al, 1982) are related to the cholinergic neurotransmission and could be caused by changes in the regulation of mAChR.…”

Section: Introductionmentioning

confidence: 99%

Modulatory effects of phosphatidylserine on the binding of muscarinic cholinergic receptor ligands

Raskovsky

Rivas

Bernik

et al. 1990

Molecular and Chemical Neuropathology

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The modulation of the binding of muscarinic cholinergic receptor ligands by phosphatidylserine purified from bovine cerebral cortex (BC-PS) was examined in vitro and in vivo. The enrichment of bovine cerebral cortical synaptosomal membranes with BC-PS, using a fusion technique, produced a concentration-dependent decrease in the affinity (increase in Kd) of [3H]quinuclidinyl benzylate (3H-QNB) specific binding to muscarinic acetylcholine receptors (mAChR), without changes in their maximal number (Bmax). Similar results were observed when [3H]oxotremorine (3H-OXO) was used to label a high affinity subpopulation of mAChR. On the other hand, preincubation of BC-PS liposomes with synaptosomal membranes in a nonoptimum fusion condition (at pH 7.4) did not alter the binding properties of both radioligands. Fusion experiments using a pure phosphatidylserine preparation from spinal cord revealed a similar decrement in the affinity of 3H-QNB specific binding. Five day's intraperitoneal (i.p.) administration of 15 mg/kg of BC-PS liposomes in rats increased the maximal number of cerebral cortical binding sites for 3H-OXO. Scatchard analysis revealed no changes in the apparent dissociation constant. This modification is selective in relation to the neural structure studied. Thus, BC-PS treatment did not modify 3H-OXO binding in the hippocampal formation and cerebellum. In contrast, parallel experiments using the muscarinic antagonist 3H-QNB showed no alteration in the binding properties of mAChR. Five day's i.p. administration of 15 mg/kg/d of phosphatidylcholine from bovine cerebral cortex (BC-PC) liposomes produced quite similar results to those obtained with BC-PS. These results indicate that mAChR are under the modulatory action of phosphatidylserine (PS) and phosphatidylcholine (PC), and suggest that this endogenous phospholipids may play a regulatory role on the mAChR. The possible implications of these findings on the effects of PC or PS treatment in neurological disorders involving a decrease in central cholinergic functions are discussed.

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Interactions of Phospholipids and Free Fatty Acids with Antidepressant Recognition Binding Sites in Rat Brain

Stockert

Zieher

Medina

1992

Neurobiology of Essential Fatty Acids

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In vivo action of phosphatidylserine, amitryptiline and stress on the binding of [3H]imipramine to membranes of the rat cerebral cortex

Cited by 12 publications

References 15 publications

Diet and mental health in the Arctic: is diet an important risk factor for mental health in circumpolar peoples? - a review

Diet and mental health in the Arctic: is diet an important risk factor for mental health in circumpolar peoples? - a review

Modulatory effects of phosphatidylserine on the binding of muscarinic cholinergic receptor ligands

Interactions of Phospholipids and Free Fatty Acids with Antidepressant Recognition Binding Sites in Rat Brain

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