In vivo anti-lipidemic and antioxidant potential of collagen peptides obtained from great hammerhead shark skin waste

Vijayan, Divya K; Raman, Sreerekha Perumcherry; Dara, Pavan Kumar; Jacob, Rosemol M; Mathew, Suseela; Anandan, R.; Nagarajarao, Ravishankar Chandragiri

doi:10.1007/s13197-021-05118-0

Cited by 7 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior investigations also reported that CPS could lower plasma and hepatic lipid concentrations by suppressing the hepatic protein expression for fatty acid cholesterol synthesis, including sterol regulatory element-binding protein-1, sterol regulatory element-binding protein-2, fatty acid synthase, acetyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase (54)(55)(56) . Recently, animal research by Vijayan et al (57) showed that fish-derived collagen peptide has anti-lipidaemic properties that are mediated by a down-regulation of 3-hydroxy-3-methylglutaryl-CoA reductase expression and up-regulation Lecithin-cholesterol acyltransferase. On other hand, CPS may enhance lipid breakdown by upregulating gene expression of PPAR-α, carnitine palmitoyltransferase 1 and synthesis of bile acid cytochrome P450 family 7 subfamily A member 1 (54)(55)(56) , which play a role in the process of β-oxidation.…”

Section: Discussionmentioning

confidence: 99%

Effects of collagen peptide supplementation on cardiovascular markers: a systematic review and meta-analysis of randomised, placebo-controlled trials

Jalili

Moradi

et al. 2022

Br J Nutr

View full text Add to dashboard Cite

Previous studies have advocated that collagen peptide supplementation (CPS) can positively affect cardiovascular health. However, the widespread impact of CPS on cardiovascular disease-related markers is not fully resolved. Consequently, the current systematic review and meta-analysis aimed to assess the efficacy of CPS on cardiovascular disease-related markers. A systematic search in the Scopus, PubMed, and ISI Web of Science databases were completed to identify relevant randomized, placebo-controlled trials (RCTs) published up to November 2021. Mean Differences were pooled using a random-effects model, while publication bias, sensitivity analyses, and heterogeneity were assessed using previously validated methods. Twelve RCTs, comprising of a total of eleven measured markers, were selected for the quantitative analysis. Pooled data revealed that CPS significantly decreased fat mass (-1.21 kg; 95% CI: -2.13, -0.29; I2 = 0.0%; p = 0.010), and increased fat-free mass, based on body mass percentage (1.49 %; 95% CI: 0.57, 2.42; I2= 0.0%; p = 0.002). Moreover, collagen peptide supplementation led to a significant decrease in serum low-density lipoprotein (-4.09 mg/dl; 95% CI: -8.13, -0.04; I2 = 93.4%; p = 0.048) and systolic blood pressure (-5.04 mmHg; 95 % CI: -9.22, -0.85; I2 = 98.9%; p = 0.018). Our analysis also indicated that CPS did not affect glycemic markers. Our outcomes indicate that CPS reduces fat mass, low-density lipoprotein, and systolic blood pressure while increasing fat-free mass. Future investigations with longer CPS duration are needed to expand on our results.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of collagen peptide supplementation on cardiovascular markers: a systematic review and meta-analysis of randomised, placebo-controlled trials

Jalili

Moradi

et al. 2022

Br J Nutr

View full text Add to dashboard Cite

show abstract

“…Furthermore, the process further lowered rat plasma cholesterol by decreasing the activity of hepatic HMGCR in Zucker (fa/fa) obese rats [73]. Fish skin collagen peptides also have the ability to enhance cholesterol metabolism, and Sphyrna mokarran skin collagen peptides can alleviate HLP induced by a HFD with alcohol [72].…”

Section: Marine Bioactive Peptidesmentioning

confidence: 99%

“…TetraSOD is a unique marine health and functional ingredient derived from the marine microalgae Tetraselmis chuii strain CCFM03, which has a history of use in food and nutraceutical applications around the world [70] TetraSOD promotes endogenous antioxidant defense mechanisms in the liver and modulates plasma markers of oxidative stress and inflammation, thereby ameliorating these effects associated with metabolic syndrome (MetS) [71]. Collagen from the skin of Sphyrna mokarran downregulates the expression of fatty acid synthase (FAS) and 3-hydroxy-3-methylglutaryl monoacyl-coenzyme A reductase (HMGCR), and upregulates the expression of lecithin-cholesterol acyltransferase (LCAT) in the liver to alleviate cholesterol accumulation [72]. Wergedahl et al [73] used lipid-free enzyme digest (a mixture of small peptides and free amino acids) prepared using enzymatic hydrolysis of Salmo salar, L. with Protamex TM protease as a diet and found that it increased the HDL-C/TC ratio in rat plasma.…”

Section: Marine Bioactive Peptidesmentioning

confidence: 99%

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

Liu,

Chen,

Chen

et al. 2023

Nutrients

View full text Add to dashboard Cite

Hyperlipidemia (HLP) is a metabolic disorder caused by abnormal lipid metabolism. Recently, the prevalence of HLP caused by poor dietary habits in the population has been increasing year by year. In addition, lipid-lowering drugs currently in clinical use have shown significant improvement in blood lipid levels, but are accompanied by certain side effects. However, bioactive marine substances have been shown to possess a variety of physiological activities such as hypoglycemic, antioxidant, antithrombotic and effects on blood pressure. Therefore, the hypolipidemic efficacy of marine bioactive substances with complex and diverse structures has also attracted attention. This paper focuses on the therapeutic role of marine-derived polysaccharides, unsaturated fatty acids, and bioactive peptides in HLP, and briefly discusses the main mechanisms by which these substances exert their hypolipidemic activity in vivo.

show abstract

“…Several marine species such as mussels, fish, and algae are sources of antioxidant peptides produced by enzymatic hydrolysis [104]. Collagen peptides with antioxidant activity have been developed from a variety of fish processing by-products, such as grass carp scales [14], squid (Dosidicus gigas) by-products [105], salmon scales [106], hammerhead shark skin [107], redlip croaker (Pseudosciaena polyactis) scales [50], skipjack tuna (Katsuwonus pelamis) [108], and lamuru (Caranx ignobilis) fishbone [109]. The two most common assays for antioxidant activity of peptides are the scavenging of DPPH radicals and the scavenging of ABTS radicals [72].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Improving the Sustainability of Processing By-Products: Extraction and Recent Biological Activities of Collagen Peptides

Zhao

Song

et al. 2023

Foods

View full text Add to dashboard Cite

Society and consumers are increasingly concerned about food safety and the sustainability of food production systems. A significant amount of by-products and discards are generated during the processing of aquatic animals, which still needs to be fully utilized by the food industry. The management and sustainable use of these resources are essential to avoiding environmental pollution and resource waste. These by-products are rich in biologically active proteins, which can be converted into peptides by enzymatic hydrolysis or fermentation treatment. Therefore, exploring the extraction of collagen peptides from these by-products using an enzymatic hydrolysis technology has attracted a wide range of attention from numerous researchers. Collagen peptides have been found to possess multiple biological activities, including antioxidant, anticancer, antitumor, hypotensive, hypoglycemic, and anti-inflammatory properties. These properties can enhance the physiological functions of organisms and make collagen peptides useful as ingredients in food, pharmaceuticals, or cosmetics. This paper reviews the general methods for extracting collagen peptides from various processing by-products of aquatic animals, including fish skin, scales, bones, and offal. It also summarizes the functional activities of collagen peptides as well as their applications.

show abstract

In vivo anti-lipidemic and antioxidant potential of collagen peptides obtained from great hammerhead shark skin waste

Cited by 7 publications

References 31 publications

Effects of collagen peptide supplementation on cardiovascular markers: a systematic review and meta-analysis of randomised, placebo-controlled trials

Effects of collagen peptide supplementation on cardiovascular markers: a systematic review and meta-analysis of randomised, placebo-controlled trials

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

Improving the Sustainability of Processing By-Products: Extraction and Recent Biological Activities of Collagen Peptides

Contact Info

Product

Resources

About