In Vivo Assessment of a New Method of Pulsatile Perfusion Based on a Centrifugal Pump

Herreros, Jesús; Ubilla, M.; Berjano, Enrique; Vila-Nuñez, Juan E.; Páramo, José A.; Sola, Josu; Mercé, Salvador

doi:10.1111/j.1525-1594.2009.00769.x

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…With regard to blood trauma, the pulsatile perfusion mode of the Rotaflow centrifuge pump (Maquet Cardiopulmonary) did not induce any hemolysis as demonstrated by the equally low free plasma hemoglobin during CPB in both groups. This is in agreement with a recent study showing little blood trauma by the pulsatile flow produced by adding a specific pulsatile component to the existing centrifugal pump (26).…”

Section: Discussionsupporting

confidence: 93%

Clinical Effectiveness of Centrifugal Pump to Produce Pulsatile Flow During Cardiopulmonary Bypass in Patients Undergoing Cardiac Surgery

Oeveren²,

Mungroop³

et al. 2011

Artificial Organs

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Although the centrifugal pump has been widely used as a nonpulsatile pump for cardiopulmonary bypass (CPB), little is known about its performance as a pulsatile pump for CPB, especially on its efficacy in producing hemodynamic energy and its clinical effectiveness. We performed a study to evaluate whether the Rotaflow centrifugal pump produces effective pulsatile flow during CPB and whether the pulsatile flow in this setting is clinically effective in adult patients undergoing cardiac surgery. Thirty-two patients undergoing CPB for elective coronary artery bypass grafting were randomly allocated to a pulsatile perfusion group (n = 16) or a nonpulsatile perfusion group (n = 16). All patients were perfused with the Rotaflow centrifugal pump. In the pulsatile group, the centrifugal pump was adjusted to the pulsatile mode (60 cycles/min) during aortic cross-clamping, whereas in the nonpulsatile group, the pump was kept in its nonpulsatile mode during the same period of time. Compared with the nonpulsatile group, the pulsatile group had a higher pulse pressure (P < 0.01) and a fraction higher energy equivalent pressure (EEP, P = 0.058). The net gain of pulsatile flow, represented by the surplus hemodynamic energy (SHE), was found much higher in the CPB circuit than in patients (P < 0.01). Clinically, there was no difference between the pulsatile and nonpulsatile groups with regard to postoperative acute kidney injury, endothelial activation, or inflammatory response. Postoperative organ function and the duration of hospital stay were similar in the two patient groups. In conclusion, pulsatile CPB with the Rotaflow centrifugal pump is associated with a small gain of EEP and SHE, which does not seem to be clinically effective in adult cardiac surgical patients.

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Section: Discussionsupporting

confidence: 93%

Clinical Effectiveness of Centrifugal Pump to Produce Pulsatile Flow During Cardiopulmonary Bypass in Patients Undergoing Cardiac Surgery

Oeveren²,

Mungroop³

et al. 2011

Artificial Organs

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“…One study modified a centrifugal pump with a membrane that was pressurized pneumatically to generate pulsatile flow 17 . Although this pump showed good in vivo results, 18 pulse pressure was limited to approximately 20 mm Hg, and the SHE was supraphysiologic at all flow rates. Dual‐pump configurations with just one of the pumps in pulsatile mode are limited by theoretical considerations.…”

Section: Discussionmentioning

confidence: 99%

Improving adult pulsatile minimal invasive extracorporeal circulation in a mock circulation

et al. 2022

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Background: Pulsatile extracorporeal circulation (ECC) may improve perfusion of critical organs during cardiac surgery. This study analyzed the influence of the components of a minimal invasive ECC (MiECC) on the transfer of pulsatile energy into the pseudo-patient of a mock circulation.Methods: An aortic model with human-like geometry and compliance was perfused by a diagonal pump. Surplus hemodynamic energy (SHE) was determined from flow and pressure data. Five adult-size oxygenator models and three sizes of cannulas were compared. Pulsatile pump settings were optimized, and parallel dual-pump configurations were evaluated. Results:Oxygenator models showed up to twofold differences in pressure gradients and influenced SHE at flow rates up to 2.0 L min −1 . Adjustments of frequency, systole duration, and rotational speed gain significantly improved SHE compared with empirical settings, with SHE above 21% of mean arterial pressure at flow rates of 1.0 L min −1 to 1.5 L min −1 and SHE above 5% at 3.5 L min −1 . Small diameter cannula (15 Fr) limited SHE compared with larger cannula (21 Fr and 23 Fr). Two diagonal pumps did not provide higher SHE than a single pump, but permitted additional control over pulse pressure and SHE by varying the total fraction of pulsatile flow and the fraction of flow bypassing the oxygenator. Conclusions: Proper selection of components and optimizations of pump settings significantly improved pulse pressure and SHE of pulsatile MiECC.Surplus hemodynamic energy depended on flow rate with a maximum at 1.0 L min −1 -1.5 L min −1 . Pulsatile MiECC may specifically assist organ perfusion during phases of low flow.

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“…Jesús Herreros et al. (19) of the Clínica Universitaria, University of Navarra, Pamplona, Spain assessed platelet dysfunction and damage to organs after extracorporeal circulation using a pump that adds a pulsatile flow (pulsating of an inner membrane pneumatically controlled by an intra‐aortic counterpulsation balloon console) to the continuous flow provided by a centrifugal pump (Bio‐pump). Six pigs were subjected to a partial CPB lasting 180 min.…”

Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2010: A Year in Review

Malchesky¹

2011

Artificial Organs

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In this Editor's Review, articles published in 2010 are organized by category and briefly summarized. As the official journal of The International Federation for Artificial Organs, The International Faculty for Artificial Organs, and the International Society for Rotary Blood Pumps, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level."Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide such meaningful suggestions to the author's work whether eventually accepted or rejected and especially to those whose native tongue is not English. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, Wiley-Blackwell, for their expert attention and support in the production and marketing of Artificial Organs. In this Editor's Review, that historically has been widely received by our readership, we aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ Replacement, Recovery, and Regeneration. We look forward to recording further advances in the coming years.

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In Vivo Assessment of a New Method of Pulsatile Perfusion Based on a Centrifugal Pump

Cited by 6 publications

References 16 publications

Clinical Effectiveness of Centrifugal Pump to Produce Pulsatile Flow During Cardiopulmonary Bypass in Patients Undergoing Cardiac Surgery

Clinical Effectiveness of Centrifugal Pump to Produce Pulsatile Flow During Cardiopulmonary Bypass in Patients Undergoing Cardiac Surgery

Improving adult pulsatile minimal invasive extracorporeal circulation in a mock circulation

Artificial Organs 2010: A Year in Review

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