In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques

Faraj, Achraf Al; Fauvelle, F.; Luciani, Nathalie; Lacroix, Ghislaine; Lévy, Michael; Crémillieux, Yannick; Canet-Soulas, Emmanuelle

doi:10.2147/ijn.s16653

Cited by 61 publications

(39 citation statements)

References 34 publications

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“…In a following study, it was found that purified SWNTs with 2% impurities and functionalized SWNTs with 0.7% impurities did not yield a statistically appreciable signals, thus confirming a threshold value of 10% Fe impurities required for significant MRI contrast. 76 Importantly, this study corroborates that 2% Fe, as impurities, can be tolerated in vivo, as no acute toxicological effect was observed in the liver using high-resolution magic angle spinning and quantitative real-time polymerase chain reaction analysis.…”

supporting

confidence: 77%

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Kotagiri¹,

Kim²

2014

IJN

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Carbon nanotubes (CNTs) have recently been in the limelight for their potential role in disease diagnostics and therapeutics, as well as in tissue engineering. Before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages, and sequestration to the liver and spleen for eventual elimination from the body; along with equally important issues such as aqueous solubility, dispersion, biocompatibility, and biofunctionalization. CNTs have not been shown to be able to evade such biological obstacles, which include their nonspecific attachments to cells and other biological components in the bloodstream, before reaching target tissues and cells in vivo. This will eventually determine their longevity in circulation and clearance rate from the body. This review article discusses the current status, challenges, practical strategies, and implementations of coating CNTs with biocompatible and opsonin-resistant moieties, rendering CNTs transparent to opsonins and deceiving the innate immune response to make believe that the CNTs are not foreign. A holistic approach to the development of such “stealth” CNTs is presented, which encompasses not only several biophysicochemical factors that are not limited to surface treatment of CNTs, but also extraneous biological factors such as the protein corona formation that inevitably controls the in vivo fate of the particles. This review also discusses the present and potential applications, along with the future directions, of CNTs and their hybrid-based nanotheranostic agents for multiplex, multimodal molecular imaging and therapy, as well as in other applications, such as drug delivery and tissue engineering.

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supporting

confidence: 77%

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Kotagiri¹,

Kim²

2014

IJN

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“…New techniques for tissue clearing may allow for a more refined observation of particle distribution in the near future (Susaki and Ueda, 2016). For in vivo imaging of particle distribution magnetic resonance imaging (MRI) may be used (Al Faraj et al, 2011).…”

Section: Testing Methodsmentioning

confidence: 99%

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Dušinská

Tulinská

Yamani

et al. 2017

Food and Chemical Toxicology

118

101

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a b s t r a c tThe unique properties of nanomaterials (NMs) are beneficial in numerous industrial and medical applications. However, they could also induce unintended effects. Thus, a proper strategy for toxicity testing is essential in human hazard and risk assessment. Toxicity can be tested in vivo and in vitro; in compliance with the 3Rs, alternative strategies for in vitro testing should be further developed for NMs. Robust, standardized methods are of great importance in nanotoxicology, with comprehensive material characterization and uptake as an integral part of the testing strategy. Oxidative stress has been shown to be an underlying mechanism of possible toxicity of NMs, causing both immunotoxicity and genotoxicity. For testing NMs in vitro, a battery of tests should be performed on cells of human origin, either cell lines or primary cells, in conditions as close as possible to an in vivo situation. Novel toxicity pathways, particularly epigenetic modification, should be assessed along with conventional toxicity testing methods. However, to initiate epigenetic toxicity screens for NM exposure, there is a need to better understand their adverse effects on the epigenome, to identify robust and reproducible causal links between exposure, epigenetic changes and adverse phenotypic endpoints, and to develop improved assays to monitor epigenetic toxicity.

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“…The "holy grail" in CNTs-mediated targeted cancer phototherapy 36 is to deliver high doses of active bionanomolecules to tumor sites for maximum treatment efficacy while minimizing side effects to normal organs 58 ( Figure 4). …”

Section: In Vivo Photothermal Ablation Of Tumors Mediated By Cntsmentioning

confidence: 99%

Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia

Iancu

Mocan²

2011

IJN

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Carbon nanotubes (CNTs) are emerging versatile tools in nanomedicine applications, particularly in the field of cancer targeting. Due to diverse surface chemistry and unique thermal properties, CNTs can act as strong optical absorbers in near infrared light where biological systems prove to be highly transparent. The process of laser-mediated ablation of cancer cells marked with biofunctionalized CNTs is frequently termed “nanophotothermolysis.” This paper illustrates the potential of engineered CNTs as laser-activated photothermal agents for the selective nanophotothermolysis of cancer cells.

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In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques

Cited by 61 publications

References 34 publications

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia

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