In Vivo Confocal Microscopy of Keratic Precipitates in Fuchs Heterochromic Uveitis Syndrome

Hasler, Simon; Thiel, Michael; Becht, C

doi:10.1055/s-0028-1109312

Cited by 5 publications

(3 citation statements)

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“…The KP observed in FUS has also been studied in prior studies. 6,8,9,11 Labbé et al 9 reported their IVCM findings 9 The KP observed in that study was reported to be in dendritic shape with a small central body and numerous pseudopodia with accompanying smaller sized dendritic and stippled precipitates. No distinction between primary and secondary KP was made in that study.…”

Section: Discussionmentioning

confidence: 99%

“…17 In a series of eight patients with the diagnosis of FUS, Hasler et al 6 demonstrated a lower percentage of hexagonal endothelial cells; in the same study, the decrease in endothelial cell densities of FUS patients was found too small to be significantly different. 6 The current study has the highest number of patients with FUS (n ¼ 36) enrolled for endothelial cell density evaluation. In this regard, the results of our study and those of Brooks et al 17 suggest that chronic low-grade inflammation and KP have detrimental effects on endothelial cell morphology in FUS with currently unknown implications.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10][11] Studies using IVCM have revealed a much more heterogeneity in the morphology of KP than that can be appreciated clinically. 12 The purpose of this study was to evaluate the endothelial cell layer in detail with respect to the microscopic appearance of KP and to identify whether endothelial cell layer damage was present in patients with FUS using IVCM.…”

Section: Introductionmentioning

confidence: 99%

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In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs’ uveitis syndrome

Mocan

Kadayıfçılar

İrkeç

2011

Eye

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Purpose To evaluate the endothelial cell layer in patients with Fuchs' uveitis syndrome (FUS) with respect to the type and distribution of keratic precipitates (KP), endothelial cell morphology, and endothelial cell density (ECD), using in vivo confocal microscopy (IVCM). Methods Forty eyes of 40 patients (mean age of 32.2 ± 12.5 years) with the clinical diagnosis of FUS were evaluated with IVCM (Confoscan 3.0, Vigonza, Italy). KP were classified as type I (small, round), type II (stippled), type III (dendritiform), and type IV (globular). When 41 KP type was present, differentiation between the predominant and less frequent KP was made as 'primary' and 'secondary'. ECD was measured and compared with age-matched 60 control subjects. Endothelial blebs were classified as small (3-10 lm) or large (410 lm). Results In 36 (90.0%) cases with FUS, more than one KP type was observed with IVCM. Type III (dendritiform) KP was the most frequently observed primary KP type (85.0%), followed by type II (stippled) KP (15.0%). Secondary KP included type II (58.3%), type IV (globular) (27.8%), and type III (13.9%). The mean endothelial cell density of eyes with FUS (2588±396 cells/mm 2 ) was significantly lower than that of control subjects (2930 ± 364 cells/mm 2 ) (t-test; Po0.001). Eyes with FUS had lower proportion of hexagonal cells and higher percentage of polymegethism compared with the uninvolved contralateral eyes. Endothelial blebs (21 small, 16 large blebs) were observed in 37 (92.5%) eyes.Conclusions FUS is characterized by dendritiform KP and is associated with decreased ECD and altered endothelial cell morphology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs’ uveitis syndrome

Mocan

Kadayıfçılar

İrkeç

2011

Eye

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Virale anteriore Uveitis

Pleyer¹,

Quentin²

2021

Entzündliche Augenerkrankungen

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Fuchs uveitis

2017

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Fuchs uveitis (FU) is a frequent, chronic course of intraocular inflammation, which is associated with a gradual onset of decreased visual acuity. The clinical manifestation of the triad of heterochromia, cataract and glaucoma varies considerably. This explains the often delayed diagnosis. Although the aetiology and pathogenesis of the changes are still unclear, there is no doubt that infections play a significant role. Intraocular antibodies directed against rubella viruses show a high association with the disease pattern, and their detection can even be used to support the diagnosis. The treatment of FU is limited to symptomatic measures. Corticosteroids are usually only moderately effective and should be used with caution due to adverse effects, with progression of cataract and secondary glaucoma. The prognosis of the disease can be regarded as favourable and depends essentially on the secondary changes.

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In Vivo Confocal Microscopy of Keratic Precipitates in Fuchs Heterochromic Uveitis Syndrome

Abstract: KP in FHUS cause a focal damage of endothelial cells reflected in a decreased percentage of healthy hexagonal cells. The degree of endothelial cell damage seems to be low as it does not lead to a significant reduction in the endothelial cell count.

Cited by 5 publications

References 6 publications

In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs’ uveitis syndrome

In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs’ uveitis syndrome

Virale anteriore Uveitis

Fuchs uveitis

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