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Recently, it was suggested that the use of the Advanced Medical Optics Complete MoisturePlus multipurpose cleaning solution might be a risk factor for contracting Acanthamoeba keratitis, and the manufacturer voluntarily recalled it in May 2007. Polymerase chain reaction amplification and sequencing of a variable part of the 18S rRNA gene allowed for the first time tracking of Advanced Medical Optics Complete MoisturePlus-associated Acanthamoeba keratitis isolate from a patient back to the lens cleaning solution itself.

KP in FHUS cause a focal damage of endothelial cells reflected in a decreased percentage of healthy hexagonal cells. The degree of endothelial cell damage seems to be low as it does not lead to a significant reduction in the endothelial cell count.

Intravitreal injection of bevacizumab is related with the possible development of acute non-granulomatous anterior uveitis, after having excluded infectious or other causes of uveitis unrelated to the bevacizumab injection. In recent clinical trials bevacizumab-induced uveitis has been demonstrated to be a rare event. The pathogenesis remains unclear. One possible explanation is the Fc portion of the antibody, which may offer the possibility of an increased cellular immune response. This case underlines the importance to inform patients about the possibility of such an episode.

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