In vivo cytokine-associated responses to biomaterials

Abstract

Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-α, MCP-1, MIP-1α, IL-2, IL-6, IL-1β, VEGF, IL-4, and IL-10 were measured from exudate samples collected from cages containing specimens of polyethylene (PE), polyurethane (PU), or organo-tin polyvinyl chloride (ot-PVC). Empty cages served as negative controls, and lipopolysaccharide (LPS) served as a positive control. Cytokine, chemokine, and growth factor concentrations decreased from the time of implantation to eight weeks post-implantation, and there was an overall increase in cytokine, chemokine, and growth factor production for material-containing cages compared to empty cages. However, cytokine production was only modestly affected by the different surface chemistries of the three implanted polymeric materials.

Serum profile of pro- and anti-inflammatory cytokines in rats following implantation of low-temperature plasma-modified titanium plates

“…To examine the response of the body after implantation of biomaterials, the in vivo determination of different cytokines has recently been used in several studies [8][9][10][11]. Furthermore, a recent study which found that variations in the genes of cytokines including IL-2 and IL-6 influence the severity of osteolysis in patients with total hip arthroplasty demonstrates the potential relevance of cytokines for implant-associated complications [12].…”

Influence of diabetes mellitus on the mineralization ability of two endodontic materials

“…Depending on the composition of sealers, all materials might induce some signaling pathways stimulating the expression of pro inflammatory cytokines and prostaglandins that are involved in initiation of the inflammatory process and that may contribute to a sequence of healing events. 28,29 Many studies have shown that the inflammatory state produces an unfavorable environment for angiogenesis, cellular proliferation, and wound healing.…”

Tissue integration and inflammatory reaction in full-thickness abdominal wall repair using an innovative composite mesh

“…However, the levels were independent of the chemical composition of the tested materials (polyethylene, organotin impregnated polyvinyl chloride and polyurethane). Most of the cytokines identified were pro-inflammatory/ anti-wound healing, and their concentrations in all of the cases tended to decrease over time [24]. The similar cytokine profiles induced by these materials suggest that similar tissue reactions, such as vascularization and fibrous tissue formation, occur in vivo with these chemically diverse, polymeric biomaterials.…”