In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan

Föger, Florian; Schmitz, Thierry; Bernkop‐Schnürch, Andreas

doi:10.1016/j.biomaterials.2006.03.033

Cited by 114 publications

(53 citation statements)

References 21 publications

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“…The tiny tablets were enterocoated with Eudragit L prior to oral administration to rats. The tablets significantly enhanced the oral bioavailability of the rhodamine-123 owing to the P-gp inhibitory effect of the thiolated chitosan (27). In contrast, we succeeded in designing a novel delivery system which releases nanocapsules containing tacrolimus from swellable microspheres able to cross the intestinal epithelial membrane without modulating the normal activity of the P-gp pump simply by hiding the P-gp substrate within the oil core of the nanocapsules and avoiding any molecular contact between the pump and the drug.…”

Section: Resultsmentioning

confidence: 98%

A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs

et al. 2008

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Section: Resultsmentioning

confidence: 98%

A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs

et al. 2008

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“…By alteration of the surface functionality controlled biochemical interactions with body fluids can be achieved. Thiolated chitosan, a biodegradable conjugate obtained by different chemical coupling approaches, combines a series of interesting functions such as mucoadhesive [109], permeation-enhancing [110], in situ gelling and enzyme inhibition properties [111,112]. This conjugate was further processed into functional nanoscale films/coatings built using a layer-by-layer approach for alternate deposition of oppositely charged polyelectrolytes [113].…”

Section: Next Generation Wound Dressings and Formulations Combining Pmentioning

confidence: 99%

Polymers in Wound Repair

Francesko

Fernandes

Rocasalbas

et al. 2014

Advanced Polymers in Medicine

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Efficient dermal wound care implies providing a healing environment at the site of injury. Current repair techniques, including polymeric dressings, are able to accelerate only the healing of epidermal and partial thickness acute wounds based on maintaining the area moist. However, these are not efficient in treatment of full-thickness and chronic wounds, which lack in inborn regenerative elements and are highly prone to infections. For this reason the research interest is nowadays shifted towards functional biomaterials to tackle severe skin deteriorations by providing a beneficiary for healing pro-active and pathogen-free environment. Recent advances in molecular biology and materials science together with better understanding of wound pathophysiology allowed for designing of new wound care approaches that rely on biochemical stimuli to promote wound closure. Biopolymers that couple intrinsic antimicrobial and wound repair properties with hydrophilicity appear as suitable dressing platforms. These can be further upgraded using various bio-entities (therapeutic molecules, cells) with the ability to address specific targets in the biochemical environment of wounds in order to stimulate the healing process. This chapter summarises the abundant experimental and clinical data on polymers in advanced wound dressings, scaffolds for dermal regeneration and platforms for drug delivery.

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“…Adhesion time of chitosan-4 thiobutylamidine derivative based tablets to intestinal mucosa increased by 140 times in comparison with that of original chitosan (Bernkop-Schnurch et al 2003). Apart from enhanced mucoadhesion, chitosan modified by thiol groups improved the permeation capability and inhibited the intestinal P-gp in comparison with original chitosan (Foger et al 2006).…”

Section: Chitosan Derivativesmentioning

confidence: 79%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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The development of drug delivery systems always goes hand in hand with the advancement of material science. The novel synthetic or natural functional materials provide opportunities to design optimal drug delivery systems. Among these, chitosan and its derivatives exhibit excellent application future because of its prominent characteristics. In this chapter, research progress of chitosan and its derivatives for drug delivery, from structure to properties, from properties to its application were overviewed. The physicochemical properties, biological properties, biodegradability, safety evaluation and structure modification of chitosan were introduced. Furthermore, applications of chitosan and its derivatives in drug delivery including as the carrier of nanoparticles and microparticles, as coating material, as matrix of hydrogels, films and sustained release tablets, as stabilizers, as absorption enhancers, were discussed. Finally, the applications of chitosan and its derivatives in different administration routes, and their advantages for gene, protein and vaccine delivery, were reviewed. The numerous successful studies on exploitation and application of chitosan and its derivatives showed promising application future of these materials in drug delivery.

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In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan

Cited by 114 publications

References 21 publications

A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs

A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs

Polymers in Wound Repair

Drug Delivery Applications of Chitosan and its Derivatives

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