2020
DOI: 10.1002/adhm.202000667
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In Vivo Evaluation of Bioabsorbable Fe‐35Mn‐1Ag: First Reports on In Vivo Hydrogen Gas Evolution in Fe‐Based Implants

Abstract: This work investigates the influence of Ag (1 wt%) on the mechanical properties, in vitro and in vivo corrosion, and biocompatibility of Fe‐35Mn. The microstructure of Fe‐35Mn‐1Ag possesses a uniform dispersion of discrete silver particles. Slight improvements in compressive properties are attributed to enhanced density and low porosity volume. Fe‐35Mn‐1Ag exhibits good in vitro and in vivo corrosion rate of Fe‐35Mn due to an increase in microgalvanic corrosion. Gas pockets, which originate from an inflammator… Show more

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Cited by 29 publications
(64 citation statements)
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References 84 publications
(150 reference statements)
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“…Like FeMn, the FeMnAg alloy also has similar compositional and percentage pore variations, and the MnO phase is similarly present within the microstructure, however the presence of the Ag is likely to be more effective in corrosion acceleration as shown when testing in HBSS+Ca. In this case the Ag phase also acted as a cathode while the FeMn matrix served as the anode, as likewise observed in other Ag-containing Fe alloys [ 25 , 40 , 54 , 55 ]. On the other hand, when testing in HBSS, it is possible that considerable ferrous (Fe 2+ ) and ferric (Fe 3+ ) compounds formed on the surface of FeMnAg after 1 h, as indicated in optical images presented in Part II of this work [ 43 ], and limited the measured corrosion current.…”
Section: Discussionsupporting
confidence: 59%
“…Like FeMn, the FeMnAg alloy also has similar compositional and percentage pore variations, and the MnO phase is similarly present within the microstructure, however the presence of the Ag is likely to be more effective in corrosion acceleration as shown when testing in HBSS+Ca. In this case the Ag phase also acted as a cathode while the FeMn matrix served as the anode, as likewise observed in other Ag-containing Fe alloys [ 25 , 40 , 54 , 55 ]. On the other hand, when testing in HBSS, it is possible that considerable ferrous (Fe 2+ ) and ferric (Fe 3+ ) compounds formed on the surface of FeMnAg after 1 h, as indicated in optical images presented in Part II of this work [ 43 ], and limited the measured corrosion current.…”
Section: Discussionsupporting
confidence: 59%
“…Thus, it is reasonable to speculate that biodegradable Fe-based implants could potentially lead to hypoxemia around the implantation sites, where blood oxygen could be excessively consumed. Moreover, in vivo hydrogen evolution has been reported in Fe–35Mn–1Ag currently [ 60 ]. Based on our findings, it could be possible to trigger hydrogen evolution around the Fe-based implants, as water may start being reduced to hydrogen gas when there is hardly any blood oxygen.…”
Section: Discussionmentioning
confidence: 99%
“…Generally, there are several basic types of alloy additives: Noble metals as a second phase composite, like Pd [ 36 , 126 , 127 ], Cu [ 73 , 128 ], Ag [ 125 , 129 , 130 ] cause local galvanic corrosion, because of their high electrochemical potential. The addition of silicon drew the attention of scientists because devices made of the Fe-Mn-Si alloy have shape memory and a higher corrosion rate [ 54 , 68 , 72 , 83 , 131 , 132 ]. Elements from the second group, Mg and Ca, have strong negative electrochemical potentials (Mg = −2.38 V vs. SHE, Ca = −2.76 V vs. SHE).…”
Section: Iron Materials Modificationsmentioning
confidence: 99%
“…The addition of silicon drew the attention of scientists because devices made of the Fe-Mn-Si alloy have shape memory and a higher corrosion rate [ 54 , 68 , 72 , 83 , 131 , 132 ].…”
Section: Iron Materials Modificationsmentioning
confidence: 99%