In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice

Amat, Nurmuhammat; Upur, Halmurat; Blažeković, Biljana

doi:10.1016/j.jep.2010.07.023

Cited by 123 publications

(79 citation statements)

References 29 publications

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“…These set of changes have also been reported by other researchers following CCl 4 treatment. 13,14 Clear focal degenerative regions consisted of necrotic changes on tubules and vasodilated atrophic glomeruli so called CCl 4 -induced nephrotoxicity as described by several researchers, 4 were also demonstrated in all CCl 4 -dosing groups (Fig. 6B).…”

Section: Histopathological Findingssupporting

confidence: 59%

In vivo Pharmacological Effectiveness of Heat-treated Cucumber (Cucumis sativus L.) Juice against CCI4- induced Detoxification in a Rat Model

Bajpai¹,

Kim²,

Park³

et al. 2017

IJPER

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Background: Detoxification of heavy metals such as carbon tetrachloride (CCl 4 ) poisoning has become a major focus of researchers. Objectives: In this study, heat-treated cucumber juice was assessed for its pharmacological effect on protection of carbon tetrachloride (CCl 4 )-induced acute liver and kidney damages. Methods: Initially, during detoxification of CCl 4 , the rats of all groups except the control group (without treatment) were injected with a single intraperitoneal dose of 2.5 mL CCl 4 /kg with 50% concentration (1:1 ratio; v/v in olive oil). Additionally, CCl 4 -treated rats were also dosed with saline, 10 mg/kg, 100 mg/kg, and 500 mg/kg cucumber juice for 1, 3 and 5 days once in a day after 6 h from CCl 4 administration. Results: As a result, the best concentration of cucumber juice was noted to be 10 mg/kg, which showed remarkable protective effect on body weight (212-217 g), enzymatic activities of aspartate aminotransferase (AST; 53 IU/L), alanine aminotransferase (ALT; 125 IU/L), blood urea nitrogen (BUN; 18.8 mg/dL), and creatinine content (0.65 mg/dL) as compared to control (220-232 g; 477 IU/L; 987 IU/L; 16.8 mg/dL; and 0.95 mg/dL), respectively. Moreover, histology and histomorphometry analysis of liver and kidney led to significant reduction in percentage of hepatopathy and nephropathy parameters such as hepatic (46.90±2.63%) and kidney (39.86±2.01) degenerative regions, number of hepatocytes (638.00±47.25), tubules (327.60±26.67) and glomerulus (29.20±1.36). Conclusion: These findings suggest that heat-treated cucumber juice has a significant pharmacological effect on CCl 4 -induced acute liver and kidney damages in experimental rats.

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Section: Histopathological Findingssupporting

confidence: 59%

In vivo Pharmacological Effectiveness of Heat-treated Cucumber (Cucumis sativus L.) Juice against CCI4- induced Detoxification in a Rat Model

Bajpai¹,

Kim²,

Park³

et al. 2017

IJPER

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show abstract

“…In case of using mice as the experimental animal model the reported carbon tetrachloride doses were much less (0.01, 0.016. 0.02 and 0.03 ml/kg) (Amat et al, 2010;Suzuki et al, 1990;Zhou et al, 2010;Wang et al, 2008).…”

Section: Single Dose Carbon Tetrachloride-induced Liver Toxicitymentioning

confidence: 97%

Screening of some Traditionally Used Plants for Their Hepatoprotective Effect

Alqasoumi¹,

Abdel-Kader²

2012

Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health

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“…Liver damage is indicated by an augmented activity of liver marker enzymes such as glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT) and alkaline phosphatase in the serum. [142] …”

Section: In Vitro Modelsmentioning

confidence: 99%

Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

Bansal¹,

Kumar²,

Malviya³

et al. 2014

Phcog Commn.

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In vivo hepatoprotective activity of the aqueous extract of Artemisia absinthium L. against chemically and immunologically induced liver injuries in mice

Cited by 123 publications

References 29 publications

In vivo Pharmacological Effectiveness of Heat-treated Cucumber (Cucumis sativus L.) Juice against CCI4- induced Detoxification in a Rat Model

In vivo Pharmacological Effectiveness of Heat-treated Cucumber (Cucumis sativus L.) Juice against CCI4- induced Detoxification in a Rat Model

Screening of some Traditionally Used Plants for Their Hepatoprotective Effect

Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

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