In vivo intracardiac optical coherence tomography imaging through percutaneous access: toward image-guided radio-frequency ablation

Wang, Hui; Kang, Wei; Carrigan, Thomas P.; Bishop, Austin; Rosenthal, Noah; Arruda, Maurício; Rollins, Andrew M.

doi:10.1117/1.3656966

Cited by 34 publications

(33 citation statements)

References 7 publications

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“…As expected, the untreated myocardium exhibits significant phase retardance, while the birefringence is clearly abolished in the RF-treated tissue. These results are consistent with our previous experiments[3,7] The single channel images are equivalent to conventional OCT and the birefringence before ablation can be observed as intensity fading. Compared with the single channel images, the combined intensity images show little polarization artifact, and the birefringence is more easily observed in the phase retardation images.…”

supporting

confidence: 93%

“…Direct imaging feedback at the catheter tip may improve RFA procedures by confirming catheter contact, identifying tissue structures, and confirming ablation lesion formation. We have previously demonstrated that catheter-based optical coherence tomography (OCT) has the potential to provide such guidance [3-7] and the loss of birefringence in the heart wall is a strong marker of ablation lesion formation which can be detected by conventional single-channel OCT. By incorporating polarimetry techniques, polarization-sensitive optical coherence tomography (PSOCT) can provide phase retardation images based on tissue birefringence in addition to scattering intensity images [8-14]. Therefore, PSOCT should detect RFA lesion formation more accurately and robustly than conventional OCT alone.…”

mentioning

confidence: 99%

“…An OCT catheter based on our previously described cone-scanning forward-viewing concept [7] was fabricated for the PSOCT system. Fig.…”

mentioning

confidence: 99%

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Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring

Wang

et al. 2014

Opt. Lett.

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An all-fiber optic catheter-based polarization-sensitive optical coherence tomography system is demonstrated. A novel multiplexing method was used to illuminate the sample, splitting the light from a 58.5kHz Fourier-domain mode-locked laser such that two different polarization states, alternated in time, are generated by two semiconductor optical amplifiers. A 2.3mm forward-view cone-scanning catheter probe was designed, fabricated, and used to acquire sample scattering intensity and phase retardation images. The system was first verified with a quarter-wave plate and then by obtaining intensity and phase retardation images of high-birefringence plastic, human skin in vivo, and untreated and thermally ablated porcine myocardium ex vivo. The system can potentially in vivo image of the cardiac wall to aid radio-frequency ablation therapy for cardiac arrhythmias.

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confidence: 93%

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confidence: 99%

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Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring

Wang

et al. 2014

Opt. Lett.

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“…In the future, we will extend our algorithm to analyze in vivo imaging of the myocardium using catheter-based OCT system [43]. It has been previously demonstrated that in vivo imaging of the myocardium is possible with a catheter once it is in contact with the tissue wall, displacing the blood [44].…”

Section: Discussionmentioning

confidence: 99%

Extracting three-dimensional orientation and tractography of myofibers using optical coherence tomography

Gan¹,

Fleming²

2013

Biomed. Opt. Express

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Abnormal changes in orientation of myofibers are associated with various cardiac diseases such as arrhythmia, irregular contraction, and cardiomyopathy. To extract fiber information, we present a method of quantifying fiber orientation and reconstructing three-dimensional tractography of myofibers using optical coherence tomography (OCT). A gradient based algorithm was developed to quantify fiber orientation in three dimensions and particle filtering technique was employed to track myofibers. Prior to image processing, three-dimensional image data set were acquired from all cardiac chambers and ventricular septum of swine hearts using OCT system without optical clearing. The algorithm was validated through rotation test and comparison with manual measurements. The experimental results demonstrate that we are able to visualize threedimensional fiber tractography in myocardium tissues.

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“…Most OCT endoscopes developed so far were designed for imaging at 1300 nm, which provides 2-3 mm imaging depth and 8-30 m axial resolution [1][2][3][4][5]. However, there is an increasing need to develop an ultrahigh-resolution OCT endoscope for resolving fine structures (e.g.…”

Section: Introductionmentioning

confidence: 99%

Diffractive Endoscope for Real-time Ultrahigh-resolution Volumetric OCT Imaging at 800 nm

Zhang

Liu

et al. 2014

Biomedical Optics 2014

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In vivo intracardiac optical coherence tomography imaging through percutaneous access: toward image-guided radio-frequency ablation

Cited by 34 publications

References 7 publications

Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring

Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring

Extracting three-dimensional orientation and tractography of myofibers using optical coherence tomography

Diffractive Endoscope for Real-time Ultrahigh-resolution Volumetric OCT Imaging at 800 nm

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