In vivo lymph node mapping and pattern of metastasis spread in locally advanced mid/low rectal cancer after neoadjuvant chemoradiotherapy

Farinella, Eleonora; Viganò, Luca; Fava, Maria; Mineccia, Michela; Bertolino, Franco; Capussotti, Lorenzo

doi:10.1007/s00384-013-1727-4

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…LNs <5 mm in size are called micro LNs, and they are susceptible to being overlooked during the detection phase. 36 It has been reported that nearly half of resected LNs are micro LNs, and nearly half of metastatic LNs are micro LNs. 15 Therefore, harvesting an adequate number of micro LNs is important for accurate tumor staging.…”

Section: Discussionmentioning

confidence: 99%

Use of Carbon Nanoparticles to Improve the Efficiency of Harvesting Lymph Nodes in Rectal Cancer

Cheng

et al. 2023

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Background: The accurate determination of lymph node status in patients with rectal cancer requires harvesting a certain number of lymph nodes. This study investigated whether using carbon nanoparticles (CNs) could improve the efficiency of harvesting lymph nodes in rectal cancer patients. Materials and Methods: Data from patients with rectal cancer treated with radical resection were collected from Nanfang Hospital between January 2014 and June 2021. Patients in the CN group received a CN suspension 1 day before surgery, which was endoscopically injected around the tumor. A 1:1 case-matched study was performed using the propensity score. The efficiency of harvesting lymph nodes was investigated by comparing the number of total nodes, total time, and percentage of nodes <5 mm in size between the CN and non-CN groups. Results: A total of 768 patients were included, with 246 patients who underwent CN injection and 522 patients who did not. After matching, 246 pairs of patients were analyzed. After matching, the number of total nodes of each sample was significantly higher in the CN group than in the non-CN group (P<0.001). The total time for node detection (P<0.001) was significantly shorter in the CN group. The percentage of nodes <5 mm in size was increased significantly in the CN group (P<0.001). Among patients with clinical staging I/II, the difference in positive LNs was significant (21.79% vs. 11.95%, P=0.029). Conclusions: The application of CNs improved the efficiency of harvesting lymph nodes during rectal cancer surgery.

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Section: Discussionmentioning

confidence: 99%

Use of Carbon Nanoparticles to Improve the Efficiency of Harvesting Lymph Nodes in Rectal Cancer

Cheng

et al. 2023

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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“…In this study, it was found that carbon nanoparticle tracer technology can help solve these problems. It has been report that that CNs in the operation is helpful for detect the sentinel lymph node, because the dyeing time is short, and the lymph node staining of each station is insufficient, so, injecting CNs into tumor area 1 -3 days before operation may help the lymph node at each stage fully stained, and these lymph nodes can be used to clean the lymph nodes at all sites and avoid missing cancerous tissue [26]. For the staining lymph nodes other than the third station, the lymph nodes need not be routinely cleaned, but can be excised and sent to rapid frozen pathological examination [27].…”

Section: Discussionmentioning

confidence: 99%

Carbon Nanoparticles for Identifying Lymph Nodes during Surgery in Colorectal Cancer: A Meta-Analysis

Miao¹,

Shen²,

Li³

et al. 2019

JCT

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Aim: To investigative the efficacy of carbon nanoparticles (CNs) to identify the lymph nodes during radical surgery in colorectal cancer. Method: The MEDLINE, EMBASE and Cochrane Library databases were searched electronically to identify the studies that compared the use of CNs (CN group) with control group in patients undergoing colorectal cancer radical surgery (from January 2009 to November 2018). The primary outcome was the number of retrieved central lymph nodes. Results: This meta-analysis identified 2 randomized controlled trials and 5 non-randomized controlled trials. Compared with the control group, the CN group resulted in an average of 7.16 more lymph nodes removed per patient

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“…The rationale of the technique is based on information provided by anatomical and cadaveric studies describing rectal lymphatic mapping, according to which the lymphatic drainage is directed in a centripetal, caudo‐cranial pathway. Aberrant drainage to pelvic nodes is rare (< 5%), even in case of ultralow rectal cancer . Considering the minimally invasive approach that is used to perform ELRR, and the anatomical relationship between the rectum and mesorectum, NGME is necessarily performed by two sequential phases, ex vivo and in vivo .…”

Section: Discussionmentioning

confidence: 99%

A modified sentinel lymph node technique combined with endoluminal loco‐regional resection for the treatment of rectal tumours: a 14‐year experience

et al. 2017

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In vivo lymph node mapping and pattern of metastasis spread in locally advanced mid/low rectal cancer after neoadjuvant chemoradiotherapy

Cited by 8 publications

References 25 publications

Use of Carbon Nanoparticles to Improve the Efficiency of Harvesting Lymph Nodes in Rectal Cancer

Use of Carbon Nanoparticles to Improve the Efficiency of Harvesting Lymph Nodes in Rectal Cancer

Carbon Nanoparticles for Identifying Lymph Nodes during Surgery in Colorectal Cancer: A Meta-Analysis

A modified sentinel lymph node technique combined with endoluminal loco‐regional resection for the treatment of rectal tumours: a 14‐year experience

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