In vivo microcomputed tomography evaluation of rat alveolar bone and root resorption during orthodontic tooth movement

Ru, Nan; Liu, Sean Shih-Yao; Li, Zhuang; Li, Song; Bai, Yuxing

doi:10.2319/031312-219.1

Cited by 47 publications

(40 citation statements)

References 20 publications

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“…Data were further reconstructed to provide axial cross-section images with SkyScan NRecon software (version 1.4.4; Bruker) and converted into 16-bit bitmapped TIFF images with a resolution of 1024 3 1024 pixels. 20 Tooth movement distance (D i ) (mm) was measured 3 times and averaged at each time point (i 5 0, 7, 14, 21, and 28 days). Tooth movement rate (V i ) was then calculated as V i 5ðD i À D iÀ1 Þ=7 (Fig 1, B).…”

Section: Methodsmentioning

confidence: 99%

BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption

Liu

Bai

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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Section: Methodsmentioning

confidence: 99%

BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption

Liu

Bai

et al. 2016

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Some previous studies on the effect of orthodontic treatment on changes in alveolar bone density have indicated that orthodontic tooth movement can decrease bone density around the teeth, 19,21–23 whereas others have reported the opposite. 21,24,25 Campos et al 26 indicated that bone density around the teeth following orthodontic treatment is similar to that from before treatment.…”

Section: Introductionmentioning

confidence: 95%

“…21,24,25 Campos et al 26 indicated that bone density around the teeth following orthodontic treatment is similar to that from before treatment. Thus, research results regarding the effect of orthodontic treatment on bone density around the teeth have been inconsistent.…”

Section: Introductionmentioning

confidence: 97%

Does Orthodontic Treatment Affect the Alveolar Bone Density?

Huang

Liu

et al. 2016

Medicine

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Few studies involving human participants have been conducted to investigate the effect of orthodontic treatment on alveolar bone density around the teeth. Our previous study revealed that patients who received 6 months of active orthodontic treatment exhibited an ∼24% decrease in alveolar bone density around the teeth. However, after an extensive retention period following orthodontic treatment, whether the bone density around the teeth can recover to its original state from before the treatment remains unclear, thus warranting further investigation.The purpose of this study was to assess the bone density changes around the teeth before, during, and after orthodontic treatment.Dental cone-beam computed tomography (CBCT) was used to measure the changes in bone density around 6 teeth in the anterior maxilla (maxilla central incisors, lateral incisors, and canines) of 8 patients before and after orthodontic treatment. Each patient underwent 3 dental CBCT scans: before treatment (T0); at the end of 7 months of active orthodontic treatment (T1); after several months (20–22 months) of retention (T2). The Friedman test was applied to evaluate the changes in the alveolar bone density around the teeth according to the 3 dental CBCT scans.From T0 to T1, a significant reduction in bone density was observed around the teeth (23.36 ± 10.33%); by contrast, a significant increase was observed from T1 to T2 (31.81 ± 23.80%). From the perspective of the overall orthodontic treatment, comparing the T0 and T2 scans revealed that the bone density around the teeth was relatively constant (a reduction of only 0.75 ± 19.85%). The results of the statistical test also confirmed that the difference in bone density between T0 and T2 was nonsignificant.During orthodontic tooth movement, the alveolar bone density around the teeth was reduced. However, after a period of bone recovery, the reduced bone density recovered to its previous state from before the orthodontic treatment. However, the bone density around ∼10% of the teeth in this region could not recover to 80% of its state from before the orthodontic treatment.

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“…These data could also be utilized for further research in large animal and human models. Although in vivo lCT has been used in the assessment of bone remodeling in animal models [25][26][27], there are no reported studies from indexed literature about the real-time assessment of GBR in osseous defects with regard to volumes and mineral densities of newly formed bone (BVNFB, MDNFB) and remaining b-TCP particles (VRBP, MDRBP).…”

Section: Introductionmentioning

confidence: 99%

Guided bone regeneration in standardized calvarial defects using beta-tricalcium phosphate and collagen membrane: a real-time in vivo micro-computed tomographic experiment in rats

et al. 2015

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Guided bone regeneration (GBR) procedures using graft materials have been used for reconstruction of osseous defects. The aim of the present in vivo micro-computed tomographic (µCT) and histologic study was to assess in real time the bone regeneration at GBR sites in standardized experimental calvarial defects (diameter 3.3 mm) using β-tricalcium phosphate (β-TCP) with and without collagen membrane (CM). A single full-thickness calvarial defect was created on the left parietal bone in young female Wistar albino rats (n = 30) weighing approximately 300 g and aged about 6 weeks. The animals were randomly divided into three groups for treatment, based on calvarial defect filling material: (1) control group (n = 10); (2) β-TCP + CM group (n = 10); (3) β-TCP group (n = 10). Real-time in vivo µCT analyses were performed immediately after surgery and at 2, 4, 6 and 10 weeks to determine the volume and mineral density of the newly formed bone (BVNFB, MDNFB) and remaining β-TCP particles (VRBP, MDRBP). The animals were killed at 10 weeks and calvarial specimens were evaluated histologically. In the control group, MDNFB increased significantly at 6 weeks (0.32 ± 0.002 g/mm(3), P < 0.01) compared to that at baseline. In β-TCP + CM group, BVNFB (1.10 ± 0.12 mm(3), P < 0.01) and MDNFB (0.13 ± 0.02 g/mm(3), P < 0.01) significantly increased at the 4th week than baseline. In the β-TCP group, BVNFB (1.13 ± 0.12 mm(3), P < 0.01) and MDNFB (0.14 ± 0.01 g/mm(3), P < 0.01) significantly increased at 6 weeks compared to that at baseline. Significant reduction in VRBP was neither seen in the β-TCP + CM group nor in the β-TCP group. While in the β-TCP + CM group MDRBP was reduced significantly at 6 weeks (0.44 ± 0.9 g/mm(3), P < 0.01) from baseline (0.98 ± 0.03 g/mm(3)), similar significant reduction in MDRBP from baseline (0.92 ± 0.07 g/mm(3)) was seen only at 10 weeks (0.45 ± 0.06 g/mm(3), P < 0.05) in the β-TCP group. Histologic findings at 10 weeks revealed greater amount of NFB with osteocytes in the matrix, in the β-TCP + CM group than in the β-TCP group. Biomechanical assessment of NFB for hardness (H) and elastic modulus (E) revealed significantly higher values for the β-TCP + CM group (H = 612.6 ± 4.28 Mpa; E = 13.57 ± 0.07 Gpa) when compared to those of the control (H = 192.1 ± 4.93 Mpa; E = 6.76 ± 0.04 Gpa) and the β-TCP groups (H = 241.9 ± 6.29 Mpa; E = 4.34 ± 0.06 Gpa). In conclusion, based on real-time assessment, NFB is formed in calvarial defects as early as 4 weeks following GBR with β-TCP + CM as compared to 6 weeks when β-TCP alone was used.

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In vivo microcomputed tomography evaluation of rat alveolar bone and root resorption during orthodontic tooth movement

Cited by 47 publications

References 20 publications

BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption

BoneCeramic graft regenerates alveolar defects but slows orthodontic tooth movement with less root resorption

Does Orthodontic Treatment Affect the Alveolar Bone Density?

Guided bone regeneration in standardized calvarial defects using beta-tricalcium phosphate and collagen membrane: a real-time in vivo micro-computed tomographic experiment in rats

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