In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans

Bronaugh, Robert L.; Wester, Ronald C.; Bucks, Daniel A. W.; Maibach, Howard I.; Sarason, R. L.

doi:10.1016/0278-6915(90)90111-y

Cited by 100 publications

(34 citation statements)

References 8 publications

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“…The greatest difference between in vivo and in vitro absorption values occurred with safrole, which was the least well absorbed and the most volatile compound. Zhai/Maibach Subsequently, they determined the percutaneous absorption of the fragrance benzyl acetate (octanol-water partition coefficient = 1.96) and five other benzyl derivatives (benzyl alcohol, octanol-water partition coefficient = 0.87; benzyl benzoate, octanol-water partition coefficient = 3.97; benzamide, octanol-water partition coefficient = 0.64; benzoin, octanol-water partition coefficient = 1.35, and benzophenone, octanol-water partition coefficient = 3.18) in vivo in rhesus monkeys and human models [39]. Two occlusion methods (plastic wrap and glass chamber) were employed for 24 h. In general, absorption through occluded skin was high.…”

Section: Animalsmentioning

confidence: 99%

Effects of Skin Occlusion on Percutaneous Absorption: An Overview

Zhai

Maibach²

2001

Skin Pharmacol Physiol

202

101

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Section: Animalsmentioning

confidence: 99%

Effects of Skin Occlusion on Percutaneous Absorption: An Overview

Zhai

Maibach²

2001

Skin Pharmacol Physiol

202

101

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“…Bronaugh et al [30] investigated the effect of occlusion on the percutaneous absorption of 6 additional volatile compounds (benzyl acetate, benzamide, benzoin, benzophenone, benzyl benzoate, and benzyl alcohol) in vivo in rhesus monkeys and humans for 24 h employing 2 occlusion methods, plastic wrap and glass chamber. In general, occlusion enhanced the absorption of these compounds.…”

Section: Resultsmentioning

confidence: 99%

“…However, with regard to the effects of occlusion on the penetration of phenols, no relationship was found between the octanol-water partition coefficient of the penetrant and the extent of its penetration under occlusion [28,29]. After investigating the effect of occlusion on the penetration of volatile compounds in vivo in rhesus monkeys, Bronaugh et al [30] failed to correlate the penetrant’s octanol-water partition coefficients with occlusion-enhanced skin penetration.…”

Section: Discussionmentioning

confidence: 99%

Occlusion Effect on in vivo Percutaneous Penetration of Chemicals in Man and Monkey: Partition Coefficient Effects

Hafeez

Maibach²

2013

Skin Pharmacol Physiol

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Background/Aim: Skin occlusion can increase the hydration of the stratum corneum up to 50%, which can have substantial effects on the percutaneous absorption of penetrants by altering skin barrier physiology. Though occlusion is widely utilized to enhance the penetration of applied drugs in clinical practice, it is not well known for which chemicals occlusion enhances the penetration through skin. In this review, we focus on what effect occlusion has on the percutaneous absorption of compounds of varying lipophilicities/hydrophilicities in vivo in the monkey and man. Methods: Studies and prior reviews of the effects of occlusion on the in vivo percutaneous penetration of penetrants of varying liphophilicities/hydrophilicities were identified in the Medline, Pubmed, Embase and Science Citation Index databases. Results: After examining the research articles generated by the search results, 7 original research studies were obtained that used in vivo occlusion models and provided insight regarding the role of partition coefficients in predicting the effects of occlusion on percutaneous penetration. From these studies, one can conclude the following: (1) occlusion enhances the percutaneous absorption of many but not all compounds, (2) penetration can increase as the amount of time of occlusion increases, (3) occlusion seems to enhance the penetration of very lipophilic compounds more than that of very hydrophilic compounds, but (4) a relationship between a compound’s octanol-water partition coefficient and its occlusion-induced enhancement has not been determined. Conclusion: These in vivo studies reinforce the conclusions drawn from in vitro studies that partition coefficients incompletely predict the effect of occlusion on percutaneous penetration.

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“…In this experiments, we used crude oil because we had have the purpose that this oil will be used in aromatherapy treatment applied via the skin through massage or add to bath water or by inhalation. There is some degree of absorption of the individual components into the blood, which was calculated at between 4 and 25% when applied to the skin of a rhesus monkey or man (23). This would be approximately 8 10 -6 and 1 10 -5 g/mL of an essential oil in carrier oil applied.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ylang-Ylang Essential Oil on the Relaxation of Rat Bladder Muscle in vitro and White Rabbit Bladder in vivo

et al. 2003

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Current and primary treatment modality in overactive bladder includes the administration of anticholinergics. The demand for new agents has been rising since anticholinergics have proven to come with many side effects. This study was designed to investigate the effects of ylang-ylang essential oil (YYEO) on the relaxation of urinary bladder muscle in vitro and in vivo. Effects of YYEO were assessed on resting tension, and electrical field stimulation- and various drug-induced contraction in vitro by checking the isometric tension changes of muscle strips and same procedures were repeated in the presence of methylene blue, Nw-Nitro-L-arginine methyl ester hydrochloride (L-NAME), or N-ethylmaleimide, and in vivo. YYEO decreased significantly the contractility of strips. There was no statistically significant difference between the treated group only with YYEO and the pretreated group with YYEO and methylene blue or L-NAME. When N-ethylmaleimide was employed, there was a statistically significant decrease in the rate of contraction. In vivo studies showed the same results compared with in vitro study. The results of this study indicate that YYEO has a relaxing effect on the bladder, and such mechanism is thought to be brought about by a pathway mediated by c-AMP.

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In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans

Cited by 100 publications

References 8 publications

Effects of Skin Occlusion on Percutaneous Absorption: An Overview

Effects of Skin Occlusion on Percutaneous Absorption: An Overview

Occlusion Effect on in vivo Percutaneous Penetration of Chemicals in Man and Monkey: Partition Coefficient Effects

Effects of Ylang-Ylang Essential Oil on the Relaxation of Rat Bladder Muscle in vitro and White Rabbit Bladder in vivo

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