In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue

Nabavi, Seyed Mohammad; Eslami, Shahram; Moghaddam, Akbar Hajizadeh

doi:10.1016/j.foodchem.2011.11.070

Cited by 223 publications

(137 citation statements)

References 20 publications

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“…Erythrocytes are known as main targets of oxidative stress due to the presenting of membrane polyunsaturated fatty acids the linolenic and arachidonic acids [40]. In this study, lipid oxidation of mice erythrocyte by AAPH (300 mmol) induced peroxy radicals leads to hemolysis.…”

Section: Antihemolytic Activitymentioning

confidence: 83%

Antioxidant Activity Assessment of Tamus Communis L. Roots

Zerargui

Baghiani

Khennouf

et al. 2016

Int J Pharm Pharm Sci

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Objective: The aim of this study was to evaluate the antioxidant activities of Tamus communis L. (T. communis) roots. This plant is used in folk medicine in the treatment of rheumatism, arthritis and lumbago. Methods:The extraction of polyphenols has been followed by the determination of total polyphenols and flavonoids. The methanol extract (MeOHE) was chromatographied on a silica gel column. The column was eluted with chloroform and then with chloroform/methanol mixtures of increasing polarity, 6 main fractions (FI--FVI)) were collected and grouped according to their TLC (Thin layer chromatography). Several methods were used to evaluate the in vitro antioxidant activity such as DPPH (2, 2'-diphenyl-1-picrylhydrazy), bleaching of β-carotene for 24 h, lipid peroxidation and anti-hemolytic activity. An in vivo approach was carried out on mice treated with CE (crud extract) at a dose of 100 mg/Kg/day for 21 consecutive days, and one group was treated with vitamin C (Vit C 50 mg/kg) as a standard drug. To determine the improvement of antioxidant potential, basic biochemical parameters were used in tissue (liver), plasma and whole blood. Results:The results showed that the highest level of polyphenols was recorded in FII (73.143±0.009 mg GA-Eq/g extract (Gallic Acid Equivalent))/g of extract) followed by MeOHE (69.786±0.10 mg GA-Eq/g extract). Total flavonoid contents of extracts/fractions showed that MeOHE contains the highest level. Inhibition of DPPH radical showed that MeOHE (0.1187±0.025 mg/ml) and CE (0.2363±0.019 mg/ml) have the most efficient antioxidant activity. All the extracts were capable of inhibiting the bleaching of β-carotene by scavenging linoleate derived free radicals, and all the studied extracts have a very important antihemolytic activity (p<0.001) and revealed an extension of hemolysis half time from 70.34±2.15 min of CTL (AAPH (2,2-azo-bis (2-amidinopropane) dihydrochloride)) and 207±5.65 min for FI. The in vivo assay was exhibited a significant decrease (54.09%) of the content of malondialdehyde (MDA) in the liver and increased glutathione (GSH) and catalase (47.30% and 46.87% respectively). Conclusion:These findings suggest that the extract obtained from T. communis have active substances contributing to the increase in natural antioxidant potential.

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Section: Antihemolytic Activitymentioning

confidence: 83%

Antioxidant Activity Assessment of Tamus Communis L. Roots

Zerargui

Baghiani

Khennouf

et al. 2016

Int J Pharm Pharm Sci

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“…Catalase activity was evaluated according to the method of Nabavi et al (2012c). Briefly, a reaction mixture (3 mL) containing 50 mM of phosphate buffer (2.5 mL; pH 5.0), 5.9 mM of H 2 O 2 (0.4 mL) and heart homogenate (0.1 mL) was incubated for one min and absorbance of the sample was recorded at 240 nm.…”

Section: Determination Of Catalase Activitymentioning

confidence: 99%

“…In intoxication, fluoride induces skeletal and dental fluorosis which causes damage to major tissues of the body such as the heart tissues (Sinha et al 2008). Fluoride accumulation in soft tissues causes oxidative stress through inhibition of different enzymatic systems and increased generation of free radicals (Nabavi et al 2012c). Fluorideinduced oxidative stress plays an important role in progression of a variety of cardiac disorders such as cardiac failure and ischemia (Sinha et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Also, Nabavi et al (2012c) have reported that fluoride increases oxidative stress through abnormal biochemical parameters in different tissues of rats. The free radical-induced oxidative stress is well known as an important mechanism of fluoride intoxication (Nabavi et al 2012c). …”

Section: Introductionmentioning

confidence: 99%

“…Knowing that reactive oxygen species play a crucial role in fluorideinduced cardiotoxicity and oxidative stress, studies have been carried out on the cardioprotective action of antioxidants against fluoride-induced toxicity in cardiac tissues (Sinha et al 2008). Recent reports have determined the mitigative action of herbal antioxidants in some cardiac failures caused by free radicals and other reactive species (Nabavi et al 2012c). Previously, the authors reported that natural antioxidants mitigated the oxidative injuries of fluoride in the cardiac tissues of rat (Nabavi et al 2012b).…”

Section: Introductionmentioning

confidence: 99%

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Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues

Nabavi

Moghaddam

et al. 2012

An. Acad. Bras. Ciênc.

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This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.

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STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

et al. 2016

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Melanoma or malignant melanocytes appear with the low incidence rate, but very high mortality rate worldwide. Epidemiological studies suggest that polyphenolic compounds contribute for prevention or treatment of several cancers particularly melanoma. Such findings motivate to dig out novel therapeutic strategies against melanoma, including research toward the development of new chemotherapeutic and biologic agents that can target the tumor cells by different mechanisms. Recently, it has been found that signal transducer and activator of transcription 3 (STAT3) is activated in many cancer cases surprisingly. Different evidences supply the aspect that STAT3 activation plays a vital role in the metastasis, including proliferation of cells, survival, invasion, migration, and angiogenesis. This significant feature plays a vital role in various cellular processes, such as cell proliferation and survival. Here, we reviewed the mechanisms of the STAT3 pathway regulation and their role in promoting melanoma. Also, we have evaluated the emerging data on polyphenols (PPs) specifically their contribution in melanoma therapies with an emphasis on their regulatory/inhibitory actions in relation to STAT3 pathway and current progress in the development of phytochemical therapeutic techniques. An understanding of targeting STAT3 by PPs brings an opportunity to melanoma therapy. © 2016 BioFactors, 43(3):347-370, 2017.

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In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue

Cited by 223 publications

References 20 publications

Antioxidant Activity Assessment of Tamus Communis L. Roots

Antioxidant Activity Assessment of Tamus Communis L. Roots

Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues

STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

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