In vivo stimulatory effect of multi-component herbal remedy PADMA 28 on mitogen-induced proliferation of mice splenic lymphocytes and their chemokinetic activity

Skopiński, Piotr; Radomska-Leśniewska, Dorota M.; Sokolnicka, I; Bałan, Barbara J.; Siwicki, Andrzej K.; Skopińska-Różewska, Ewa

doi:10.2478/pjvs-2013-0099

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…It is suggested that the preparation exhibits strong angioprotective, antioxidative, immunostimulating, anti-inflammatory, anti-peroxidative, cytoprotective and anabolic activity. According to the producer, chronic illnesses with inflammatory, atherosclerotic (including pathology of the peripheral and central vascular system) and degenerative background, as well as infectious diseases (in particular chronic, recurring infections of the respiratory tract) constitute the indication to use this supplement [ 35 ].…”

Section: Angiogenesis Regulation By Some Natural Antioxidantsmentioning

confidence: 99%

Angiogenesis modulation by exogenous antioxidants

Radomska-Leśniewska

Bałan

Skopiński

2017

cejoi

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Co-operation of the endogenous and exogenous defense system maintains redox homeostasis and is essential for health. The endogenous defense system includes enzymatic (e.g. superoxide dismutase, catalase) and non-enzymatic, low molecular-weight scavengers (e.g. glutathione, ascorbic acid). Pathogenesis of many serious diseases (e.g. cancer, ischemic heart disease) includes oxidative stress which can disturb angiogenesis, the process of formation of new blood vessels sprouting from the existing one. Antioxidants, through reduction of oxidative stress and influence on neovascularization, may modulate progress and results of therapy in those diseases where such processes play an important role. Herein the impact of exogenous antioxidants on angiogenesis and factors modulating this process is presented. Most synthetic antioxidants whose activity has been described (namely N-acetylcysteine, pentoxifylline, synthetic analogue of curcumin, synthetic analogue of epigallocatechin-3 gallate [EGCG], tripertenoids) exert an inhibitory effect on neovascularization. A similar effect was also exhibited by several natural origin antioxidants (e.g. resveratrol, EGCG), which suggests that their application in therapy might normalize excessive angiogenesis. Some natural origin antioxidants e.g. purple coneflower and preparations consisting of natural antioxidants such as Padma 28 and Immunal forte increase a too low baseline level of angiogenesis and decreases a too high level. These preparations exert a regulatory effect on and may normalize neovascularization. They can be used in the case of diseases associated with too low or too high angiogenesis.

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Section: Angiogenesis Regulation By Some Natural Antioxidantsmentioning

confidence: 99%

Angiogenesis modulation by exogenous antioxidants

Radomska-Leśniewska

Bałan

Skopiński

2017

cejoi

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“…Among many natural substances used for years in the treatment of human diseases PADMA 28, a herbal multi-compound remedy, has the roots in old Tibetan medicine [ 146 ]. It is a medicinal product produced in Switzerland (PADMA AG company).…”

Section: Introductionmentioning

confidence: 99%

“…In experimental groups, the reaction of splenic lymphocytes to PHA and their in vitro chemokinetic action was significantly raised as compared to the controls. This shows that PADMA 28 stimulated cell-mediated immunity in examined animals and might be used as immuno- modulating substance in the wide spectrum of doses [ 146 ]. In the last experiment we checked the influence of PADMA administered in high and low daily doses (5.8 mg or 0.085 mg), on immunological angiogenesis and granulocyte metabolic activity in Balb/c mice.…”

Section: Introductionmentioning

confidence: 99%

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Radomska-Leśniewska¹,

Skopiński²,

Bałan³

et al. 2015

cejoi

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Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results. Antioxidants become more and more frequently used in order to maintain homeostasis of the organism and diminish the risk of disease. Herein, we introduce some antioxidant preparations of natural plant origin (Rhodiola, Aloe vera, Resveratrol, Echinacea, Plumbagin) and antioxidant supplements (Padma 28, Reumaherb, Resvega). Analyses of their angiogenic properties, their multidirectional molecular effect on angiogenesis as well as medical application are within the scope of this review. Most of presented preparations down regulate neovascularization. They can be safely administered to patients with abnormally high angiogenesis. Rhodiola modulates, and Echinacea, Aloe vera and Plumbagin inhibit tumour-related angiogenesis in vitro and in vivo (animal models). Resveratrol and Resvega reduce neovascularization in the eye and may be applicable in eye disorders. Padma 28 preparation exhibits angioregulatory activity, decreasing high angiogenesis of cancer cells and increasing physiological angiogenesis, therefore can be used in therapy of patients with various disturbances of angiogenesis. Antioxidant application in the case of angiogenesis-related diseases should take into consideration angiogenic status of the patient.

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“…Some immunotropic activities of PADMA 28 and beneficial effect of this remedy in experimental models of inflammation and wound healing were reported [17–24]. …”

Section: Introductionmentioning

confidence: 99%

The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice

Radomska-Leśniewska

Skopiński

Niemcewicz

et al. 2013

Mediators of Inflammation

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PADMA 28 is a herbal multicompound remedy that originates from traditional Tibetan medicine and possesses anti-inflammatory, antioxidant, antimicrobial, angioprotecting, and wound healing properties. The aim of the present study was to evaluate the influence of this remedy on immunological angiogenesis and granulocytes metabolic activity in Balb/c mice. Mice were fed daily, for seven days, with 5.8 mg of PADMA (calculated from recommended human daily dose) or 0.085 mg (dose in the range of active doses of other herbal extracts studied by us previously). Results. Highly significant increase of newly formed blood vessels number in ex vivo cutaneous lymphocyte-induced angiogenesis test (LIA) after grafting of Balb/c splenocytes from both dosage groups to F1 hybrids (Balb/c × C3H); increase of blood lymphocytes and granulocytes number only in mice fed with lower dose of remedy; and significant suppression of metabolic activity (chemiluminescence test) of blood granulocytes in mice fed with higher dose of PADMA. Conclusion. PADMA 28 behaves as a good stimulator of physiological angiogenesis, but for this purpose it should be used in substantially lower doses than recommended by producers for avoiding the deterioration of granulocyte function.

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In vivo stimulatory effect of multi-component herbal remedy PADMA 28 on mitogen-induced proliferation of mice splenic lymphocytes and their chemokinetic activity

Cited by 3 publications

References 7 publications

Angiogenesis modulation by exogenous antioxidants

Angiogenesis modulation by exogenous antioxidants

Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice

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