Review paper Angiomodulatory properties of Rhodiola spp. and other natural antioxidants

Abstract

Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results. Antioxidants become more and more frequently used in order to maintain homeostasis of the organism and diminish the risk of disease. Herein, we introduce some antioxidant preparations of natural plant origin (Rhodiola, Aloe vera, Resveratrol, Echinacea, Plumbagin) and antioxidant supplements (Padma 28, Reumaherb, Resvega). Analyses of their angiogenic properties, their multidirectional molecular effect on angiogenesis as well as medical application are within the scope of this review. Most of presented preparations down regulate neovascularization. They can be safely administered to patients with abnormally high angiogenesis. Rhodiola modulates, and Echinacea, Aloe vera and Plumbagin inhibit tumour-related angiogenesis in vitro and in vivo (animal models). Resveratrol and Resvega reduce neovascularization in the eye and may be applicable in eye disorders. Padma 28 preparation exhibits angioregulatory activity, decreasing high angiogenesis of cancer cells and increasing physiological angiogenesis, therefore can be used in therapy of patients with various disturbances of angiogenesis. Antioxidant application in the case of angiogenesis-related diseases should take into consideration angiogenic status of the patient.

Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells

“…Resveratrol-induced autophagy in ARPE-19 cells as shown by increased autolysosome formation and autophagy flux, as well as change in the LC3 and p62 protein levels [13] in our study could be further confirmed by TEM. ARPE-19 cells have also been used to show the anti-inflammatory potential of resveratrol through the decrease of IL-6 and IL-8 expression, as well as to show its anti-oxidative properties by exhibiting a cytoprotective effects against the enhancement of IL-8, MCP-1, and VEGF secretion and anti-angiogenic potential by the inhibition of VEGF-A secretion [21,25]. Our results are in agreement with these findings and expand upon the repertoire of other inflammation-and angiogenesis-related factors attenuated by resveratrol (e.g., DKK-1; HGF; IGFBP-2 and 3; IL-11 and 17A; Pentraxin-3).…”

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

“…In an in vitro studies using co-culturing of mouse endothelial and L-1 sarcoma cells, Rhodiola extracts inhibited proliferation and migration of endothelial cells [84]. Rhodiola extracts and salidroside and rosavin were also shown to inhibit in vivo neovascularization that was induced by the implantation of syngeneic tumor cells [84] or human kidney cancer homogenate [114]. …”

Immunmodulatory and Antiproliferative Properties of Rhodiola Species

“…& C. A.Mey. is used in traditional Mongolian medicine, but has been poorly investigated from a phytochemical and pharmacological perspective [6]. In 2010, Panossian et al [7] published a systematic review of clinical trials to evaluate the level of scientific evidence for the efficacy of R. rosea in the treatment of specific conditions (fatigue, depression).…”

“…In addition, the modulatory effects of Rhodiola spp. and other natural antioxidants on angiogenesis have also been recently reviewed [6]. Apart from their adaptogenic properties, it seems that Rhodiola species also have antitumoral and antiproliferative effects, protecting tissues against free radicals and weak and medium-strength mutagens.…”