2021
DOI: 10.1364/boe.412210
|View full text |Cite
|
Sign up to set email alerts
|

In vivo test-driven upgrade of a time domain multi-wavelength optical mammograph

Abstract: A recent upgrade of the time domain multi-wavelength optical mammograph developed by Politecnico di Milano achieved good performance in laboratory tests [Biomed. Opt. Express 9, 755 (2018).10.1364/BOE.9.000755]. However, it proved unsatisfactory when in vivo measurements were finally performed. That led to a further upgrade, including the replacement of the time-to-digital converter with a new model, and the related set-up changes. The new instrument version offers improved laboratory performance (as assessed … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
7
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
4
2

Relationship

3
3

Authors

Journals

citations
Cited by 13 publications
(7 citation statements)
references
References 28 publications
0
7
0
Order By: Relevance
“…In fact, the replacement of the TDC with another model, become available recently on the market and optimized for highthroughput applications (the 8-channel MultiHarp 150 8N, PicoQuant, Germany [12]), has been resolutive [10]. The validation process has then been repeated from step 1.…”
Section: Resultsmentioning
confidence: 99%
“…In fact, the replacement of the TDC with another model, become available recently on the market and optimized for highthroughput applications (the 8-channel MultiHarp 150 8N, PicoQuant, Germany [12]), has been resolutive [10]. The validation process has then been repeated from step 1.…”
Section: Resultsmentioning
confidence: 99%
“…Clinical trials should be preceded by propaedeutic in vivo tests. In light of this good practice, we recently performed laboratory measurements on 3 healthy women, that highlighted the importance of preparatory in vivo tests to comply with a clinical environment [5]. The results obtained for the 3 sessions dedicated to healthy volunteer #1 are depicted in Table 1 We can observe that CV values over the three sessions never exceed 6% for any constituents of interest, implying an adequate level of reproducibility for our purposes.…”
Section: In Vivo Rehearsalsmentioning
confidence: 94%
“…Light is collected on the opposite surface by an 8-SiPM (Silicon PhotoMultipliers) detector and, after amplification, the signal is processed by a Time-to-Digital Converter (MultiHarp 150 8N, PicoQuant, Germany). Finally, data are acquired by a PC [5].…”
Section: Instrumentmentioning
confidence: 99%
See 1 more Smart Citation
“… [5] , [6] and tissue oxygenation [7] , [8] . Moreover, research has advanced to the point of designing and testing clinical prototypes [9] , [10] , [11] , [12] , [13] , [14] . In this way, the development of devices intended for clinical applications, such as early detection, diagnosis, or measurements of response to therapy, is one of the main research goals in Biomedical Optics.…”
Section: Introductionmentioning
confidence: 99%