In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

Abstract

An agent for actinide sequestration with fast uranium uptake kinetics and efficient in vivo uranium removal using a nanoscale metal-organic framework (nano-MOF) is proposed. UiO-66 nanoparticles post-synthetically functionalized with carboxyl groups, UiO-66-(COOH) 4 -180, exhibit the fastest uranium uptake kinetics reported with more than 65 % of uranyl in fetal bovine serum (FBS) removed within 5 min. Moreover, the in vivo bio-distribution studies show that the material partially accumulates in kidneys and femurs where uranium mainly deposits facilitating the in vivo sequestration of uranium. The results of the in vivo uranium decorporation assays with mice show that UiO-66-(COOH) 4 -180 could successfully reduce the amounts of uranyl deposited in kidneys and femurs by up to 55.4 % and 36.5 %, respectively, and is significantly more efficient than the commercial actinide decorporation agent, ZnNa 3 -DTPA.

Rationally Tailoring Pore and Surface Properties of Metal–Organic Frameworks for Boosting Adsorption of Dy3+

“…Metal–organic frameworks (MOFs), connected by inorganic clusters and organic ligands, exhibit the advantage of adjustable pore structure and chemical property. In the past two decades, MOFs exhibited large potential in many fields, such as adsorption, separation, and catalysis. − In particular, water-stable MOFs with rich active sites have been widely used for water-phase adsorption and separation of metal ions. − However, to the best of our knowledge, the works on Dy 3+ adsorption in MOFs are rarely reported to date. Micropore adsorption is considered an effective mode for metal ions, where adjacent active groups are closer, which is beneficial for the synergic effect.…”

The confinement effect of layered double hydroxides on intercalated pyromellitic acidic anions and highly selective uranium extraction from simulated seawater

“…UO 2 2+ is classified as a hard Lewis acid, which has strong affinity to hard Lewis bases such as oxygen. Adsorbents functionalized with O-containing carboxylic, phosphonic, and sulfonic groups, such as UIO-66-(COOH) 4 -180, 42 Zn–Al–Ti LMO@PAs 43 and PyB–SO 3 H, 44 have been developed to trap U( vi ) from various aqueous solutions. The number of coordination sites per unit may influence the uranium extraction performance.…”

Synthesis of core–shell magnetic metal organic framework composite for the efficient removal of uranium(vi)

“…With chemical toxicity and radiotoxicity, uranium is the main pollutant in radioactive wastewater, and once it enters the natural environment, it will seriously threaten the ecosystem and human health. [1][2][3][4][5] Consequently, it is of great significance to explore efficient materials and methods for extracting uranium from radioactive wastewater. Various water treatment techniques, such as chemical precipitation, solid-phase extraction, membrane separation and photocatalysis, are known, but most of the available techniques exhibit the economic and technical disadvantages of high cost, high sensitivity to operational conditions, or generation of sludge.…”