In VivoLactate Editing with Simultaneous Detection of Choline, Creatine, NAA, and Lipid Singlets at 1.5 T Using PRESS Excitation with Applications to the Study of Brain and Head and Neck Tumors

Star‐Lack, Josh; Spielman, Daniel; Adalsteinsson, Elfar; Kurhanewicz, John; Terris, David J.; Vigneron, Daniel B.

doi:10.1006/jmre.1998.1458

Cited by 101 publications

(99 citation statements)

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“…A lactate-editing MRS scheme was used to provide the detection of lactate independent from lipid signals in addition to NAA, choline, and creatine. 25 The MR images and raw MRS data were transferred off-line to an UltraSparc workstation (Sun Microsystems) for analysis with the use of custom software developed at our institution for 3D MRS processing. Spectral processing included 4D Fourier transformations, automatic frequency and phase adjustments, baseline fitting, and peak integration for the choline, creatine, N-acetylaspartate (NAA), lipid, and lactate resonances.…”

Section: Methodsmentioning

confidence: 99%

The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates

Bartha¹,

Yap²,

Miller³

et al. 2007

American Journal of Neuroradiology

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Section: Methodsmentioning

confidence: 99%

The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates

Bartha¹,

Yap²,

Miller³

et al. 2007

American Journal of Neuroradiology

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“…54 In two groups of healthy volunteers, we measured the lactate response to visual stimulation using the new J-editing sequence (N = 5) and the long TE PRESS sequence used for this study of PD patients (N = 6). The results of the two acquisition methods were very similar, except that larger effect sizes for the lactate increase during visual stimulation were observed with the J-editing sequence.…”

Section: Limitations and Validationmentioning

confidence: 99%

Elevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS study

et al. 2008

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Converging evidence suggests that patients with panic disorder have a metabolic disturbance that may influence the regulation of arousal systems and confer vulnerability to 'spontaneous' panic attacks. The consistent finding of elevated brain lactate responses to various metabolic challenges in panic disorder appears to support this model, although the mechanism of this effect is not understood. Several mechanisms have been proposed to account for elevated brain lactate responses in panic disorder, including (1) brain hypoxia due to excessive cerebral vasoconstriction, and (2) a metabolic disturbance affecting lactate metabolism. Recent studies have shown that neural activation (for example, sensory stimulation) causes local lactate accumulation in the presence of increased oxygen availability. The current study used proton magnetic resonance spectroscopic measures of visual cortex lactate changes during visual stimulation in 15 untreated patients with panic disorder and 15 matched volunteers to critically test these two proposed mechanisms of elevated brain lactate responses in panic disorder. Visual cortex lactate/N-acetylaspartate increased during visual stimulation in both groups. The increase was significantly greater in the panic patients than in the comparison group. There were no group differences in end-tidal pCO 2 . The finding that visual stimulation leads to significantly greater visual cortex lactate responses in panic patients is not predicted by the hypoxia model. These results suggest that a metabolic disturbance affecting the production or clearance of lactate is the cause of the elevated brain lactate responses consistently observed in panic disorder and provide further support for metabolic models of vulnerability to this illness.

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“…In contrast, 1 H MRS can detect much smaller tumors (1-2 cm 3 at 1.5 T) with the same signal-to-noise ratio as 31 P MRS at the same acquisition time (25). Proton MRS has been demonstrated to be useful in differentiating between cancer, necrosis, and normal tissue of various organs such as brain (26)(27)(28), prostate (29), neck (28), breast (30,31), kidney (32) and liver (33).…”

Section: Introductionmentioning

confidence: 99%

In Vivo Monitoring Response to Chemotherapy of Human Diffuse Large B-Cell Lymphoma Xenografts in SCID Mice by 1H and 31P MRS

Huang¹,

Nelson²,

Pickup³

et al. 2007

Academic Radiology

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Rationale and Objectives-A reliable non-invasive method for in vivo detection of early therapeutic response of non-Hodgkin's lymphoma (NHL) patients would be of great clinical value. This study evaluates the feasibility of 1 H and 31 P magnetic resonance spectroscopy (MRS) for in vivo detection of response to combination chemotherapy of human diffuse large B-cell lymphoma (DLCL2) xenografts in SCID mice.Materials and Methods. C-ombination chemotherapy with Cyclophosphamide, Hydroxydoxorubicin, Oncovin, Prednisone, and Bryostatin 1 (CHOPB) was administered to tumorbearing SCID mice weekly for up to four cycles. Spectroscopic studies were performed before the initiation of treatment and after each cycle of the CHOPB. Proton MRS for detection of lactate and total choline was performed using a selective multiple-quantum-coherence-transfer (Sel-MQC) and a spin-echo-enhanced Sel-MQC (SEE-Sel-MQC) pulse sequence, respectively. Phosphorus-31 MRS utilizing a non-localized single-pulse sequence without proton decoupling was performed on these animals.Results-Significant decreases in lactate and total choline were detected in the DLCL2 tumors after one cycle of CHOPB chemotherapy. The ratio of phosphomonoesters to β-nucleoside triphosphate (PME/βNTP, measured by 31 P MRS) significantly decreased in the CHOPB treated tumors after two cycles of CHOPB. The control tumors did not exhibit any significant changes in either of these metabolites.Conclusions-This study demonstrates that 1 H MRS and 31 P MRS can detect in vivo therapeutic response of NHL tumors and that lactate and choline offer a number of advantages over PMEs as markers of early therapeutic response.

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In VivoLactate Editing with Simultaneous Detection of Choline, Creatine, NAA, and Lipid Singlets at 1.5 T Using PRESS Excitation with Applications to the Study of Brain and Head and Neck Tumors

Cited by 101 publications

References 50 publications

The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates

The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates

Elevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS study

In Vivo Monitoring Response to Chemotherapy of Human Diffuse Large B-Cell Lymphoma Xenografts in SCID Mice by 1H and 31P MRS

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