Inadequate Diet is Associated with Acquiring<i>Mycobacterium tuberculosis</i>Infection in an Inuit Community: A Case-Control Study

Fox, Gregory J.; Lee, Robyn S; Lucas, Michel; Khan, Faiz Ahmad; Proulx, Jean-François; Hornby, Karen; Jung, Shelley; Benedetti, Andrea; Behr, Marcel A.; Menzies, Dick

doi:10.1513/annalsats.201503-156oc

Cited by 22 publications

(28 citation statements)

References 18 publications

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“…The multivariate models in this report do not adjust for measures of nutritional inadequacy; a detailed evaluation of nutritional factors is reported elsewhere. 20 The study was approved by the Nunavik Nutrition and Health Committee, the mayor and municipal council of the village and the Institutional Review Board of McGill University.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…17,20 The evaluation of these 695 people has been previously reported in detail. 17,20 It included tuberculin skin testing (TST) performed and interpreted per the Canadian Tuberculosis Standards, 21 in those who did not have a documented prior positive TST result. All those in whom TB disease was suspected on the basis of radiographic or clinical findings submitted 3 spontaneous or induced sputum samples, which were sent for acid-fast microscopic examination, liquid culture and nucleic acid amplification testing.…”

Section: Methodsmentioning

confidence: 99%

“…Trained study staff administered questionnaires assessing housing, nutrition, socioeconomic and lifestyle factors. 20 Parents or guardians provided responses for children aged up to 12 years. Informed consent was obtained from each participant or the parent/guardian before the questionnaires were administered.…”

Section: Sources Of Datamentioning

confidence: 99%

“…17 A detailed evaluation of dietary and lifestyle factors identified inadequate intake of fruits, vegetables and carbohydrates as nutritional factors associated with infection. 20 These variables were not associated with disease. This paper focuses on the relation between TB outcomes and housing characteristics.…”

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confidence: 92%

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Housing and tuberculosis in an Inuit village in northern Quebec: a case-control study

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 92%

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Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients

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Increased vegetable and fruit intake is associated with reduced failure rate of tuberculosis treatment: a hospital-based cohort study in China

Wang

Zhao

et al. 2020

Br J Nutr

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Increased intake of vegetables and fruits has been associated with reduced risk of tuberculosis infection. Vegetables and fruits exert immunoregulatory effects and may be beneficial for treating pulmonary tuberculosis. However, it is not clear whether vegetables and fruits have an adjuvant treatment effect on tuberculosis. Furthermore, limited research has been conducted on the effects of colour categories and specific types of vegetables on tuberculosis treatment outcome. Between 2009 and 2013, a hospital-based cohort study was conducted in Linyi, Shandong Province, China. Treatment outcome was ascertained by sputum smear and chest computerized tomography, and dietary intake was assessed by a semi-quantitative food frequency questionnaire. The dietary questionnaire was conducted at the end of month two of treatment initiation. Participants recalled their dietary intake of the previous two months. A total of 2,309 patients were enrolled in this study. After 6 months of treatment, 2,099 patients were successfully treated and 210 were uncured. In multivariate models, higher intake of total vegetables and fruits [OR (95% CI): 0.70 (0.49-0.99)], total vegetables [OR (95% CI): 0.68 (0.48-0.97)], dark-coloured vegetables [OR (95% CI): 0.61 (0.43-0.86)], light-coloured vegetables [OR (95% CI): 0.67 (0.48-0.95)] were associated with reduced failure rate of tuberculosis treatment. No association was found between total fruit intake and reduced failure rate of tuberculosis treatment [OR (95% CI): 0.98 (0.70-1.37)]. High intake of total vegetables and fruits, especially vegetables, is associated with lower risk of failure of tuberculosis treatment in pulmonary tuberculosis patients. The results provide important information for dietary guidelines during tuberculosis treatment.

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Inadequate Diet is Associated with AcquiringMycobacterium tuberculosisInfection in an Inuit Community: A Case-Control Study

Abstract: Inadequate nutrition was associated with increased susceptibility to infection, but not active tuberculosis. Interventions addressed at improving nutrition may reduce susceptibility to infection in settings where access to healthy foods is limited.

Cited by 22 publications

References 18 publications

Housing and tuberculosis in an Inuit village in northern Quebec: a case-control study

Housing and tuberculosis in an Inuit village in northern Quebec: a case-control study

Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients

Increased vegetable and fruit intake is associated with reduced failure rate of tuberculosis treatment: a hospital-based cohort study in China

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