Inappropriate secretion of antidiuretic hormone associated with Guillain‐Barré syndrome

Hochman, M. Seth; Kobetz, Steven A.; Handwerker, John V.

doi:10.1002/ana.410110317

Cited by 33 publications

(9 citation statements)

References 5 publications

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“…It is considered that damage of the hypothalamus causes SIADH, even if hypothalamic lesions are not detected (24). SIADH has also been documented in patients with peripheral neuropathies such as Guillain-Barré syndrome (25)(26)(27), acute autonomic and sensory neuropathy (28), and paraneoplastic autonomic and sensorymotor neuropathy (29). In previous reports of neuropathies with SIADH, most patients had severe autonomic dysfunction (28,29).…”

Section: Discussionmentioning

confidence: 98%

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

et al. 2012

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Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein present the case of a patient with NMOSD who also was affected with peripheral neuropathy. A 58-year-old woman developed gait disturbance and sensory impairment in the lower limbs. She exhibited longitudinally extensive transverse myelitis with anti-AQP4 antibodies. Nerve conduction studies showed demyelinating changes. Laboratory findings showed hepatitis-C virus (HCV) infection. Her peripheral neuropathy improved after immunotherapy. There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy.

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Section: Discussionmentioning

confidence: 98%

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

et al. 2012

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“…Salt-wasting without an underlying causative CNS disease has been described as pure renal salt-wasting (RSW) in association with non-neurotropic drug side effects (eg, cisplatin), in older people with various common diseases (eg, hip fracture, pulmonary infections) and other sporadic conditions 3. In Guillain–Barré Syndrome (GBS), however, hyponatraemia has been described mainly as SIAD 4. However, symptoms of hyponatraemia rarely develop in GBS.…”

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confidence: 99%

Renal salt wasting as part of dysautonomia in Guillain-Barre syndrome

Lenhard¹,

Grimm

Ringleb

2010

Journal of Neurology, Neurosurgery & Psychiatry

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Cerebral salt-wasting syndrome and the syndrome of inappropriate antidiuresis (SIAD) are the most important causes of non-iatrogenic hyponatraemia that can significantly complicate various brain diseases. Salt wasting without an underlying CNS disease may have been disregarded so far by clinicians and has been described as renal salt-wasting (RSW) in patients as drug side effect (eg, cisplatin), in older people with various common diseases (eg, hip fracture, pulmonary infections) and other sporadic conditions. In Guillain-Barré Syndrome (GBS), however, hyponatraemia has been described mainly as SIAD. However, symptoms of hyponatraemia rarely develop in GBS. Here, we report on a woman with GBS with dominant symptoms of dysautonomia and moderate severe hyponatraemia. We could identify RSW as part of the autonomic dysfunction that significantly contributed to disease worsening.

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“…Our patient, however, did not require mechanical ventila tion. Hochm an et al [8] reported that factors besides abnormalities of afferent vagal action may produce SIADH in a patient with mild GBS. Our patient present ed only mild symptoms, that is lower limbweakness, while the renin-angiotensin system was probably acti vated by sympathetic overactivity.…”

Section: Discussionmentioning

confidence: 99%

Inappropriate Secretion of Antidiuretic Hormone and Transient Hypertension Associated with Guillain-Barré Syndrome

Kaneko¹,

Shioya²,

Yabuta

1989

Pediatr Neurosurg

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A rare case with Guillain-Barré syndrome complicated by inappropriate secretion of antidiuretic hormone (SIADH) and hypertension was reported. This case showed clinically mild symptoms without respiratory muscle paralysis and had a complete neurological recovery. It should, therefore, be considered that the Guillain-Barré syndrome may cause SIADH and hypertension independent of the severity of the disease.

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Inappropriate secretion of antidiuretic hormone associated with Guillain‐Barré syndrome

Cited by 33 publications

References 5 publications

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity

Renal salt wasting as part of dysautonomia in Guillain-Barre syndrome

Inappropriate Secretion of Antidiuretic Hormone and Transient Hypertension Associated with Guillain-Barré Syndrome

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