The ability to engineer material properties at the nanoscale is a crucial prerequisite for nanotechnology. Hereunder, we suggest and demonstrate a novel approach to realize non-hemispherically shaped nanowire catalysts, subsequently used to grow InP nanowires with a cross section anisotropy ratio of up to 1:1.8. Gold was deposited inside high aspect ratio nanotrenches in a 5 nm thick SiN x selective area mask; inside the growth chamber, upon heating to 455 °C, the thin gold stripes agglomerated, resulting in an ellipsoidal dome (hemiellipsoid). The initial shape of the catalyst was preserved during growth to realize asymmetrically cross-sectioned nanowires. Moreover, the crystalline nature of the nanowire side facets was found to depend on the nano-trench orientation atop the substrate, resulting in hexagonal or octagonal cross-sections when the nano-trenches are aligned or misaligned with the [110] orientation atop a [111]B substrate. These results establish the role of catalyst shape as a unique tool to engineer nanowire growth, potentially allowing further control over its physical properties.For the purpose of controlling and improving semiconducting nanowire (NW) devices for various applications 1-7 , an extensive research effort has been invested in studying NW growth; this was typically achieved by studying the different effects of user controlled parameters: (i) materials -including type and size of NW catalyst, the growth substrates and precursors, and (ii) by altering growth-system parameters, i.e., temperature and precursor flow [8][9][10][11][12][13][14][15][16][17] . In the following report we present a new paradigm, that of catalyst shape engineering, as a useful tool to control NW growth results; in particular, we show that by imposing a non-hemispherical shape to the catalyst-substrate interface, anisotropic cross-sectioned NWs may be grown -NWs with potentially new physical characteristics. Furthermore, we show that the combination of a non-hemispherical catalyst with different crystalline orientations of the long axis results in non-trivial side-faceting of the grown NWs. Nanowire cross section shape and faceting is expected to influence its electrical, mechanical, optical and chemical properties [18][19][20][21][22][23][24] . In particular, Foster et al. have shown that the emission of InGaAs quantum wells embedded inside selective-area-grown anisotropically cross-sectioned GaAs NWs, exhibited linear polarization aligned with the long cross-section axis; basically, when one cross-sectional length-scale is too small to support an optical mode, the spatial degeneracy is lifted and the photoluminescence becomes linearly polarized 22 . This work is an excellent reference for catalyst free growth of anisotropic cross-sectioned NWs, and will be discussed below in further detail. Similar results have been reported by Li et al., in regards to polarisation of laser emission from top-down fabricated GaN NWs 23 . In a different case, Mankin et al. have studied the reactivity of different facets of a VLS ...