Incidence and genetic aspects of patellar luxation in Pomeranian dogs in Thailand

Soontornvipart, Kumpanart; Wangdee, Chalika; Kalpravidh, Marissak; Brahmasa, A.; Sarikaputi, Meena; Temwichitr, J.; Lavrijsen, I.C.M.; Theyse, L. F. H.; Leegwater, P.A.J.; Hazewinkel, H. A. W.

doi:10.1016/j.tvjl.2012.07.027

Cited by 23 publications

(40 citation statements)

References 6 publications

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“…Medial patellar luxation (MPL) is one of the most common musculoskeletal diseases affecting pelvic limbs in dogs, [1][2][3][4] especially in small breeds like Pomeranian, Chihuahua, Yorkshire Terrier, Toy Poodle and Maltese. [5][6][7] The etiology of MPL remains unclear, but in many reports of breed predisposition a hereditable component of the pathogenesis is suspected. [6][7][8][9] Medial patellar luxation as an inherited developmental disease, depending on its severity, can lead to a variable degree of musculoskeletal abnormalities of the pelvic limb.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Radiographic Measurements of the Femur in Yorkshire Terriers with and without Medial Patellar Luxation

Žilinčík

Hluchý

Takáč

et al. 2018

Vet Comp Orthop Traumatol

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Section: Introductionmentioning

confidence: 99%

Comparison of Radiographic Measurements of the Femur in Yorkshire Terriers with and without Medial Patellar Luxation

Žilinčík

Hluchý

Takáč

et al. 2018

Vet Comp Orthop Traumatol

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“…In the non-recurrence group, the dates were record from the surgery date to the end of December, 2015. The recurrence rate was compared between the grade of patellar luxation (1)(2)(3)(4), and between the unilateral and the bilateral patellar luxation.…”

Section: Recurrence Ratementioning

confidence: 99%

“…As well documented, in small animal orthopedics, patellar luxation is one of the most common joint diseases in dogs, particularly small breed dogs [1][2][3][4] . Consequence of this disease being left untreated is that it can cause many complications and disorders such as cranial cruciate rupture [1,5] , cartilage erosion [2,6] , and osteoarthritis [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Düzleşmemiş Femoral Sulkusda Kemik Rekonstruksiyonu Yapılmaksızın Uygulanan Dört Tekniğin Kombine Kullanıldığı Medial Patella Lukzasyon Operasyonu Hakkında Retrospektif Çalışma: 10 Yıllık Periyotta 133 Olgu (2006-2015)

Nganvongpanit¹,

Buddhachat²,

Boonsri³

et al. 2017

Kafkas Univ Vet Fak Derg

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To assess signalment and outcome for dogs surgically treated for non-flattened femoral sulcus medial patellar luxation with combined soft tissue reconstruction techniques, cranial sartorius desmotomy, medial retinacular fascia release, patellar antirotational suture, and fascia lata overlapping, medical records from January 2006 to December 2015 were reviewed. Information obtained from medical records of cases in the study population included breed, age, sex, weight, type of patellar luxation (unilateral or bilateral), grade of patellar luxation, lameness score record, time of last followup, and time of luxation recurrent. The data were analyzed to determine factors influencing outcomes. Twenty-three dogs from 133 presented recurrent patellar luxation. A total of 12 from the 23 recurrent patellar luxation dogs were bilateral (52%) and 11 (48%) were unilateral. The time of recurrence after surgery varied from 1 month to 79 months. From the medical records as on the day of the study, it was found that the longest time that there was no recurrence in dogs was 10 years. It was found that, among the many factors, only grade 4 patellar luxation was a risk factor of considerable recurrence rate (OR=12.44, P=0.02). These results suggest that the combined four soft tissue reconstruction techniques demonstrated excellent outcome in the treatment of medial patellar luxation (with non-flattened femoral sulcus) in small breed dogs. At the same time, it can be stated that bone reconstruction technique is not always necessary. Keywords ÖzetDüzleşmemiş femoral sulkus medial patella lukzasyonu kombine yumuşak doku rekonstrüksiyon teknikleri olan, kranial sartorius desmotomi, medial retinakular fasyanın serbestleştirilmesi, patella antirotasyonal dikiş ve fasia lata üstüste getirme ile tedavi edilen köpeklerin durumlarını ve elde edilen sonuçları değerlendirmek amacıyla, Ocak 2006 ile Aralık 2015 tarihleri arasındaki hasta raporları gözden geçirildi. Çalışmadaki olguların raporlarından elde edilen bilgiler ırk, yaş, cinsiyet, ağırlık, patella lukzasyon tipi (unilateral veya bilateral), patella lukzasyon derecesi, topallık skoru, son takip zamanı ve lukzasyon tekrarlama zamanı bilgilerini içerdi. Sonuçları etkileyen faktörleri belirlemek amacıyla veriler analiz edildi. Toplam 133 köpekten 23'ünde tekrarlayan patella lukzasyonu bulunmaktaydı. Bu olguların 12'si (%52) bilateral ve 11'i (%48) unilateral karakterdeydi. Operasyon sonrası tekrarlama zamanı 1 ay ile 79 ay arasında değişti. Çalışmanın yapıldığı zaman itibariyle tekrarlama görülmeyen en uzun zaman 10 yıl olarak belirlendi. Birçok faktör arasından sadece 4. derece patella lukzasyonu tekrarlama oranı (OR=12.44, P=0.02) için risk faktörü oluşturmaktaydı. Bu sonuçlar kombine olarak dört yumuşak doku rekonstrüksiyon tekniğinin küçük cüsseli köpeklerde medial patella lukzasyon (düzleşmemiş femoral sulkuslu) tedavisinde mükemmel sonuç gösterdiğini belirtmektedir. Ayrıca, kemik rekonstrüksiyon tekniğinin her zaman gerekli olmadığı söylenebilir.

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“…Patellar luxation (PL) is one of the most common joint diseases in small breed dogs [1][2][3] , the prevalence of which has been studied worldwide. In Chiang Mai, Thailand, for example, 128 out of 317 dogs (40.3%) were reported to be affected with PL, predominantly in poodles (34.4%), Pomeranians (28.9%), and Chihuahuas (12.5%).…”

Section: Introductionmentioning

confidence: 99%

“…Originally, clinicians focused on finding an effective surgical technique for treating this condition [5][6][7][8] . So far, targeted gene studies have detected loci on chromosomes 7 and 31 that are involved in PL [2,9,10] . Patellar luxations can be medial or lateral and are graded based on severity [11] .…”

Section: Introductionmentioning

confidence: 99%

Köpeklerde Patellar Luksasyonda Kıkırdak Erozyonunun Prevalansı ve Etkilenmiş Eklemlerdeki Gen Ekspresyonu

Boonsri¹,

Pradit²,

Soontornvipart³

et al. 2016

Kafkas Univ Vet Fak Derg

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The objectives of this study were to assess the prevalence of cartilage erosion in small dogs with patellar luxation (PL), and related osteoarthritis (OA)-related gene expression. In Study 1, 71 dogs were examined to determine risk factors associated with PL, including breed, age, weight, sex, and affected joint. In Study 2, a total of 39 dogs were divided into four groups: normal articular cartilage in the stifle joint (G1; n=5); PL without cartilage erosion (G2; n=11); PL with cartilage erosion (G3; n=14); and OA in the stifle (G4; n=9). Articular cartilage and synovial membranes were collected during surgical operations to correct PL. Real-time PCR was used to quantify the expression levels of 11 OA-related genes, including AGG, COL2A1, HAS-1, with GAPDH used as a reference gene. From Study 1, it was found that the risk factors related with cartilage erosion lesion were age, sex, and PL grade (all variables showed P<0.05). From Study 2, it was demonstrated that PL with or without cartilage erosion expressed pro-inflammatory cytokines and enzymes; some biomolecules were up regulated (IL-1β, MMP-3, AGG, TIMP-1) but some were down regulated (COL2A1, . This expression was the difference between the articular cartilage and the synovial membrane; however, the expression of genes from PL with cartilage erosion was observed to be similar to that of OA. From our results, it can be concluded that PL can develop into secondary OA due to an increase of IL-1β in cartilage and synovial membrane. Keywords: Cartilage erosion, Dog, Gene expression, Patellar luxation Köpeklerde Patellar Luksasyonda Kıkırdak Erozyonunun Prevalansı ve Etkilenmiş Eklemlerdeki Gen Ekspresyonu ÖzetBu çalışmanın amacı patellar luksasyonlu (PL) küçük cüsseli köpeklerde kartilaj erozyonunun prevalansını ve osteoartritis (OA)-alakalı gen ekspresyonunu belirlemektedir. Birinci araştırmada; cins, yaş, cinsiyet ve infekte eklemi içeren PL ile ilgili risk faktörlerini belirlemek amacıyla 71 köpek incelendi. İkinci araştırmada toplam 39 köpek dört gruba ayrıldı; diz ekleminde normal artikular kartilaj (G1; n=5), kartilaj erozyon olmayan PL (G2; n=11), kartilaj erozyonlu PL (G3; n=14) ve dizde OA (G4; n=9). Cerrahi operasyon sırasında PL'u düzeltmek amacıyla artiküler kartilaj ve sinoviyal zarlar alındı. Toplam 11 adet OA ile ilgili genin (AGG, COL2A1,; referans gen olarak GAPDH kullanıldı) ekspresyon düzeylerini belirlemek amacıyla PCR tekniği uygulandı. Birinci araştırmanın sonucunda yaş, cinsiyet ve PL derecesi kartilaj erozyonu ile ilgili risk faktörleri olarak belirlendi (P<0.05). İkinci araştırmada kartilaj erozyonlu veya erozyon bulunmayan PL'lu köpeklerde pro-inflamatuar sitokinleri eksprese ettikleri, bazı biyomoleküllerin ekspresyonunu artırdıkları AGG, bazılarını ise azalttıkları (IL-1β, MMP-3, AGG, TIMP-1) gözlemlendi. Bu ekspresyon artiküler kartilaj ve sinoviyal zar için farklıydı. Ancak kartilaj erozyonlu PL'da genlerin ekspresyonu OA ile benzerlik göstermekteydi. Çalışma bulguları doğrultusunda kıkırdak ve sinoviyal zarlarda artan ...

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Incidence and genetic aspects of patellar luxation in Pomeranian dogs in Thailand

Cited by 23 publications

References 6 publications

Comparison of Radiographic Measurements of the Femur in Yorkshire Terriers with and without Medial Patellar Luxation

Comparison of Radiographic Measurements of the Femur in Yorkshire Terriers with and without Medial Patellar Luxation

Düzleşmemiş Femoral Sulkusda Kemik Rekonstruksiyonu Yapılmaksızın Uygulanan Dört Tekniğin Kombine Kullanıldığı Medial Patella Lukzasyon Operasyonu Hakkında Retrospektif Çalışma: 10 Yıllık Periyotta 133 Olgu (2006-2015)

Köpeklerde Patellar Luksasyonda Kıkırdak Erozyonunun Prevalansı ve Etkilenmiş Eklemlerdeki Gen Ekspresyonu

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