“…About 50-60% of patients admitted to the intensive care unit have vitamin D deficiency (2,4,15,16). This deficiency is presumably caused by decreased intake and absorption, increased losses and decreased production of vitamin D (2,4).…”
Section: Vitamin D Deficiency In the Critically Illmentioning
“…About 50-60% of patients admitted to the intensive care unit have vitamin D deficiency (2,4,15,16). This deficiency is presumably caused by decreased intake and absorption, increased losses and decreased production of vitamin D (2,4).…”
Section: Vitamin D Deficiency In the Critically Illmentioning
“…1 Vitamin D deficiency has been found in many chronic diseases and studies have shown that it can also be associated with illness severity in critically ill patients. 2,3 It has been reported in women with osteoarthritis undergoing total hip arthroplasty. 4 A high percentage of female patients with hip arthritis have been shown to be osteopenic with signs of increased bone turnover.…”
Vitamin D deficiency has been reported previously in patients with osteoarthritis undergoing total hip arthroplasty. We found a high prevalence of vitamin D deficiency in elderly patients with advanced knee osteoarthritis scheduled for total knee replacement and also a significant association with a lower preoperative functional state. A review of the literature is given on vitamin D deficiency in patients with knee osteoarthritis and the association with lower outcome scores after arthroplasty is discussed.Vitamin D is an important fat soluble vitamin that regulates calcium metabolism. The plasma 25(OH)D3 levels are highly dependent on sunlight exposure and dietary intake, and can be influenced by systemic inflammatory responses as well.
“…Evidence in support of this hypothesis came from studies that showed secondary hyperparathyroidism was linked to hypocalcemia and low 25(OH)D3 levels [23][24][25].…”
In this mini-review of hypocalcemia in the critically ill patient historical and new insights in the function of the PTH-vitamin D axis are discussed Special attention is given to the role of locally tissue produced calcitriol in the immune system and in the inflammatory cytokine response of the vitamin D deficiënt critically ill patient.Future directions in this research area and in the forthcoming research on the use of the anabolic recombinant PTH analogues in critical care medicine are discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.