Incidence, mortality and outcome of meningiomas: A population-based study from Germany

Holleczek, Bernd; Zampella, D; Urbschat, Steffi; Sahm, Felix; Deimling, Andreas von; Oertel, Joachim; Ketter, Ralf

doi:10.1016/j.canep.2019.07.001

Cited by 121 publications

(83 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We retrieved 321 cases of intracranial meningioma occurring in patients older than 65 years. We report a female predominance according to literature data [9]. When analyzing the comorbidities using the Charlson scale, we obtained a low index (1.2).…”

Section: Discussionmentioning

confidence: 94%

Intracranial Meningiomas in the Elderly: Clinical, Surgical and Economic Evaluation. A Multicentric Experience

Cannizzaro

Tropeano

Zaed

et al. 2020

Cancers

View full text Add to dashboard Cite

Meningioma is one of the most common intracranial tumors. It is benign and slow growing in the majority of cases. Given the increase in life expectancy and the number of radiological tests performed, the incidence in the elderly population (≥65 years) is continuously increasing. The surgical outcomes and prognostic factors in this age group are unclear. A retrospective analysis of all the patients treated for intracranial meningiomas in two different Italian institutions was performed. The clinical, radiological, surgical and follow-up data were retrospectively reviewed. Statistical analyses were performed to identify relationships between factors and outcomes. We also carried out an economic analysis. We analyzed 321 patients with intracranial meningioma. The mean age was 72.6 years (range, 65–90), with a female predominance (F/M, 1.41). Pre-operative deficits, cognitive impairment and seizures (p < 0.001) were associated with a worse post-operative Karnofsky performance scale (KPS) score (<80). A high pre-operative KPS score was associated with a good clinical and neurological outcome (p < 0.001). Being aged between 65 and 74 years, low surgical timing and Simpson removal grades of I and II were associated with a good outcome (p < 0.001). The length of hospitalization was significantly related to the outcome (p < 0.001). The complication rate was 14.3%. At 6-month follow-up, the mortality rate was 2.5%. The average cost was higher in patients with a pre-operative KPS score lower than 80. The outcome of intracranial-meningioma resection in elderly individuals is favorable when the pre-operative KPS score is >80. Treatment should be patient-specific, and additional factors should be considered. Patients with poor pre-operative clinical conditions might benefit from a combined strategy with partial resection and radiosurgery in order to reduce surgical timing and the complication rate.

show abstract

Section: Discussionmentioning

confidence: 94%

Intracranial Meningiomas in the Elderly: Clinical, Surgical and Economic Evaluation. A Multicentric Experience

Cannizzaro

Tropeano

Zaed

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…Approximately 80% of the cases of meningiomas described in the literature are benign and correspond to grade I according to the current WHO classification, with the meningothelial subtype being the most frequent, followed by fibroblastic and transitional, which combines the two patterns mentioned above, with transitions between both [34]. Holleczek et al [4] found in their study the proportion of 70%, 28%, and 3% of Journal of Oncology meningiomas of grades I, II, and III, respectively, according to the WHO classification. e population studied in the present study was mostly composed of grade I type and meningothelial subtype, followed by fibroblast, and these findings are similar to those found in other populations in relation to the frequency of the type of histological grade, despite the fact of being ethnically quite distinct of the population analyzed by those authors.…”

Section: Discussionmentioning

confidence: 99%

“…ey arise from meningothelial arachnoid cells and are often attached to the internal surface of the dura mater [4,5]. ey are mostly benign and slow growing, although a small proportion present malignant behavior, characterized by invasive growth patterns and/or significantly higher recurrence rates [6].…”

Section: Introductionmentioning

confidence: 99%

Meningiomas: An Overview of the Landscape of Copy Number Alterations in Samples from an Admixed Population

Silveira

Ferreira

Amorim

et al. 2020

Journal of Oncology

View full text Add to dashboard Cite

Meningiomas are considered the most common intracranial tumors, affecting mainly women. Studies in mixed populations can be of great importance to clarify issues related to the genetic diversity of tumors and their development. Considering that data obtained from analyses of the profile of copy number alterations (CNA) have been a useful diagnostic indicator for many types of tumors and that meningiomas show a complex pattern of gains and losses in the number of copies, our objective was to analyze the CNA profile in 33 samples of meningiomas of different histological grades (WHO Grade I-III) from patients in a city located in the Amazon region of Brazil, using aCGH. We found that the female to male ratio was 3 : 1. The aCGH analysis revealed a total of 2304 CNA, with an average of 69.8 ± 57.4 per case, of which 1197 were gains (52%), 926 were losses (40.2%), 105 were amplifications (4. 5%), and 76 were deletions (3.3%). A significant relationship was observed between the type of CNA and the degree of the tumor (chi-square test: χ2 = 65,844; p<0.0001; contingency coefficient: C = 0.1772; p<0.0001). Evaluating the recurrent changes in at least 50% of the samples, we observe as the most frequent losses of the segments 22q13.1-q13.2 (82%), 1p35.3 (76%), and 14q13.1-q13.2 (67%), involving all histopathological grades. The analysis of these regions showed the inclusion of genes with functions such as regulation, maintenance of cell survival, reorganization of the cytoskeleton, cell signaling, and DNA repair, among others. However, overall, the profiles observed in meningiomas of this admixed population were very similar to the ones observed in Caucasian groups. An interesting finding was a recurrent gain of 8p22 observed only in grade I meningiomas, a region which includes DLC1, a suppressor candidate gene probably implicated in the developments or progression of meningiomas, usually found deleted, when related to CNAs.

show abstract

“…Lebensjahr (Verhältnis 3:1) und bei spinalen Meningeomen deutlich wird, die zu 90 % Frauen betreffen [2]. Das mittlere Erkrankungsalter liegt bei etwa 63 Jahren [3].…”

Section: Epidemiologieunclassified

Neues zur Einteilung und Therapie von Meningeomen

Seliger¹,

Wick²

2020

Neurologie up2date

View full text Add to dashboard Cite

Incidence, mortality and outcome of meningiomas: A population-based study from Germany

Cited by 121 publications

References 43 publications

Intracranial Meningiomas in the Elderly: Clinical, Surgical and Economic Evaluation. A Multicentric Experience

Intracranial Meningiomas in the Elderly: Clinical, Surgical and Economic Evaluation. A Multicentric Experience

Meningiomas: An Overview of the Landscape of Copy Number Alterations in Samples from an Admixed Population

Neues zur Einteilung und Therapie von Meningeomen

Contact Info

Product

Resources

About