Incidence of Canine Lymphoid Leukosis Age, Sex and Breed Distribution; Results of a Necropsic Survey

Parodi, André-Laurent; Wyers, Monique; Paris, Juan

doi:10.1159/000391267

Cited by 6 publications

(4 citation statements)

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“…Lymphomas affect dogs of all ages but predominantly those in middle-age. The mean age of dogs with NHL has been reported to vary from 6.3 to 7.7 years (6,9,12,13,15). This is in agreement with our epidemiological study at the UUCCA in which the median age of the 254 dogs with NHL was 6.6 years and the age distribution was similar for both sexes.…”

Section: Descriptive Epidemiologysupporting

confidence: 90%

Canine malignant lymphoma: A review and comparison with human non‐hodgkin's lymphoma

Teske

1994

Veterinary Quarterly

144

142

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Section: Descriptive Epidemiologysupporting

confidence: 90%

Canine malignant lymphoma: A review and comparison with human non‐hodgkin's lymphoma

Teske

1994

Veterinary Quarterly

144

142

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“…The current veterinary data concern all the lymphomas without reference to the phenotype. In our study, the average age (6.9 years) of the dogs affected by a T-cell lymphoma does not show any difference with the one (from 6.3 to 7.7 years) from the previous veterinary studies 3,31,54,70,72,84 and may be compared with the human T-lymphomas data. However, a slight difference of the average age seems to appear between low-grade and high-grade lymphomas, the lymphomas affecting the youngest animals being the unclassifiable high-grade plasmacytoid and lymphoblastic lymphomas and the oldest animals being affected by the mycosis fungoides.…”

Section: Discussionsupporting

confidence: 41%

Canine T-cell Lymphomas: A Morphological, Immunological, and Clinical Study of 46 New Cases

et al. 2002

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The aim of this study is to report 46 new cases of canine T-cell lymphomas among a series of 140 lymphomas studied by immunophenotyping (incidence 32.8%). According to the updated Kiel classification adapted to the canine species, 13 were classified as low-grade and 33 as high-grade lymphomas. Among the low-grade lymphomas, five were small clear-cell lymphomas, three were pleomorphic small-cell lymphomas, and five mycosis fungoides. Among the high-grade cases, there were 11 pleomorphic mixed-, small-, and large-cell lymphomas, 6 pleomorphic large-cell lymphomas, 11 lymphoblastic lymphomas, and 5 unclassifiable high-grade plasmacytoid lymphomas. The cytohistologic features were highly suggestive of a T-cell phenotype on the basis of cell morphology (irregular nuclei and clear cytoplasms) (30/46 cases), a T-cell zone pattern, and the presence of hyperplastic postcapillary venules (22/46 cases). All 46 cases were CD3+ CD79a-, and among 34 cases investigated for CD4 and CD8 expression, 13 were CD4+CD8-, 13 were CD8+CD4-, and 8 were CD4CD8 double positive or double negative. The pleomorphic mixed lymphomas were mainly CD4+CD8- (6/7) and the lymphoblastic lymphomas were double positive or double negative (6/8). The main clinical, hematologic, and biochemical features were generalized (28/46) or regional lymphadenopathy (16/46), hepatosplenomegaly (15/46), extranodal involvement (11/46), mediastinal mass (9/46), and leukemia (8/46), which were mainly present in cases of lymphoblastic lymphomas and hypercalcemia (16/46).

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“…They usually originate from lymphoid tissues such as the lymph nodes, spleen, and bone marrow, but may arise in almost all tissues of the body [12,13]. The median ages of dogs and cats with lymphoma have been reported to be 6-9 years and 2-6 years, respectively [1,10,13]. Six years is an advanced age considering the life expectancy of rabbits.…”

mentioning

confidence: 99%

A Case of Lymphoma Developing in the Rabbit Cecum

Ishikawa

Makino

Kondo

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A rare lymphoma that developed in the cecum of a domestic pet rabbit (6 years old, male, crossbred) was examined pathologically. The tumor consisted of proliferating neoplastic lymphoid cells, which were strongly stained with anti-CD79α monoclonal antibody. Electron microscopy revealed the tumor cells were composed of rough endoplasmic reticula and/or dilated rough endoplasmic reticula filled with moderately electron-dense material. These findings indicated the present case was rare digestive tract lymphoma originated from B-lymphocytic lineage in the cecum. KEY WORDS: cecum, lymphoma, rabbit.J. Vet. Med. Sci. 69(11): 1183-1185, 2007 The domestic rabbit tumors have been known to develop in respiratory system and particularly urogenital system, and the number of reports has been increasing lately [3]. Recent studies have reported that malignant lymphoma is the second most frequently occurring tumor [12] and has a predilection for the hilar and mediastinal lymph nodes, liver, spleen, and kidney in domestic pet rabbits [2,3,12]. The prognosis for lymphoma in rabbits is poor, and no specific treatment has yet been established [8]. In this study, we pathologically examined an apparently primary lymphoma of the rabbit cecum, which has been rarely reported.A 6-year-old, male, crossbred pet rabbit of unknown weight was referred a private animal hospital in the Saitama Prefecture with a chief complaint of appetite loss and a reduction in stool volume. A physical examination revealed a molar root abscess and molar overgrowth. In spite of the treatment, it showed no sign of improvement. Further checkups including hematological examination and ultrasound revealed anemia and an abdominal mass, respectively. With owner's permission of surgery, resection of the mass was attempted. However the rabbit died of heart failure during surgery, therefore the necropsy was performed and removed major organs for histopathological examination.These tissues were routinely fixed in 10% neutral buffered formalin and embedded in paraffin. Sections were stained with hematoxylin and eosin (HE) for histological observation. Immunohistochemical staining was performed by the streptavidin-biotin-peroxidase (SAB-PO) method using mouse monoclonal anti-human CD3 antibody (DAKO), mouse monoclonal anti-human CD79α antibody (DAKO) and mouse monoclonal anti-human BLA36kD antibody (NOVOCASTRA). In addition, a part of the formalin-fixed tissue specimens were re-fixed in 1% glutaraldehyde-4% formalin, post-fixed in 1% osmium-0.1 M cacodylic acid buffer and embedded in epoxy resin. Ultrathin sections were double-stained with uranyl acetate and lead citrate, and observed under a JEM1010 transmission electron microscope (JEOL, Tokyo).On gross examination, bowl loops were prominently distended. The oval mass sized in 4.0 × 7.5 cm was presented in the end of cecum. The mass showed the blotchy hemorrhages under the serosa (Fig. 1). Its cross-section revealed a grayish-white solid tissue with a central necrosis and hemorrhage. A few mesenteric lymph nodes...

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Incidence of Canine Lymphoid Leukosis Age, Sex and Breed Distribution; Results of a Necropsic Survey

Cited by 6 publications

References 0 publications

Canine malignant lymphoma: A review and comparison with human non‐hodgkin's lymphoma

Canine malignant lymphoma: A review and comparison with human non‐hodgkin's lymphoma

Canine T-cell Lymphomas: A Morphological, Immunological, and Clinical Study of 46 New Cases

A Case of Lymphoma Developing in the Rabbit Cecum

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