Incidence of cleft lip and palate in Tehran

Jamilian, Abdolreza; Nayeri, F; Babayan, A.

doi:10.4103/0970-4388.37013

Cited by 47 publications

(61 citation statements)

References 17 publications

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“…22 There were 246 cases of cleft patients seen at out unit from 2006 to 2009; 15 of which (6.1%) had a history (6.7%) with isolated CL. Stoll 26 and Jamilian et al 25 found lower rates for CL, as was the case in our sample. Some studies have suggested that unilateral CLP (left or right) are more frequent that bilateral CLP.…”

Section: Discussionmentioning

confidence: 47%

“…Among the group of children without NSCLP, only 8% came from consanguineous marriages. 25 The relationship between congenital anomalies and consanguinity has been noted in other papers. A study on the presence of congenital anomalies in children of consanguineous marriages found a significant association between first degree consanguinity and anomalies such as cerebral palsy, cystic fibrosis, physical retardation, congenital blindness, and NSCLP.…”

Section: Discussionmentioning

confidence: 99%

“…4,24 Besides genes and environment, consanguinity has also been implicated in CLP and other congenital anomalies. 2,20,25 The risk of congenital disorders is about 2 to 3% in non-consanguineous marriages, of consanguinity. Epidemiologic and genetic studies of 207 NSCLP cases in France revealed that 3.9% of patients had a history of first degree consanguinity among parents; a positive association was found between consanguinity and NSCLP.…”

Section: Discussionmentioning

confidence: 99%

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Estudo de pacientes com fissuras lábio-palatinas com pais consanguíneos

Aquino¹,

Paranaíba²,

Martelli³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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Cl eft lip and/or palate (CL/P) are the most common congenital anomalies of the face. CL/P are non-syndromic (CL/PNS) in about 70% of subjects. Aim:To describe clinical cases of non-syndromic CL/P (CL/PNS) associated with consanguinity, diagnosed at a reference hospital in Minas Gerais, Brazil, and to correlate these alterations with possible risk factors. Series and Methods:A retrospective study at a reference hospital for craniofacial deformities in Minas Gerais, Brazil from 2006 to 2009 based on data in medical records. Results:Of 246 CL/PNS cases diagnosed and treated at the institution, 15 (6.1%) were CL/PNS with reported first-degree consanguinity; 73.3% occurred in males. Four of 15 patients had complete right cleft palate and lip (CLP), 4 presented complete cleft palate and lip (right and left), 3 had complete unilateral left CLP, 3 had isolated cleft palate, and 1 presented cleft lip only. Among the risk factors, only three mothers reported smoking during pregnancy.Conclusions: CLP (unilateral or bilateral) were more frequent in the group with a history of firstdegree consanguinity; males predominated. Among the risk factors, only smoking was observed in three cases.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Estudo de pacientes com fissuras lábio-palatinas com pais consanguíneos

Aquino¹,

Paranaíba²,

Martelli³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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“…The highest incidence rate was found in Native Americans as 3.74 per 1000, followed by Japanese subjects as 3.36 per 1000 live births. 5,6 Cleft lip occurs more common in male than female whereas cleft palate occurs more commonly in female than in male reason for this is that fusion of the palatine shelves 1 week later in girls than in boys is thought thus it could be one of factor contributing in higher frequency of cleft palate in girls. 3,7 Indian being the second most populous country of world with population of 1.21 billion, it is estimated that 24.5 million births per year and the birth prevalence of clefts is somewhere between 27,000 and 33,000 clefts per year.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, folic acid has been reported to have a protective effect. 6 India is the second most populated country in the world with a population of 1.02 billion. For its administration it is divided into 28 states and 7 union territories.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Cleft Lip and Palate in Pediatric Patients

2015

IJSR

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Prevalence of this congenital CL/P deformity is reported as 0.5-2 per 1000 live births depending on the country's population.Cleft lip and palate is more frequent in Asian countries (2.1 in 1000), as compared to African and American countries.This work was carried out at, over a period of 5 years. The study was approved by the Research and Ethics Committee of the hospital. A total number of 1800 patients including primary and secondary cleft lip and palate were investigated. The details of the subjects in terms of history, clinical features and haematological investigations were recorded on an investigator-designed proforma, after obtaining an informed consent from the patient.From a total of 2800 cases, 40 children with CL ± P were examined between the study periods. According to this incidence, the confidence interval by the probability 95% was 1.9-2.34 per 1000 live births.The age of patients ranged from 1 day to 15 years. Majority of the cases were females. It as been found that CLP were more common representing followed by CL, CP and rare cleft in both sexes.

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Consanguinity and occurrence of cleft lip/palate: A hospital‐based registry study in Riyadh

Ravichandran

Shoukri

Aljohar

et al. 2012

American J of Med Genetics Pt A

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This paper focuses on the influence of consanguinity on the occurrence of orofacial clefts. All patients with orofacial clefts registered at King Faisal Specialist Hospital and Research Center, Riyadh since June 1999 until December 2009 were included in this study. Patients were classified in two distinct groups: cleft lip with or without cleft palate (CL ± P) and isolated cleft palate (CP). Chi-squared test was used to test independence of variables. Intracluster correlation coefficient was estimated to assess the degree of concordance between siblings. Among 1,171 total patients, CL ± P was found to be more common (64.0%). Males were more likely to be affected with CL ± P (M:F = 1.5:1) and females were more likely to be affected with CP (M:F = 0.9:1; P < 0.0001). About a third of patients had a family history of clefts; family history was more likely to be positive for patients with CL ± P than for patients with CP (33.6% vs. 22.0%; P < 0.0001). Consanguineous relationships were seen in 56.8% of our patients' parents. Family history was more likely to be positive for patients whose parents were consanguineous than those who were non-consanguineous (34.2% vs. 25.8%; P = 0.003), both for the CL ± P and CP groups. Recurrence among siblings did not differ between those born to consanguineous versus non-consanguineous parents. Recurrence of clefts in offspring was higher among parents affected by cleft compared to those who were not affected (51.4% vs. 11.4%; P < 0.0001), both for CL ± P and CP groups. Education about anticipated genetic consequences of consanguinity is important for populations with a high degree of consanguinity.

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Incidence of cleft lip and palate in Tehran

Cited by 47 publications

References 17 publications

Estudo de pacientes com fissuras lábio-palatinas com pais consanguíneos

Estudo de pacientes com fissuras lábio-palatinas com pais consanguíneos

Epidemiology of Cleft Lip and Palate in Pediatric Patients

Consanguinity and occurrence of cleft lip/palate: A hospital‐based registry study in Riyadh

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